Evaluation of environmental effects of heavy metals on biochemical profile and oxidative stress among children at brick kiln sites

David, Mehwish; Turi, Naheed; Ain, Qurat Ul; Rahman, Humaira; Jahan, Sarwat

doi:10.1080/19338244.2020.1854645

Cited by 6 publications

(7 citation statements)

References 35 publications

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“…39 A more recent study detected an altered antioxidant enzymes status, increased cortisol level, and cellular DNA damage in young subjects living at brick kiln sites in Pakistan. 40 In the current study, a significant positive association between OS and oxidative stress was observed through the statistical correlation analysis (Table 2) and was confirmed by the multiple linear regression analyses in Tables 3, 4, and 5. The OSI scores were significantly and positively correlated with the urinary levels of both oxidative stress biomarkers (8-OHdG and biopyrrins) in the studied brickfield workers.…”

Section: Discussionsupporting

confidence: 78%

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Studying the Association Between Occupational Stress and Urinary Levels of Oxidative Stress Biomarkers (8-OHdG and Biopyrrins) in Brickfield Workers

Mourad

2022

J Occup Environ Med

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Objectives: The aims of the study are to measure the prevalence and level of occupational stress (OS) and to explore its association with oxidative stress among some brickfield workers. Methods: Eighty-six brickfield workers and 90 administrative controls were assessed using the Arabic validated version of the Occupational Stress Index. The urinary levels of oxidative biomarkers; 8hydroxy-2′-deoxyguanosine and biopyrrins were also measured. Results: The prevalence of moderate and severe OS in addition to the urinary levels of both oxidative biomarkers was significantly higher among the brickfield workers compared with their controls. Both biomarkers levels were significantly and positively correlated with scores of Occupational Stress Index, duration of employment, and with each other. The receiver operating characteristic analysis showed significant specificity and sensitivity of both biomarkers for determining the level of OS. Conclusions: A significant association between occupational and oxidative stresses was detected in brickfield workers.

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Section: Discussionsupporting

confidence: 78%

“…A significant oxidative stress status was also observed by another study conducted in a brickmaker’s community in Mexico 39 . A more recent study detected an altered antioxidant enzymes status, increased cortisol level, and cellular DNA damage in young subjects living at brick kiln sites in Pakistan 40 …”

Section: Discussionsupporting

confidence: 55%

Studying the Association Between Occupational Stress and Urinary Levels of Oxidative Stress Biomarkers (8-OHdG and Biopyrrins) in Brickfield Workers

Mourad

2022

J Occup Environ Med

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“…Based on the current findings, it is evident that brick kiln workers are at the verge for developing public and reproductive health concerns. It is recommended that there must be recurrent inspection of the monitoring strategies for brick kiln emissions as well as regular medical checks of workers to ensure an improved quality of life among laborers 20 , 45 . Governmental bodies should also monitor issues related to bonded labor and social risks associated with the brick kiln industry 3 .…”

Section: Discussionmentioning

confidence: 99%

“…Serum samples were analyzed for antioxidant enzyme activity of SOD (units/mg of protein), POD, and lipid peroxidation via Malondialdehyde (MDA) on a UV Spectrophotometer (Agilent 8453), while oxidant concentrations of reactive oxygen species (ROS) was determined using previously established methods 42 – 45 . The systems were calibrated with standards and comparison with reported literature was made.…”

Section: Methodsmentioning

confidence: 99%

Biochemical and reproductive biomarker analysis to study the consequences of heavy metal burden on health profile of male brick kiln workers

David

Jahan

Hussain

et al. 2022

Sci Rep

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The present study aims to assess the effect of a heavy metal burden on general health, biochemical parameters, an antioxidant enzyme, and reproductive hormone parameters in adult male brick kiln workers from Pakistan. The study participants (n = 546) provided demographic data including general health as well as body mass index. Blood was collected to quantitatively assess hematological, biochemical, and reproductive hormone parameters as well as heavy metal concentrations using both atomic absorption spectroscopy (AAS) and particle-induced X-ray emission (PIXE). The data showed that 10% of the brick kiln workers were underweight and 10% obese (P = 0.059), with workers also reporting multiple health issues. Heavy metal concentrations utilizing AAS revealed significantly (p = 0.000) higher levels of cadmium, chromium, and nickel, while PIXE detected more than permissible levels of Si, P, S, Cl, K, Ca, Zn, Ti (p = 0.052), Mn (p = 0.017), Fe (p = 0.055), Co (p = 0.011), Ni (p = 0.045), and Cu (p = 0.003), in the blood of kiln workers. Moreover, a significant increase in platelet count (P = 0.010), a decrease in sodium dismutase levels (p = 0.006), a major increase in reactive oxygen species (p = 0.001), and a reduction in protein content (p = 0.013) were evident. A significant increase in cortisol levels (p = 0.000) among the workers group was also observed. The concentration of LH and FSH increased significantly (p = 0.000), while that of testosterone decreased (p = 0.000) in the worker group compared with controls. A significant inverse relationship was found between cortisol, LH (r = − 0.380), and FSH (r = − 0.946), while a positive correlation between cortisol and testosterone was also evident (r = 0.164). The study concludes that increased heavy metal burden in the blood of brick kiln workers exposes them to the development of general and reproductive health problems due to compromised antioxidant enzyme levels, increased oxidative stress conditions, and a disturbing reproductive axis.

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“…The results showed a significant decrease in most hematological indices (RBCs count, Hb content, Hct%, MCV, MCH, MCHC, and WBCs count), especially at 100%.EF group compared to control. David et al ( 2020 ) attributed this decrease to the generated ROS from metals that disrupt hematopoiesis in the bone marrow.…”

Section: Discussionmentioning

confidence: 99%

Ecotoxicological impacts of industrial effluents on irrigation water quality, animal health and the role of calcium alginate in effluents treatment

Zeid

El-Zayat

Abdrabouh

2022

Environ Monit Assess

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The effluents discharged from Mansoura Company for Resins and Chemicals Industry were evaluated for drinking and irrigation purposes. Calcium-alginate beads were used for effluents treatment in this study. Young male rats were also allowed to drink effluents at different concentrations (10%, 50%, 100%) and treated 100% effluents with calcium-alginate for 11 weeks. Results indicated high concentrations of some physicochemical parameters and Cd, Co, Fe, Mn, Ni, Pb, and Zn in effluents that exceeded the permissible limits for drinking and irrigation purposes. Treatment by calcium-alginate alleviate heavy metals concentration but did not affect the physicochemical parameters. Depending on effluents concentration, the liver of young male rats showed high accumulation of Fe, Mn, Zn, Pb, Cd, Co, Cu, Cr, and Ni compared to the control group. Serum levels of liver enzymes, total bilirubin significantly increased while total protein, and albumin contents decreased in effluent groups. Liver concentrations of malondialdehyde and protein carbonyl significantly elevated along with significant decrease in superoxide dismutase, catalase, glutathione-S-transferase activities, and glutathione content. Moreover, growth and thyroid hormones were significantly reduced along with significant elevation in thyroid stimulating hormone. This was accompanied by significant decrease in the body weight, especially with 100% effluents concentration compared to control group. Also, histological investigations of both liver and thyroid gland using hematoxylin and eosin showed distortion in the structure of both organs especially with 50% and 100% effluent groups. However, treatment of effluents by calcium-alginate improved these changes. The study revealed that calcium-alginate are effective biosorbents for heavy metals and consequently decrease animal and human health hazards, but further studies are needed to alleviate physicochemical characteristics.

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Evaluation of environmental effects of heavy metals on biochemical profile and oxidative stress among children at brick kiln sites

Cited by 6 publications

References 35 publications

Studying the Association Between Occupational Stress and Urinary Levels of Oxidative Stress Biomarkers (8-OHdG and Biopyrrins) in Brickfield Workers

Studying the Association Between Occupational Stress and Urinary Levels of Oxidative Stress Biomarkers (8-OHdG and Biopyrrins) in Brickfield Workers

Biochemical and reproductive biomarker analysis to study the consequences of heavy metal burden on health profile of male brick kiln workers

Ecotoxicological impacts of industrial effluents on irrigation water quality, animal health and the role of calcium alginate in effluents treatment

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