Evaluation of endothelial dysfunction, lipid metabolism in women with polycystic ovary syndrome: relationship of paraoxonase 1 activity, malondialdehyde levels, low-density lipoprotein subfractions, and endothelial dysfunction

Bayram, Fahri; Koçer, Derya; Özsan, Müge; Muhtaroğlu, Sabahattin

doi:10.3109/09513590.2011.569607

Cited by 28 publications

(21 citation statements)

References 27 publications

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“…We found a significant reduction in circulating level of NO end product (NOx) in PCOS women compared to controls. Previous studies have reported reduction in NO in Turkish population [27] while Gao et al [34] showed increased levels of NO in non-obese Chinese PCOS women. Meanwhile a couple of other studies reported no significant difference in NO levels among PCOS patients and controls [35, 36].…”

Section: Discussionmentioning

confidence: 99%

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Impaired Arginine Metabolism Coupled to a Defective Redox Conduit Contributes to Low Plasma Nitric Oxide in Polycystic Ovary Syndrome

Krishna

Joseph

Thomas

et al. 2017

Cell Physiol Biochem

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Background: Though oxidative stress is associated with Polycystic Ovary Syndrome (PCOS), the status of nitric oxide is still unclear. Nitric Oxide (NO) plays pivotal roles in many physiological functions which are compromised in PCOS. Our recent study reveals lowered T-regulatory cells (Tregs) in PCOS, and Treg generation is known to be regulated by NO levels. However concrete evidences are lacking on mechanisms modulating NO levels under PCOS. Methods: This is a retrospective case-control cohort study, comprised of PCOS women (N=29) and normal menstruating women as controls (N=20). We analysed NOx (nitrite+nitrate) and hydrogen peroxide (H₂O₂) concentrations, transcript levels of endothelial nitric oxide synthase (eNOS)/inducible nitric oxide synthase (iNOS) and arginine modulators, hydrogen peroxide regulators in the cohort. Results: PCOS women showed reduced plasma NOx(nitrate+nitrite) and H₂O₂ compared to controls. We report reduction in transcript levels of iNOS/NOS2 and eNOS/NOS3 in PCOS peripheral blood. The transcripts involved in arginine bioavailability: Argininosuccinate lyase (ASL), Solute Carrier Family1, member 7 (SLC7A1) and Arginase 1 (ARG1) and Asymmetric Dimethyl Arginine (ADMA) metabolism: Protein arginine methyltransferase 1 (PRMT1) and Dimethylarginine dimethylaminohydrolase 2 (DDAH2) also showed differential expression. H₂O₂ concentration in PCOS women was also found to be reduced. The reduction can be attributed to increase in catalase levels as a consequence of the body’s effort to alleviate the oxidative burden in the system. Conclusion: Our study advocates that PCOS women have lowered NO due to reduced iNOS/eNOS expression, low H₂O₂, high ADMA synthesis and reduced arginine bioavailability. An in-depth analysis of redox biology of PCOS to open up potential therapeutic strategies is highly recommended.

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Section: Discussionmentioning

confidence: 99%

“…Contradictory reports exist about the status of NOx under PCOS. Some researchers reported decreased NO metabolites in PCOS [27, 28]. Another noteworthy study performed in PCOS women has proved that the pregnancy rate in PCOS women can be increased through NO administration [29].…”

Section: Introductionmentioning

confidence: 99%

Impaired Arginine Metabolism Coupled to a Defective Redox Conduit Contributes to Low Plasma Nitric Oxide in Polycystic Ovary Syndrome

Krishna

Joseph

Thomas

et al. 2017

Cell Physiol Biochem

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“…According to some researches, there is a direct relation between increased malondialdehyde (MDA) and decreased antioxidant (PON1) activity and total antioxidant capacity (TAC). Since PON1 activity is lower in the PCOS women, dyslipidemia is common in these women; it may cause lower-density-lipoprotein ( LDL) oxidation in arterial walls, so atherogenesis is also common in the PCOS women (24,25). Many studies about the effects of vitamin D and its derivatives on the hyperandrogenism, menstrual irregularity, infertility, insulin resistance (IR), and oxidative stress showed the therapeutic and protective effect of vitamin D3 ,25 hydroxy vitamin D, and also calcium in the PCOS women (26)(27)(28).…”

Section: Discussionmentioning

confidence: 99%

Ultra-structural Study by Transmission Electron Microscopy: Effect of Omega-3 on Ovary Cell Organelles after Experimental Induced Poly Cystic Ovary Syndrome

Ouladsahebmadarek¹,

Khaki²

2014

IJWHR

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Objectives: Polycystic ovary syndrome (PCOS) is the most frequent cause of female infertility, affecting about 4% to 8% of women in the age of procreation. For evaluation the protective effects of omega-3 polyunsaturated fatty acid on ovarian structure in experimental PCO induced by estradiol-valerat, this research was done. Materials and Methods: Wistar female rats (n=40) were allocated into four groups, one control (n=10) and three test groups (n=30), that one group received omega-3 (60 mg/rat/orally/daily), second and third groups were induced PCO by single injection of estradiol-valerate (16mg/ kg/ i.m), third group also received omega-3 (240 mg/kg) for 60 consequence days. Animals were kept in standard conditions. On day 60, the ovarian tissue of Rats in whole groups were removed and prepared for pathological analysis. Results: vacuolated area and rough endoplasmic reticulum expanded, de-granulated, disorganized were seen in PCO groups; however, these side effects decreased in the groups that received omega-3 significantly (p<0.05) in comparison to experiment groups and ovarian weights in PCO experimental decreased significantly (p<0.05). Conclusion: Results revealed that administration of omega-3 could significantly treat PCO. This suggested that polyunsaturated fatty acid could diminish negative side effects of PCO on ovary tissue.

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“…Although NO plays a major role in the pathophysiology of PCOS [67], the concentration of NO remains controversial in PCOS women when compared to that of the control. Nitric oxide levels have been reported to likely increase [21], decrease [68,69] and remain unchanged [48,70,71] between PCOS and control women. In support of the fact that PCOS women have less NO levels, Taslipinar et al reported that ADMA levels are significantly higher in PCOS women than in the controls [69].…”

Section: Nitric Oxide Bioavailability In Pcosmentioning

confidence: 99%

Oxidative stress and cardiovascular complications in polycystic ovarian syndrome

Hyderali¹,

Kundabala²

2015

European Journal of Obstetrics & Gynecology and Reproductiv

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Evaluation of endothelial dysfunction, lipid metabolism in women with polycystic ovary syndrome: relationship of paraoxonase 1 activity, malondialdehyde levels, low-density lipoprotein subfractions, and endothelial dysfunction

Cited by 28 publications

References 27 publications

Impaired Arginine Metabolism Coupled to a Defective Redox Conduit Contributes to Low Plasma Nitric Oxide in Polycystic Ovary Syndrome

Impaired Arginine Metabolism Coupled to a Defective Redox Conduit Contributes to Low Plasma Nitric Oxide in Polycystic Ovary Syndrome

Ultra-structural Study by Transmission Electron Microscopy: Effect of Omega-3 on Ovary Cell Organelles after Experimental Induced Poly Cystic Ovary Syndrome

Oxidative stress and cardiovascular complications in polycystic ovarian syndrome

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