Evaluation of endothelial dysfunction in patients with familial Mediterranean fever: the relationship between the levels of asymmetric dimethylarginine and endocan with carotid intima–media thickness and endothelium-dependent vasodilation

Özalper, Veysel; Kara, Muammer; Tanoğlu, Alpaslan; Çetindağlı, İbrahim; Öztürker, Coşkun; Hancerlı, Yusuf; Hira, Serdar; Kara, Kemal; Beyazıt, Yavuz; Yazgan, Yusuf

doi:10.1007/s10067-016-3532-2

Cited by 23 publications

(18 citation statements)

References 27 publications

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“…20 , TurkeyASsELISA64030.035/50.53 ± 0.166032.253/70.75 ± 0.19Ozalper et al . 57 , TurkeyFMFsELISA63524.735/01.43 ± 0.49 § 5724.357/01.48 ± 1.06 § Radhakutty et al . 44 , AustraliaRApLC-MS82063.04/160.48 ± 0.013665.012/240.55 ± 0.03NOS: Newcastle–Ottawa quality assessment scale for case-control studies (number represent stars).…”

Section: Resultsmentioning

confidence: 99%

“…After a full-text review of 81 articles, 44 were rejected because they did not meet the inclusion criteria. Thus, 37 studies were included in the meta-analysis 13–17,19–34,37,44–57 . The characteristics of these studies, published between 2006 and 2018, are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…However, the results of studies reporting the association between ADMA and RDs have been contradictory: although most studies demonstrated a significant association between ADMA and RDs 13,14,16,17,19–24,26,28,29,31–34,44–50,52–56,63 , other studies failed to report a significant relationship 15,18,25,27,30,37,57 . The different results might be at least partially explained by the small sample size of each study.…”

Section: Discussionmentioning

confidence: 99%

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Meta-Analysis of Asymmetric Dimethylarginine Concentrations in Rheumatic Diseases

Erre

Mangoni

Castagna

et al. 2019

Sci Rep

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Raised circulating concentrations of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), have been reported in several rheumatic diseases (RDs). However, the strength of this relationship is unclear. Therefore, the aim of this systematic review and meta-analysis was to evaluate the magnitude and the robustness of the association between ADMA concentrations and RDs. We calculated standardized mean differences (SMD, with 95% confidence intervals, CI). Study heterogeneity was evaluated by meta-regressions and sensitivity analyses according to type of RDs, conventional cardiovascular risk factors, inflammatory markers, and type of ADMA assessment methodology. Thirty-seven studies with a total of 2,982 subjects (1,860 RDs patients and 1,122 healthy controls) were included in our meta-analysis. Pooled results showed that ADMA concentrations were significantly higher in patients with RDs than in healthy controls (SMD = 1.27 µmol/L, 95% CI 0.94–1.60 µmol/L; p < 0.001). However, the between-studies heterogeneity was high. Differences in ADMA concentrations between controls and RDs patients were not significantly associated with inflammatory markers, increasing age, lipid concentrations, body mass index, blood pressure, or methodology used to assess ADMA. Furthermore, subgroup analysis showed no difference across RDs. This meta-analysis showed that, in the context of significant between-study heterogeneity, circulating concentrations of ADMA are positively related to RDs.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Meta-Analysis of Asymmetric Dimethylarginine Concentrations in Rheumatic Diseases

Erre

Mangoni

Castagna

et al. 2019

Sci Rep

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“…It is an indicator of endothelial cell dysfunction, activation, and angiogenesis [20-22]. Its secretion is strongly increased by inflammatory cytokines, such as TNF-α, and proangiogenic growth factors, such as VEGF and FGF-2 [8].…”

Section: Discussionmentioning

confidence: 99%

Higher Serum Endocan Level Is Associated with Alzheimer Disease

Varan

Guner

Sümer

et al. 2017

Dement Geriatr Cogn Disord

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Background: The novel molecule endocan, which is released by endothelium and is regulated by proangiogenic and proinflammatory cytokines, may have a role in the pathophysiology of Alzheimer disease (AD). The aim of this study was to evaluate the relationship between serum endocan levels and AD. Methods: A total of 134 patients (47 AD, 42 amnestic mild cognitive impairment [aMCI], and 45 control patients) 65 years of age and older were recruited in this study. Cognitive status of the patients was evaluated by performing the Montreal Cognitive Assessment (MOCA) and the Mini-Mental State Examination (MMSE). Serum endocan levels were measured with an enzyme-linked immunosorbent assay kit. Results: Median serum endocan level was significantly higher in AD patients (380.1 ng/mL) than in both aMCI patients (247.7 ng/mL) and controls (277.6 ng/mL; p < 0.01). Serum endocan level had a weak but significant correlation with MMSE and MOCA scores (r = –0.219 and r = –0.232; p = 0.012 and p = 0.01, respectively). Serum endocan level was detected as a factor independently associated with AD. The cutoff serum level of endocan predicting AD was >288.94 ng/mL in receiver operating characteristic curve analysis (area under the curve 0.71, 95% CI 66.7–90.9, sensitivity 80.9%, specificity 59.8%; p < 0.01). Conclusion: Higher serum endocan levels may be associated with the pathogenesis of AD.

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“…Carotid intima media thickness (CIMT) is a marker of subclinical atherosclerosis and regarded as predictor of vascular diseases [39]. While one study described an inverse relation of ADMA with CIMT [40], there are meanwhile numerous studies proving a positive correlation between circulating ADMA and/or SDMA concentrations with CIMT in patients with diverse demographics and different underlying diseases [41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56], however, with ethnical differences [57]. In a long-term follow-up study over six years, Furuki et al [47] showed that ADMA was an independent predictor of CIMT progression.…”

Section: The Relation Of Adma and Sdma To Atherosclerotic Diseasementioning

confidence: 99%

Arginine Derivatives in Cerebrovascular Diseases: Mechanisms and Clinical Implications

Große

Schwedhelm

Worthmann

et al. 2020

IJMS

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The amino acid L-arginine serves as substrate for the nitric oxide synthase which is crucial in vascular function and disease. Derivatives of arginine, such as asymmetric (ADMA) and symmetric dimethylarginine (SDMA), are regarded as markers of endothelial dysfunction and have been implicated in vascular disorders. While there is a variety of studies consolidating ADMA as biomarker of cerebrovascular risk, morbidity and mortality, SDMA is currently emerging as an interesting metabolite with distinct characteristics in ischemic stroke. In contrast to dimethylarginines, homoarginine is inversely associated with adverse events and mortality in cerebrovascular diseases and might constitute a modifiable protective risk factor. This review aims to provide an overview of the current evidence for the pathophysiological role of arginine derivatives in cerebrovascular ischemic diseases. We discuss the complex mechanisms of arginine metabolism in health and disease and its potential clinical implications in diverse aspects of ischemic stroke.

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Evaluation of endothelial dysfunction in patients with familial Mediterranean fever: the relationship between the levels of asymmetric dimethylarginine and endocan with carotid intima–media thickness and endothelium-dependent vasodilation

Cited by 23 publications

References 27 publications

Meta-Analysis of Asymmetric Dimethylarginine Concentrations in Rheumatic Diseases

Meta-Analysis of Asymmetric Dimethylarginine Concentrations in Rheumatic Diseases

Higher Serum Endocan Level Is Associated with Alzheimer Disease

Arginine Derivatives in Cerebrovascular Diseases: Mechanisms and Clinical Implications

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