Evaluation of endoscopic-ultrasound-guided celiac ganglion irradiation with iodine-125 seeds: a pilot study in a porcine model

Abstract

EUS-guided implantation of (125)I seeds beside the celiac ganglia is a safe procedure and can induce apoptosis of local neurons. This new method may lead to an alternative treatment for pain accompanying pancreatic diseases in human.

EUS-guided celiac ganglion irradiation with iodine-125 seeds for pain control in pancreatic carcinoma: a prospective pilot study

“…First, 125 I seeds may inflict significant damage to celiac ganglia, as demonstrated by our previous study. 11 Second, in PC patients whose celiac ganglia are invaded, 28 brachytherapy may induce apoptosis and necrosis of tumor cells, relieving the compression of celiac ganglia. Finally, concomitant use of chemotherapy may also improve pain control and enhance the effects of a celiac block.…”

“…9,10 In a previous preliminary study, we found that EUS-guided implantation of iodine-125 ( 125 I) around the celiac ganglia is a safe procedure and can induce apoptosis of local neurons in a porcine model. 11 We therefore hypothesize that direct implantation of 125 I seeds into the celiac ganglia may offer enhanced pain relief safely. To test this hypothesis, we conducted a pilot study to determine the feasibility and safety of EUS-guided direct celiac ganglion irradiation with 125 I seeds in 23 patients with moderate to severe pain secondary to unresectable PC.…”

Endoscope-assisted brachytherapy for pancreatic cancer: From tumor killing to pain relief and drainage

“…[20][21][22] EUS-guided brachytherapy with the implantation of iodine-125 seeds beside the celiac ganglion seems to be another choice for the pain relief. Recently, Wang et al 23 performed a pilot trial in a porcine model. Four pigs in each group were implanted with one 0.4 mCi or 0.8 mCi iodine-125 seed in either side of the celiac ganglion area with the help of EUS (Fig.…”

Role of endoscopic ultrasound in treatment of pancreatic cancer

“…Wang et al 46. recently evaluated the feasibility and safety of EUS-guided radiation of the celiac ganglia with 125 I seeds in a porcine model.…”