Evaluation of empiric antibiotic use in surgical sepsis

Análise da ocorrência e dos fatores predisponentes de infecção de sítio cirúrgico em pacientes sumetidos a cirurgias ortopédicas

“…A erradicação de infecção, provocada por formação de biofilmes, somente é possível quando implementada a antibioticoterapia precocemente e se for usado a concentração adequada e suficiente do antibiótico para tratar a infecção (FITOUSIS et al, 2010;MAGALHÃES, 2011 CVE, 2012;GREENE et al, 2012).…”

Compliance with an empirical antimicrobial protocol improves the outcome of complicated intra-abdominal infections: a prospective observational study

“…Most studies of intraabdominal infections have shown that appropriate empirical antibiotic therapy improved the clinical success rate and reduced the length of hospital stay and overall costs. 10 11 However, when empirical antibiotic therapy is inappropriate, patients may require reoperation, resulting in a poorer outcome [12][13][14][15][16][17] and an increased likelihood of multidrug-resistant bacteria (MDRB) such as Pseudomonas aeruginosa and yeasts. 14 18 Education and stewardship of rational antibiotic use in France, have become a major public health challenge for the World Health Organization (WHO) and the European Community over recent yr.…”

Sepsis Severa Y Cirugía

“…Se sugiere el uso de un esquema asociado que sea sinérgico y que cubra el mayor espectro posible, dada la posible fuente de infección y considerando además condiciones comórbidas del paciente y uso reciente de antimicrobianos. Existe evidencia de que la inapropiada selección de antimicrobianos se asocia a una mayor morbilidad y mortalidad 16,19 .…”