Evaluation of electrospun PCL/gelatin nanofibrous scaffold for wound healing and layered dermal reconstitution☆

Chong, Eleanor Jia Xin; Phan, Toan Thang; Lim, Ivor J.; Zhang, Yanzhong; Bay, Boon‐Huat; Ramakrishna, Seeram; Lim, Chwee Teck

doi:10.1016/j.actbio.2007.01.002

Cited by 801 publications

(526 citation statements)

References 15 publications

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“…Currently, extensive efforts are being made to develop protein-based biomaterials for biomedical applications [1,2]. Having similar macromolecular structures to naturally occurring proteins in tissues and organs, protein-based biomaterials have the potential to provide biological functionality and can be degraded by natural enzymes and metabolized by physiological mechanisms [3].…”

Section: Introductionmentioning

confidence: 99%

Cytocompatible cross-linking of electrospun zein fibers for the development of water-stable tissue engineering scaffolds

2010

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Section: Introductionmentioning

confidence: 99%

Cytocompatible cross-linking of electrospun zein fibers for the development of water-stable tissue engineering scaffolds

2010

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“…The thickness of a membrane was measured with a micrometer. The apparent density and porosity of the membrane were calculated by using equations (1) and (2), respectively [27]:…”

Section: Characterization Of Pgh-mna Nanofiber Membranes 231 Morphmentioning

confidence: 99%

Drug loaded homogeneous electrospun PCL/gelatin hybrid nanofiber structures for anti-infective tissue regeneration membranes

Xue

Liu³

et al. 2014

Biomaterials

322

219

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Email address: sharell@126.com (R. Shi). AbstractInfection is the major reason for guided tissue regeneration/guided bone regeneration (GTR/GBR) membrane failure in clinical application. In this work, we developed GTR/GBR membranes with localized drug delivery function to prevent infection by electrospinning of poly(ε-caprolactone) (PCL) and gelatin blended with metronidazole (MNA). Acetic acid (HAc) was introduced to improve the miscibility of PCL and gelatin to fabricate homogeneous hybrid nanofiber membranes. The effects of the addition of HAc and the MNA content (0,1,5,10,20,30, and 40 wt.% of polymer) on the properties of the membranes were investigated. The membranes showed good mechanical properties, appropriate biodegradation rate and barrier function. The controlled and sustained release of MNA from the membranes significantly prevented the colonization of anaerobic bacteria. Cells could adhere to and proliferate on the membranes without cytotoxicity until the MNA content reached 30%.Subcutaneous implantation in rabbits for 8 months demonstrated that MNA-loaded membranes evoked a less severe inflammatory response depending on the dose of MNA than bare membranes. The biodegradation time of the membranes was appropriate for tissue regeneration. These results indicated the potential for using MNA-loaded PCL/gelatin electrospun membranes as anti-infective GTR/GBR membranes to optimize clinical application of GTR/GBR strategies.

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“…Electrospun gelatin scaffolds have been used for various applications such as wound healing [59,60], nerve [52,61,62], dental [49], bone [48,50,57,63], dermal tissue engineering applications [64,65] and vascular grafts [66]. Much of the work published on electrospun gelatin scaffolds has been directed towards its use in cardiac tissue engineering applications.…”

Section: Gelatinmentioning

confidence: 99%

The Use of Natural Polymers in Tissue Engineering: A Focus on Electrospun Extracellular Matrix Analogues

et al. 2010

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Natural polymers such as collagens, elastin, and fibrinogen make up much of the body's native extracellular matrix (ECM). This ECM provides structure and mechanical integrity to tissues, as well as communicating with the cellular components it supports to help facilitate and regulate daily cellular processes and wound healing. An ideal tissue engineering scaffold would not only replicate the structure of this ECM, but would also replicate the many functions that the ECM performs. In the past decade, the process of electrospinning has proven effective in creating non-woven ECM analogue scaffolds of micro to nanoscale diameter fibers from an array of synthetic and natural polymers. The ability of this fabrication technique to utilize the aforementioned natural polymers to create tissue engineering scaffolds has yielded promising results, both in vitro and in vivo, due in part to the enhanced bioactivity afforded by materials normally found within the human body. This review will present the process of electrospinning and describe the use of natural polymers in the creation of bioactive ECM analogues in tissue engineering.

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Evaluation of electrospun PCL/gelatin nanofibrous scaffold for wound healing and layered dermal reconstitution☆

Cited by 801 publications

References 15 publications

Cytocompatible cross-linking of electrospun zein fibers for the development of water-stable tissue engineering scaffolds

Cytocompatible cross-linking of electrospun zein fibers for the development of water-stable tissue engineering scaffolds

Drug loaded homogeneous electrospun PCL/gelatin hybrid nanofiber structures for anti-infective tissue regeneration membranes

The Use of Natural Polymers in Tissue Engineering: A Focus on Electrospun Extracellular Matrix Analogues

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