Evaluation of Electrophysiological Effects of Melatonin and Alpha Lipoic Acid in Rats with Streptozotocine Induced Diabetic Neuropathy

Seyit, D A; Değirmenci, Eylem; Oğuzhanoğlu, Attila

doi:10.1055/s-0042-103750

Cited by 12 publications

(9 citation statements)

References 26 publications

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“…As mentioned previously, high glucose induces oxidative stress and increases Ca 2+ ion entry playing important roles in the pathogenesis of diabetic neuropathy [152]. Treatment with melatonin improves hippocampal injury and peripheral neuropathic pain in STZ-induced diabetic rats; these protective activities of melatonin are characterized by the improvement in the spatial navigation memory and results from electrophysiological studies including tibial motor nerve conduction and cortical tibial nerve somatosensory evoked potentials [153][154][155]. Melatonin inhibits oxidative stress-induced Ca 2+ mobilization through transient receptor potential (TRP) melastatin 2 (TRPM2) and TRP vanilloid type 1 (TRPV1) channels resulting in the prevention of mitochondrial depolarization, intracellular ROS production and apoptosis in neurons [153].…”

Section: Therapeutic Potentials Of Melatonin For Diabetic Neuropathymentioning

confidence: 89%

Melatonin: new insights on its therapeutic properties in diabetic complications

Pourhanifeh

Hosseinzadeh

Dehdashtian

et al. 2020

Diabetol Metab Syndr

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Diabetes and diabetic complications are considered as leading causes of both morbidity and mortality in the world. Unfortunately, routine medical treatments used for affected patients possess undesirable side effects, including kidney and liver damages as well as gastrointestinal adverse reactions. Therefore, exploring the novel therapeutic strategies for diabetic patients is a crucial issue. It has been recently shown that melatonin, as main product of the pineal gland, despite its various pharmacological features including anticancer, anti-aging, antioxidant and antiinflammatory effects, exerts anti-diabetic properties through regulating various cellular mechanisms. The aim of the present review is to describe potential roles of melatonin in the treatment of diabetes and its complications.

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Section: Therapeutic Potentials Of Melatonin For Diabetic Neuropathymentioning

confidence: 89%

Melatonin: new insights on its therapeutic properties in diabetic complications

Pourhanifeh

Hosseinzadeh

Dehdashtian

et al. 2020

Diabetol Metab Syndr

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“…Evidence related to changes in nerve conduction velocity after thioctic acid administration was observed primarily in experimental models [ 58 – 60 ].…”

Section: Discussionmentioning

confidence: 99%

R(+)‐Thioctic Acid Effects on Oxidative Stress and Peripheral Neuropathy in Type II Diabetic Patients: Preliminary Results by Electron Paramagnetic Resonance and Electroneurography

Mrakic‐Sposta

Vezzoli

Maderna

et al. 2018

Oxidative Medicine and Cellular Longevity

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Objectives Diabetic neuropathy is the most common complication of diabetes. The idea of alterations in energy metabolism in diabetes is emerging. The biogenic antioxidant R(+)-thioctic acid has been successfully used in the treatment of diabetic polyneuropathic (DPN) patients. Methods The effects of R(+)-thioctic acid (1 tablet, 1.6 g) administration were evaluated in 12 DPN patients at baseline and at 15, 30, 60, and 120 administration days throughout the assessment of oxidative stress (OxS); ROS production rate by electron paramagnetic resonance (EPR) technique; and oxidative damage biomarkers (thiobarbituric acid reactive substances (TBARS) and protein carbonyls (PC)), electroneurography (ENG) and visual analogue scale. Results Supplementation induced significant changes (p < 0.05) at 30 and 60 days. ROS production rate up to −16%; TBARS (−31%), PC (−38%), and TAC up to +48%. Motor nerve conduction velocity in SPE and ulnar nerves (+22% and +16%) and sensor conduction velocity in sural and median nerves (+22% and +5%). Patients reported a general wellness sensation improvement (+35%) at 30 days: lower limb pain sensation (−40%) and upper limbs (−23%). Conclusion The results strongly indicate that an increased antioxidant capacity plays an important role in OxS, nerve conduction velocity, pain, and general wellness improvement. Nevertheless, the effects of the antioxidant compound were found positive up to 60 days. Then, a hormesis effect was observed. Novelty of the research would be a challenge for investigators to carefully address issues, including dose range factors, appropriate administration time, and targeting population to counteract possible “boomerang effects.” The great number of monitored parameters would firmly stress these conclusions.

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“…In fact, melatonin has been shown to have substantial analgesic effects [ 17 , 18 , 19 ], and its pain modulatory properties are generally recognised e.g., [ 20 , 21 , 22 , 23 ]. Nevertheless, the involvement of melatonin in neuropathic pain regulation is not fully understood, and is only sparingly mentioned e.g., [ 18 , 24 , 25 , 26 , 27 ]. In particular, only three of the reports regard the peripheral structures that could be promising targets for pain relief.…”

Section: Introductionmentioning

confidence: 99%

Single Administration of Melatonin Modulates the Nitroxidergic System at the Peripheral Level and Reduces Thermal Nociceptive Hypersensitivity in Neuropathic Rats

Borsani

Buffoli

Bonazza

et al. 2017

IJMS

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Neuropathic pain is a severe condition with unsatisfactory treatments. Melatonin, an indolamine, seems to be a promising molecule suitable for this purpose due to its well-known anti-inflammatory, analgesic, and antioxidant effects, as well as its modulation of the nitroxidergic system. Nevertheless, the data on its mechanism of action and potentialities are currently insufficient in this pathology, especially at the peripheral level. Thus, this work evaluated the effect of a single administration of melatonin in an established mononeuropathy pain model that monitors the behaviour and the changes in the nitroxidergic system in dorsal root ganglia and skin, which are affected by nervous impairment. Experiments were carried out on Sprague Dawley rats subdivided into the sham operated (control) and the chronic constriction injured animals, a model of peripheral neuropathic pain on sciatic nerve. Single administrations of melatonin (5–10 mg/kg) or vehicle were injected intraperitoneally on the 14th day after surgery, when the mononeuropathy was established. The animals were behaviourally tested for thermal hyperalgesia. The dorsal root ganglia and the plantar skin of the hind-paws were removed and processed for the immunohistochemical detection of neuronal and inducible nitric oxide synthases. The behavioural results showed an increase of withdrawal latency during the plantar test as early as 30 min after melatonin administration. The immunohistochemical results indicated a modulation of the nitroxidergic system both at dorsal root ganglia and skin level, permitting speculate on a possible mechanism of action. We showed that melatonin may be a possible therapeutic strategy in neuropathic pain.

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Evaluation of Electrophysiological Effects of Melatonin and Alpha Lipoic Acid in Rats with Streptozotocine Induced Diabetic Neuropathy

Cited by 12 publications

References 26 publications

Melatonin: new insights on its therapeutic properties in diabetic complications

Melatonin: new insights on its therapeutic properties in diabetic complications

R(+)‐Thioctic Acid Effects on Oxidative Stress and Peripheral Neuropathy in Type II Diabetic Patients: Preliminary Results by Electron Paramagnetic Resonance and Electroneurography

Single Administration of Melatonin Modulates the Nitroxidergic System at the Peripheral Level and Reduces Thermal Nociceptive Hypersensitivity in Neuropathic Rats

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