Evaluation of efficacy, safety and effects on symptoms of androgenization of a generic oral contraceptive containing chlormadinone acetate 2 mg/ethinylestradiol 0.03 mg

Effect of oral contraceptives containing estradiol and nomegestrol acetate or ethinyl-estradiol and chlormadinone acetate on primary dysmenorrhea

“…However, not all COC formulations are equally effective on this complaint. EE/CMA seems one of the formulations providing a more pronounced relief of dysmenorrhea when compared with other hormonal contraceptive formulations [2,[4][5][6]. Its efficacy is probably due to a direct effect of CMA on prostaglandin synthesis, by a down-regulation of COX-2 [2,4] and a specific glucocorticoidal partial activity [2].…”

“…Among all COCs, the monophasic 21/7 regimen COC containing chlormadinone acetate (CMA) in a dosage of 2 mg combined with 30 mcg of ethinyl-estradiol (EE) seems to be one of the most effective preparation [2,4]. The effect of this particular preparation was widely demonstrated in large clinical trials, even when other hormonal contraceptives failed [5,6]. The relevant therapeutic effect has to be ascribed to CMA, which is capable to reduce prostaglandin synthesis by down-regulating the key enzyme cyclo-oxygensae 2 (COX-2) [4].…”