Evaluation of Efficacy of Topical Povidone-Iodine and Different Types of Fluoroquinolones in the Sterilization of Bacterial Flora on the Conjunctiva

Abstract

Ciprofloxacin seems to be more effective in conjunctival sterilization. In consideration with high variety of bacterial flora in pretreatment period in ofloxacin group, ofloxacin seems to be superior to povidone-iodine on the reduction of bacterial flora on the conjunctiva.

A review of preoperative manoeuvres for prophylaxis of endophthalmitis in intraocular surgery

“…Inoue et al [31] found that the most effective protocol in bacteria elimination was the antibiotic used for 3 days preoperation with an iodine conjunctival sac wash. Coskun et al [32] compared 5% PVI, ciprofloxacin, and ofloxacin. They determined that the most effective means of eradicating conjunctival flora was the use of ciprofloxacin, the second was ofloxacin, and the last was 5% PVI solution.…”

Bacterial Contamination of Needles Used for Intravitreal Injections: Comparison between 27-gauge and 30-gauge Needles

“…Several studies also demonstrated that povidone-iodine and different regimens of antibiotics (moxifloxacine, ofloxacin, ciprofloxacin) are highly effective in minimizing conjunctival flora and reducing contamination rate when used just before injections. 20,21 The use of povidone-iodine may be considered a safe prophylaxia as none of our patients developed endophthalmitis. All of our patients received topical ofloxacin 0.3% for postinjection prophylaxis and this regimen was not changed in culture-positive patients as we did not observed any infectious endophthalmitis during the follow-up.…”

Perioperative Antibiotics to Prevent Acute Endophthalmitis after Ophthalmic Surgery: A Systematic Review and Meta-Analysis

“…The detailed screening process is described in Fig 1. Of the remaining reports, there were nine RCTs [13, 30–37] and fourteen observational studies [2, 15–21, 24–29, 38]. A total of 21 studies reported the rate of postoperative endophthalmitis [2, 13, 15–21, 24, 27–29, 38], and 13 studies reported the microbial isolation rate [25, 26, 30–37].…”

“…Of the remaining reports, there were nine RCTs [13, 30–37] and fourteen observational studies [2, 15–21, 24–29, 38]. A total of 21 studies reported the rate of postoperative endophthalmitis [2, 13, 15–21, 24, 27–29, 38], and 13 studies reported the microbial isolation rate [25, 26, 30–37]. Thirty studies [2, 13, 15–21, 24, 27–30, 33–37, 38] included only eyes that received cataract surgery, but an additional four studies [25–26, 31–32] included other intraocular surgeries.…”

“…There were four studies [30–32] that provided a microbial isolation rate, and the results of these studies suggested that there was no significant difference (OR = 0.77, 95% CI (0.34, 1.75), p = 0.53, I2 = 72%) (Fig 3A). A subgroup analysis was performed, but the results were similar (only topical antibiotic: OR = 0.74, 95% CI (0.17, 3.27), p = 0.69, I2 = 83%; topical antibiotic + PVI: OR = 0.77, 95% CI (0.19, 3.09), p = 0.71, I2 = 77%) (Fig 3A).…”