Evaluation of efficacy of non-resorbable membranes compared to resorbable membranes in patients undergoing guided bone regeneration

Patil, Shankargouda; Bhandi, Shilpa; Bakri, Mohammed Mousa H.; Albar, Dhalia Hassan; Alzahrani, Khalid J.; Al-Ghamdi, Mohammad S.; Alnfiai, Mrim M.; Tovani‐Palone, Marcos Roberto

doi:10.1016/j.heliyon.2023.e13488

Cited by 5 publications

(8 citation statements)

References 57 publications

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“…To minimize postoperative problems and maximize treatment success, bone graft materials must be selected based on their effects on vertical defect edema. [ 2 3 4 5 6 ]…”

Section: Introductionmentioning

confidence: 99%

Assessment of Postoperative Edema in Different Bone Graft Cases in Vertical Defects in Periodontal Surgery: An Original Research

Betha,

Rajmohan,

Subhada

et al. 2024

Journal of Pharmacy and Bioallied Sciences

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Background: To replace missing periodontal tissues in vertical defects during periodontal surgery, bone graft materials are frequently used. A frequent occurrence that can affect healing outcomes is postoperative edema. The purpose of this study was to evaluate postoperative edema in various vertical bone graft defects following periodontal surgery. Materials and Methods: 50 participants were split into two groups for a prospective study: Group A received xenografts, whereas Group B received synthetic grafts. Up to 14 days after surgery, baseline and routine postoperative edema measurements were made. Edema levels in each group were compared using statistical analysis. Results: At all postoperative time points, Group A showed substantially more edema than Group B (P < 0.05). Furthermore, edema persisted longer in Group A than it did in Group B. Conclusion: In conclusion, the substance of the bone graft used in vertical defects during periodontal surgery affects postoperative edema. Compared to synthetic grafts, xenografts caused swelling to last longer and at higher levels. To maximize healing results, clinicians should take these findings into account when choosing graft materials.

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“…To minimize postoperative problems and maximize treatment success, bone graft materials must be selected based on their effects on vertical defect edema. [ 2 3 4 5 6 ]…”

Section: Introductionmentioning

confidence: 99%

Assessment of Postoperative Edema in Different Bone Graft Cases in Vertical Defects in Periodontal Surgery: An Original Research

Betha,

Rajmohan,

Subhada

et al. 2024

Journal of Pharmacy and Bioallied Sciences

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“…One widely used method for promoting bone formation is guided bone regeneration (GBR), which is extensively employed to treat mouth and facial area defects, particularly in dental implantology [2]. GBR is utilized as a regenerative technique to enhance ridge volume [3]. Its objective is to selectively attract osteogenic cells to the site of bone defects while excluding cells that might hinder osteogenesis [3].…”

Section: Introductionmentioning

confidence: 99%

“…GBR is utilized as a regenerative technique to enhance ridge volume [3]. Its objective is to selectively attract osteogenic cells to the site of bone defects while excluding cells that might hinder osteogenesis [3]. Therefore, the primary objective of GBR is to establish a specific path for osteoblasts to access the osteogenic region using a barrier membrane.…”

Section: Introductionmentioning

confidence: 99%

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Resorbable GBR Scaffolds in Oral and Maxillofacial Tissue Engineering: Design, Fabrication, and Applications

Alavi,

Gholami,

Shahmabadi

et al. 2023

JCM

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Guided bone regeneration (GBR) is a promising technique in bone tissue engineering that aims to replace lost or injured bone using resorbable scaffolds. The promotion of osteoblast adhesion, migration, and proliferation is greatly aided by GBR materials, and surface changes are critical in imitating the natural bone structure to improve cellular responses. Moreover, the interactions between bioresponsive scaffolds, growth factors (GFs), immune cells, and stromal progenitor cells are essential in promoting bone regeneration. This literature review comprehensively discusses various aspects of resorbable scaffolds in bone tissue engineering, encompassing scaffold design, materials, fabrication techniques, and advanced manufacturing methods, including three-dimensional printing. In addition, this review explores surface modifications to replicate native bone structures and their impact on cellular responses. Moreover, the mechanisms of bone regeneration are described, providing information on how immune cells, GFs, and bioresponsive scaffolds orchestrate tissue healing. Practical applications in clinical settings are presented to underscore the importance of these principles in promoting tissue integration, healing, and regeneration. Furthermore, this literature review delves into emerging areas of metamaterials and artificial intelligence applications in tissue engineering and regenerative medicine. These interdisciplinary approaches hold immense promise for furthering bone tissue engineering and improving therapeutic outcomes, leading to enhanced patient well-being. The potential of combining material science, advanced manufacturing, and cellular biology is showcased as a pathway to advance bone tissue engineering, addressing a variety of clinical needs and challenges. By providing this comprehensive narrative, a detailed, up-to-date account of resorbable scaffolds’ role in bone tissue engineering and their transformative potential is offered.

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“…Some recent studies are focused on designing and examining bioresorbable membranes; however, their fast degradation rate and low mechanical strength go against their extensive application. On the other hand, non‐resorbable GBR membranes such as expanded polytetrafluoroethylene (e‐PTEF), titanium mesh and titanium‐reinforced polytetrafluoroethylene are still attractive regarding their predictable and long‐term clinical outcome (Patil et al, 2023). Of note, lacking osteoinduction potential remains the major issue facing different commercially available barriers (Aprile et al, 2020; Kuwahara et al, 2021; Sheikh et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

In vivo evaluation of bone regeneration using ZIF8‐modified polypropylene membrane in rat calvarium defects

Mousavi

Ejeian

Razmjou

et al. 2023

J Clinic Periodontology

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AimThe profound potential of zeolitic imidazolate framework 8 (ZIF8) thin film for inducing osteogenesis has been previously established under in vitro conditions. As the next step towards the clinical application of ZIF8‐modified substrates in periodontology, this in vivo study aimed to evaluate the ability of the ZIF8 crystalline layer to induce bone regeneration in an animal model defect.Materials and MethodsFollowing the mechanical characterization of the membranes and analysing the in vitro degradation of the ZIF8 layer, in vivo bone regeneration was evaluated in a critical‐sized (5‐mm) rat calvarial bone defect model. For each animal, one defect was randomly covered with either a polypropylene (PP) or a ZIF8‐modified membrane (n = 7 per group), while the other defect was left untreated as a control. Eight weeks post surgery, bone formation was assessed by microcomputed tomography scanning, haematoxylin and eosin staining and immunohistochemical analysis.ResultsThe ZIF8‐modified membrane outperformed the PP membrane in terms of mechanical properties and revealed a trace Zn+2 release. Results of in vivo evaluation verified the superior barrier function of the ZIF8‐coated membrane compared with pristine PP membrane. Compared with the limited marginal bone formation in the control and PP groups, the defect area was almost filled with mature bone in the ZIF8‐coated membrane group.ConclusionsOur results support the effectiveness of the ZIF8‐coated membrane as a promising material for improving clinical outcomes of guided bone regeneration procedures, without using biological components.

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Evaluation of efficacy of non-resorbable membranes compared to resorbable membranes in patients undergoing guided bone regeneration

Cited by 5 publications

References 57 publications

Assessment of Postoperative Edema in Different Bone Graft Cases in Vertical Defects in Periodontal Surgery: An Original Research

Assessment of Postoperative Edema in Different Bone Graft Cases in Vertical Defects in Periodontal Surgery: An Original Research

Resorbable GBR Scaffolds in Oral and Maxillofacial Tissue Engineering: Design, Fabrication, and Applications

In vivo evaluation of bone regeneration using ZIF8‐modified polypropylene membrane in rat calvarium defects

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