Evaluation of efficacy and safety of glycopyrrolate - xylazine - propofol anesthesia in buffalo calves

Abstract

Aim:To evaluate the efficacy and safety of glycopyrrolate - xylazine - propofol anesthesia in buffalo calves.Materials and Methods:The study was conducted on six clinically healthy male buffalo calves, 6-12 months of age, and weighing between 130 and 170 kg. In all the animals; glycopyrrolate (0.01 mg/kg, IM), xylazine (0.1 mg/kg, IM) and 1% propofol as single bolus (1.5 mg/kg, intravenous), were administered. The parameters observed included behavioral changes, physiological; hematological and blood biochemical parameters.Results:Muzzle and nostrils became dry in all the animals after glycopyrrolate administration. A decrease in spontaneous activity and mild cutaneous analgesia was noticed after xylazine administration. After administration of propofol, loss of swallowing reflex, palpebral reflex, corneal reflexes, periosteal reflex and complete analgesia was observed. There was no significant change in rectal temperature and heart rate. However, heart rate remained elevated during anesthesia. Respiratory rate decreased significantly after propofol administration. There was a significant increase in plasma glucose after the xylazine and propofol administration which remained elevated till recovery. A significant decrease in chloride level was seen after propofol administration.Conclusions:Glycopyrrolate - xylazine - propofol anesthetic combination may safely be used for short duration anesthesia in buffalo calves.

Effects of Anaesthetic Protocol on Kidney and Liver Function of Female Dogs undergoing Ovariohysterectomy

“…In the present study, serum globulin and albumin in all four groups showed non-significant decrease at various intervals during an observation period in comparison to the respective baseline values. Potliya et al (2015) also reported similar finding during premedication with glycopyrrolate and xylazine and induction with propofol. This decrease in serum globulin and serum albumin was might be attributable to haemodilution due to continuous fluid therapy during the entire period of observation and shifting of ECF to the intravascular compartment to maintain normal CO during anaesthesia.…”

Application of α2‐adrenergic agonists combined with anesthetics and their implication in pulmonary intravascular macrophages‐insulted pulmonary edema and hypoxemia in ruminants

“…DET at three doses (25, 50, and 75 μg/kg, IV) proves to produce sedation and analgesia in a dose‐dependent manner (El‐Maghraby & Al‐Qudah, 2005). In clinical practice, PRO is usually combined with other analgesic agents such as α 2 ‐adrenergic agonists or opioids to cover its analgesic shortage and short duration of action (Potliya et al, 2015). Induction of general anesthesia with PRO alone (2 mg/kg) or in a combination with either XYL (0.25 mg/kg) or DIAZ (0.25 mg/kg) was assessed.…”

Effects of Intermittent Hot Water Treatment on Cherry Quality

“…The maximum increase in duration of anesthesia along-with smooth induction, excellent muscle relaxation and smooth recovery may be probably attributable through a synergistic action of detomidinemidazolam with propofol-ketamine. The combinations of various pre-anesthetic had been used to prolong the duration of anesthesia along with shorter recovery time, thereby improving quality of anaesthesia (Potliya et al, 2015). Similar findings were also reported in calves (Kilic, 2008) and dogs (Sahoo et al, 2018).…”