Evaluation of effects of perioperative oral care intervention on hospitalization stay and postoperative infection in patients undergoing lung cancer intervention

Ishikawa, Shinya; Yamamori, Iku; Takamori, Satoshi; Kitabatake, Kenichiro; Edamatsu, Kaoru; Sugano, Akira; Oizumi, Hiroyuki; Kato, Hirohisa; Suzuki, Jun; Sato, Kaito; Yusa, Kosuke; Sadahiro, Mitsuaki; Iino, Mitsuyoshi

doi:10.1007/s00520-020-05450-9

Cited by 19 publications

(13 citation statements)

References 38 publications

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“… 56 Oral bacteria increase the risk of postoperative pneumonia and professional oral hygiene practices serve to minimize the risk of postoperative pneumonia in lung and esophageal cancer. 57 , 58 Our findings reveal a novel role of oral bacteria in promoting tumor metastasis. They reinforce the need for professional oral hygiene management in patients with cancer in terms of avoiding not only postoperative pneumonia but also tumor metastasis.…”

Section: Discussionmentioning

confidence: 74%

“…Postoperative pneumonia frequently occurs in hospitalized patients and is intimately associated with postoperative mortality 56 . Oral bacteria increase the risk of postoperative pneumonia and professional oral hygiene practices serve to minimize the risk of postoperative pneumonia in lung and esophageal cancer 57,58 . Our findings reveal a novel role of oral bacteria in promoting tumor metastasis.…”

Section: Discussionmentioning

confidence: 80%

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The oral bacterium Streptococcus mutans promotes tumor metastasis by inducing vascular inflammation

Maishi

Akahori

et al. 2022

Cancer Science

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Recent studies have demonstrated a relationship between oral bacteria and systemic inflammation. Endothelial cells (ECs), which line blood vessels, control the opening and closing of the vascular barrier and contribute to hematogenous metastasis; however, the role of oral bacteria‐induced vascular inflammation in tumor metastasis remains unclear. In this study, we examined the phenotypic changes in vascular ECs following Streptococcus mutans (S. mutans) stimulation in vitro and in vivo. The expression of molecules associated with vascular inflammation and barrier‐associated adhesion was analyzed. Tumor metastasis was evaluated after intravenous injection of S. mutans in murine breast cancer hematogenous metastasis model. The results indicated that S. mutans invaded the ECs accompanied by inflammation and NF‐κB activation. S. mutans exposure potentially disrupts endothelial integrity by decreasing vascular endothelial (VE)‐cadherin expression. The migration and adhesion of tumor cells were enhanced in S. mutans‐stimulated ECs. Furthermore, S. mutans‐induced lung vascular inflammation promoted breast cancer cell metastasis to the lungs in vivo. The results indicate that oral bacteria promote tumor metastasis through vascular inflammation and the disruption of vascular barrier function. Improving oral hygiene in patients with cancer is of great significance in preventing postoperative pneumonia and tumor metastasis.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 80%

The oral bacterium Streptococcus mutans promotes tumor metastasis by inducing vascular inflammation

Maishi

Akahori

et al. 2022

Cancer Science

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“…The incidence of pneumonia after hospitalization in this study was similar at 1.6%. When examining the efficacy of POM in preventing pneumonia by cancer type, POM helps prevent postoperative pneumonia in patients with esophageal, lung, and other cancers [ 17 , 18 , 19 ]. This study showed a reduction in the incidence of pneumonia by approximately 2.6% in patients with lung cancer and 1.0% in patients with head and neck cancer.…”

Section: Discussionmentioning

confidence: 99%

Effects of Perioperative Oral Management in Patients with Cancer

Kurasawa

Iida

Narimatsu

et al. 2022

JCM

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Perioperative oral management (POM) is used to prevent pneumonia in patients with cancer. However, the factors that expose hospitalized patients to increased risk of developing pneumonia remain unclear. For example, no study to date has compared the incidence of pneumonia in hospitalized patients by cancer primary lesion, or POM implementation, or not. We determined which patients were most likely to benefit from POM and examined the effects of POM on pneumonia prevention and mortality. In a total of 9441 patients with cancer who underwent surgery during hospitalization, there were 8208 patients in the No POM group, and 1233 in the POM group. We examined between-group differences in the incidence of pneumonia and associated outcomes during hospitalization. There was no significant between-group difference in the incidence of pneumonitis, however, patients with lung, or head and neck cancers, demonstrated a lower incidence of postoperative pneumonia. Among patients with lung and pancreatic cancers, mortality was significantly lower in the POM group. POM appears effective at reducing the risk of postoperative pneumonia in patients with certain cancers. Further, mortality was significantly lower in patients with lung and pancreatic cancers who received POM; hence, POM may be an effective adjuvant therapy for patients with cancer.

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“…Cancer patients are less aware of their oral health due to fear of death and anxiety about treatment 15 . Oral care during cancer treatment contributes to improving the QOL of cancer patients and reducing healthcare costs 9 by reducing oral complications 6 – 8 , postoperative pneumonia 16 – 18 , and duration of hospital stay 19 , 20 . It is necessary to fully inform patients of the significance of oral care and the benefits of medical–dental collaboration, and to link this to patient behavior.…”

Section: Discussionmentioning

confidence: 99%

Factors influencing patient disclosure of cancer diagnosis to the family dentist: online survey in Japan

Lee

Takase

Fushimi

2022

Sci Rep

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Oral care during cancer treatment constitutes essential supportive care. We aimed to identify factors associated with cancer patients informing their family dentists about their cancer diagnosis. Using the generated original questionnaire, we conducted a cross-sectional questionnaire study in 500 cancer patients (gastric, colorectal, lung, breast, and prostate cancer) through the Internet from September 10 to 13, 2019. The factors influencing patients’ disclosure of their cancer diagnosis to their family dentist were identified by multivariable logistic regression analysis. Nearly half of the respondents (42.2%) informed their family dentist that they had cancer. The disclosing behavior of cancer patients was distinctively associated with their physician’s advice (odds ratio [OR] 59.3; 95% confidence interval [CI] 7.7–456.3); 8.6% of all respondents were advised to inform their dentist about their cancer diagnosis. In the group without the physician's advice, good relationship with family dentist was associated with disclosing behavior. This study indicates the need for support for cancer patients to receive appropriate oral care; patients' perceptions of the physician’s advice and communication with the family dentist should be motivators for disclosing the cancer diagnosis to dentists. Medical workers involved in cancer care should demonstrate the benefit of medical-dental collaboration in cancer care of patients.

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Evaluation of effects of perioperative oral care intervention on hospitalization stay and postoperative infection in patients undergoing lung cancer intervention

Cited by 19 publications

References 38 publications

The oral bacterium Streptococcus mutans promotes tumor metastasis by inducing vascular inflammation

The oral bacterium Streptococcus mutans promotes tumor metastasis by inducing vascular inflammation

Effects of Perioperative Oral Management in Patients with Cancer

Factors influencing patient disclosure of cancer diagnosis to the family dentist: online survey in Japan

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