Evaluation of Effects of Dietary n‐6 to n‐3 Fatty Acid Ratios on Leukotriene B Synthesis in Dog Skin and Neutrophils

Vaughn, Dana M.; Reinhart, Gregory A.; Swaim, Steven F.; Lauten, Susan D.; Garner, Carl A.; Boudreaux, Mary K.; Spano, J. S.; Hoffman, Charles E.; Conner, Brenda

doi:10.1111/j.1365-3164.1994.tb00028.x

Cited by 79 publications

(75 citation statements)

References 49 publications

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“…The level of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids in plasma lipids increases at the expense of arachidonic acid (AA) (Herold and Kinsella, 1986;Fritsche et al, 1993;Das, 2002;Kankaanpaa et al, 2004) with a more pronounced effect of DHA compared to that of EPA (Morisaki et al, 1983). The mechanism of action of ω-3 PUFA on plasma lipids has not (Nestel, 1986) or the production of very low-density lipoproteins (VLDL) (Harris et al, 1984;Vaughn et al, 1994). The structure of PUFA in immune system cells indicates their potential influence on biological receptors, signal transduction and lymphocyte proliferation (Vaughn et al, 1994;Kelley, 2001).…”

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confidence: 99%

“…The mechanism of action of ω-3 PUFA on plasma lipids has not (Nestel, 1986) or the production of very low-density lipoproteins (VLDL) (Harris et al, 1984;Vaughn et al, 1994). The structure of PUFA in immune system cells indicates their potential influence on biological receptors, signal transduction and lymphocyte proliferation (Vaughn et al, 1994;Kelley, 2001). Probiotic bacteria are known for their action on the host body including its immune system (Fuller, 1992).…”

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confidence: 99%

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The effect of probiotics potentiated with polyunsaturated fatty acids on the digestive tract of germ-free piglets

Kasteĺ¹,

Bomba²,

Vaško³

et al. 2007

Vet. Med. - Czech

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ABSTRACT:Oil with higher a content of ω-3 polyunsaturated fatty acids (PUFA) was administered for 4 weeks to experimental germ-free piglets and from 21 days of age the piglets were inoculated perorally with probiotic microorganisms Lactobacillus casei subsp. casei. Control piglets were administered saline solution in identical doses and starting from the fourth week were also supplemented with probiotics. At the age of 28 days, the number of Lactobacillus casei subsp. casei that had adhered to jejunal mucosa of experimental piglets was significantly higher (P < 0.05) compared to that in the control group. The differences in the number of lactobacilli, which colonised mucosa of the ileum and colon of experimental and control piglets, were insignificant. With the exception of the stomach, the pH level in the digestive tract of piglets was lower in the experimental piglets. Significantly higher levels of propionic (P < 0.05), acetoacetic and succinic (P < 0.01) acids were observed in germ-free experimental piglets in colon. The differences in the level of lactic and acetic acid were insignificant. PUFA-potentiated probiotics positively affected the adhesion of lactobacilli, pH and the level of organic acids in the digestive tract of germ-free piglets. Supplementation of oil containing ω-3 PUFA significantly increased the blood level of α-linolenic, eicosapentaenoic and docosahexaenoic acids in experimental piglets at the expense of arachidonic acid in comparison with the control.

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confidence: 99%

mentioning

confidence: 99%

The effect of probiotics potentiated with polyunsaturated fatty acids on the digestive tract of germ-free piglets

Kasteĺ¹,

Bomba²,

Vaško³

et al. 2007

Vet. Med. - Czech

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“…Uma vez liberados pela fosfolipases estes vão competir pela lipoxigenase e cicloxigenase e este balanço irá determinar a produção de mediadores mais ou menos inflamatórios. Assim, além da quantidade absoluta de EPA e DHA, sua relação no alimento com os ácidos graxos ômega-6, em especial o ácido araquidônico é também bastante importante e deve ser considerada na formulação do perfil de ácidos graxos do alimento (VAUGHN et al, 1994).…”

Section: áCidos Graxos Poliinsaturados ôMega-3unclassified

Nutracêuticos imunomoduladores com potencial uso clínico para cães e gatos

et al. 2014

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ResumoTem-se observado o uso crescente de nutracêuticos em medicina veterinária, para auxiliar no tratamento clínico. Esta revisão teve como objetivo descrever alguns nutracêuticos que atuam sobre a imunidade de cães e gatos e levantar os possíveis benefícios como tratamento adjuvante para determinadas enfermidades. A ação de derivados de levedura tem sido bastante avaliada, especialmente da fração beta-glucano, um potente imunomodulador, com ação já demonstrada em cães e gatos, sendo benéfico no tratamento de algumas doenças. Os ácidos graxos poliinsaturados ômega-3, talvez os mais utilizados atualmente, podem trazer benefícios no tratamento de hipertensão, doenças renais e cardíacas, artrites, doenças autoimunes, doenças gastrintestinais e câncer. A vitamina E apresenta ação antioxidante e imunomoduladora, podendo auxiliar no tratamento de doenças dermatológicas e hepatobiliares. O uso de carotenoides, que tem ação semelhante à da vitamina E, pode ser interessante por serem potentes antioxidantes, podem ajudar na melhora da resposta imune contra microrganismos e, também, na prevenção do aparecimento de tumores. Apesar de ainda serem necessários mais estudos clínicos para se entender os reais benefícios trazidos pela suplementação dos nutracêuticos em cada doença específica, a compreensão dos mecanismos de ação destes indica que são promissores para uso clínico. Palavras-chave: Ácidos graxos poliinsaturados ômega-3, Beta-glucano, carotenoides, imunidade, vitamina E AbstractThe use of nutraceuticals in veterinary medicine is growing and is assumed that they could aid in clinical treatment. This review aims to describe some nutraceuticals that act on the immunity of dogs and cats and show the possible benefits as an adjuvant treatment for some diseases. The action of some yeast derivates as immunomodulators, especially the beta-glucan fraction, was already proved to occur in dogs and cats, being beneficial as an adjuvant therapy in many clinical conditions. Omega-3 polyunsatured fatty acids, possibly the mostly used nutraceuticals, can improve the condition in some diseases, such as hypertension, renal, cardiac, gastrointestinal and autoimmune diseases, arthritis and cancer. Vitamin E has antioxidant and immunomodulatory action and can aid in the treatment

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“…52 Omega-3 fatty acid-enriched diets have also been shown to modify the biochemical components of the inflammatory stage of wound healing in the skin of dogs. Using a dietary approach in which the quantity and the ratio of omega-6 and omega-3 fatty acids are controlled may be an effective means of altering tissue eicosanoid profiles and reducing pruritus in some allergic pets.…”

Section: Diet Modificationmentioning

confidence: 99%

Nutritionally Responsive Dermatoses

Case¹

2011

Canine and Feline Nutrition

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Evaluation of Effects of Dietary n‐6 to n‐3 Fatty Acid Ratios on Leukotriene B Synthesis in Dog Skin and Neutrophils

Cited by 79 publications

References 49 publications

The effect of probiotics potentiated with polyunsaturated fatty acids on the digestive tract of germ-free piglets

The effect of probiotics potentiated with polyunsaturated fatty acids on the digestive tract of germ-free piglets

Nutracêuticos imunomoduladores com potencial uso clínico para cães e gatos

Nutritionally Responsive Dermatoses

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