Evaluation of Effectiveness of Photodynamic Therapy With Low-level Diode Laser in Nonsurgical Treatment of Peri-implantitis

Abstract

Introduction: Side effects related to antibiotic therapy for peri-implantitis are rare in laser therapy (LT); therefore, the aim of this study was to evaluate the effectiveness of LT and photodynamic therapy (PDT) on patients with primary peri-implantitis. Methods: In this randomized clinical trial, 40 implants presenting primary peri-implantitis in 20 patients with a mean age of 52.6 years old were included using the simple sampling technique. Periodontal treatment comprising scaling and root planing (SRP) was accomplished for the whole mouth while mechanical debridement with titanium curettes and air polishing with sodium bicarbonate powder was accomplished around the implants. The implants were randomly divided into two groups and treated with LT (control) and PDT (test). The clinical indices were measured at baseline, 6 weeks and 3 months after treatment. Real-time polymerase chain reaction (PCR) was used for analysis of microbial samples at baseline and 3-month follow-up. Data were analyzed with SPSS 20, using repeated-measures analysis of variance (ANOVA) and Friedman's and MannWhitney tests (α = 0.05). Results: Both groups showed statistically significant improvements in terms of bleeding on probing (P < 0.001), probing pocket depth (PPD) (P = 0.006) and modified plaque index (P < 0.001), with no significant differences between the 2 groups (P > 0.05). The number of Aggregatibacter actinomycetemcomitans (P = 0.022), Tannerella forsythia (P = 0.038) and Porphyromonas gingivalis (P = 0.05) in the test group and Porphyromonas gingivalis (P = 0.015) in the control group significantly decreased. Conclusion:The results suggested that LT and PDT have significant short-term benefits in the treatment of primary peri-implantitis.

Adjunctive Use of Lasers in Peri-Implant Mucositis and Peri-Implantitis Treatment: A Systematic Review

“…In the current literature, there is a high number of published clinical studies reporting the adjunctive use of lasers in combination with conventional debridement in the treatment of peri-implant inflamed tissues with promising results [ 38 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 ]. The findings of the present systematic review are in agreement with the above-mentioned literature.…”

Disinfect Porphyromonas gingivalis Biofilm on Titanium Surface with Combined Application of Chlorhexidine and Antimicrobial Photodynamic Therapy

“…aPDT has already been successfully used as an adjuvant protocol in eradicating pathogenic bacteria from caries , endodontic or periodontal origins. During the past two decades, aPDT has also been introduced into peri‐implantitis treatment as an adjunct therapy in an increasing number of studies . Previous in vitro studies have demonstrated that aPDT could exert its bacteriostatic effect at varying depths throughout the P. gingivalis biofilm but could not achieve a bactericidal effect .…”

Adjunctive therapies for the nonsurgical treatment of peri-implant diseases: systemic review and meta-analysis

“…Implant supported prosthesis design is important to promote accessibility to oral hygiene around implants [50], which suggests a way to treat peri- After comparing different adjunctive therapies, we found that the use of ERL or repeated minocycline microspheres as an adjunct to MD treatment for peri-implantitis is better than chlorhexidine gel [12,28]. Adjunct use of photodynamic therapy was as effective as one unit-dosage of minocycline microspheres or diode laser after 6 months of follow-up [15,21,22]. The efficacy of probiotics as an adjunct to the MD treatment was better than that of systemic antibiotics in reducing PPD and mBI.…”