Evaluation of effectiveness of dexmedetomidine and fentanyl-midazolam combination on sedation and safety during awake fiberoptic intubation: A randomized comparative study

Abstract

Background:Awake fiberoptic intubation (AFOI) is a recommended technique for anticipated difficult airway. An ideal regime should provide patient comfort, cooperation, amnesia, hemodynamic stability, and blunt airway reflexes and maintain a patent airway with spontaneous ventilation. The aim of our study was to compare intubation conditions between dexmedetomidine and fentanyl–midazolam combination during AFOI.Methods:This prospective, randomized study was conducted on a total of sixty patients of the American Society of Anesthesiologists physical status I and II of either sex, in the age group of 18–60 years having predicted difficult intubation undergoing elective surgeries and the patients were allocated to two groups of thirty patients each. After premedication and topicalization of airways, dexmedetomidine group (Group I, n = 30) received dexmedetomidine 1 μg/kg over 10 min and midazolam–fentanyl group (Group II, n = 30) received fentanyl 2 μg/kg plus midazolam 0.02 mg/kg over 10 min. Adequacy of intubation condition was evaluated by cough score and postintubation score. Incidence of desaturation, hemodynamic changes, and sedation using Ramsay sedation scale were noted and compared between two groups.Results:The demographic characteristics were comparable in the two groups (P > 0.05). The mean Ramsay sedation score in Group I was 3.13 ± 0.937 and Group II was 3.16 ± 0.949, and the comparison between two groups was statistically insignificant (P = 0.891). Cough scores and postintubation scores were favorable in dexmedetomidine group than midazolam–fentanyl group and were statistically significant with P < 0.001 and 0.0001, respectively. Group I also showed better hemodynamics and less episodes of desaturation than Group II.Conclusions:Dexmedetomidine is more effective than midazolam–fentanyl during AFOI, as it provides better intubation condition, hemodynamic stability, and preservation of airway and spontaneous ventilation.

A randomized controlled study comparing dexmedetomidine-midazolam with fentanyl-midazolam for sedation during awake fiberoptic intubation in anticipated difficult airway

“…Similar to our study, Yousuf et al . [ 16 ] reported less episodes of desaturation in dexmedetomidine group (17%) compared to FM group where this was found to be around 40%. Another study done by Agrawal et al .…”

Awake fiberoptic intubation and use of bronchial blockers in ankylosing spondylitis patients

“…Rational drug sedation can reduce anxiety and discomfort in patients and increase their tolerance to the intubation process[ 15 ]. The most commonly used sedation solution is a combination of fentanyl (2 µg/kg) and midazolam (0.02 mg/kg), titrated according to the patient's needs[ 16 ]. Midazolam is used for sedation and prevention of seizures in cases of local anesthetic poisoning.…”

A comparative study of midazolam alone or in combination with dexmedetomidine or clonidine for awake fiberoptic intubation

“…Injection midazolam has been used in a dose range of 0.02–0.05 mg/kg in several studies, both as intravenous bolus and infusion. [520] The dose of injection dexmedetomidine as loading infusion of 1 μg/kg and maintenance infusion of 0.2–0.7 μg/kg/h is quite established. We used loading dose of 1 μg/kg and maintenance dose of 0.5 μg/kg/h in our study.…”

“…We used loading dose of 1 μg/kg and maintenance dose of 0.5 μg/kg/h in our study. [57810202122] Injection clonidine is mostly used as intravenous bolus but can also be used as infusion. Srivastava et al have used injection clonidine in a dose of 1-2 μg/kg/h in their study.…”