Evaluation of Effect of Ninjin'yoeito on Regional Brain Glucose Metabolism by 18F-FDG Autoradiography With Insulin Loading in Aged Mice

Zhao, Jingmin; Imai, Ryota; Ukon, Naoyuki; Shimoyama, Saki; Tan, Chengbo; Maejima, Yuko; Omiya, Yuji; Takahashi, Kazuhiro; Guo, Nan; Ito, Hiroshi; Shimomura, Kenju

doi:10.3389/fnut.2021.657663

Cited by 2 publications

(3 citation statements)

References 62 publications

(96 reference statements)

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“…Clinical trials also found RSYRT to be effective in improving fatigue symptom (Xu et al, 2020 ), and anti-microinflammation in haemodialysis patients (Hsiao et al, 2015 ). Moreover, RSYRT demonstrated anti-aging effects via improving insulin resistance in the brain (Zhao, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Real-world Chinese herbal medicine for Parkinson's disease: a hospital-based retrospective analysis of electronic medical records

Lyu,

Zhang,

Mao

et al. 2024

Front. Aging Neurosci.

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BackgroundParkinson's disease (PD) is a progressive neurodegenerative condition. Chinese medicine therapies have demonstrated effectiveness for PD in controlled settings. However, the utilization of Chinese medicine therapies for PD in real-world clinical practice and the characteristics of patients seeking these therapies have not been thoroughly summarized.MethodThe study retrospectively analyzed initial patient encounters (PEs) with a first-listed diagnosis of PD, based on electronic medical records from Guangdong Provincial Hospital of Chinese Medicine between July 2018 and July 2023.ResultsA total of 3,206 PEs, each corresponding to an individual patient, were eligible for analyses. Approximately 60% of patients made initial visits to the Chinese medicine hospital after receiving a PD diagnosis, around 4.59 years after the onset of motor symptoms. Over 75% of the patients visited the Internal Medicine Outpatient Clinic at their initial visits, while a mere 13.85% visited PD Chronic Care Clinic. Rest tremor (61.98%) and bradykinesia (52.34%) are the most commonly reported motor symptoms, followed by rigidity (40.70%). The most commonly recorded non-motor symptoms included constipation (31.88%) and sleep disturbance (25.27%). Integration of Chinese medicine and conventional medicine therapies was the most common treatment method (39.15%), followed by single use of Chinese herbal medicine (27.14%). The most frequently prescribed herbs for PD included Glycyrrhiza uralensis Fisch. (gan cao), Astragalus mongholicus Bunge (huang qi), Atractylodes macrocephala Koidz. (bai zhu), Angelica sinensis (Oliv.) Diels (dang gui), Rehmannia glutinosa (Gaertn.) DC. (di huang), Paeonia lactiflora Pall. (bai shao), Bupleurum chinense DC. (chai hu), Citrus aurantium L. (zhi qiao/zhi shi/chen pi), Panax ginseng C. A. Mey. (ren shen), and Poria cocos (Schw.) Wolf (fu ling). These herbs contribute to formulation of Bu zhong yi qi tang (BZYQT).ConclusionPatients typically initiated Chinese medical care after the establishment of PD diagnosis, ~4.59 years post-onset of motor symptoms. The prevalent utilization of CHM decoctions and patented Chinese herbal medicine products, underscores its potential in addressing both motor and non-motor symptoms. Despite available evidence, rigorous clinical trials are needed to validate and optimize the integration of CHM, particularly BZYQT, into therapeutic strategies for PD.

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Section: Discussionmentioning

confidence: 99%

Real-world Chinese herbal medicine for Parkinson's disease: a hospital-based retrospective analysis of electronic medical records

Lyu,

Zhang,

Mao

et al. 2024

Front. Aging Neurosci.

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“…Previous studies indicated that NYT ameliorated dementia or depression/anxiety [94][95][96] by increasing the levels of neurotrophic factors [94,97], attenuating the inhibition of neurogenesis [95,98], suppressing microglial overactivity [99], increasing cerebral blood flow [100], and enhancing cerebral glucose metabolism [92]. Furthermore, NYT improved diminished motivation [86,87,101,102] and suppressed the hypothalamic-pituitary-adrenal (HPA) axis by downregulating the sympathetic-adrenal-medullary (SAM) axis and GABA neurons to improve sociability [103].…”

Section: Psychological Frailtymentioning

confidence: 99%

“…Other studies showed improvements in walking ability [85, 90] and locomotor activity [85, 90]. NYT has been shown to attenuate insulin resistance [91–93] and may also be effective against aging‐related impairments in glucose metabolism/sarcopenia.…”

Section: Preclinical Studies On Nytmentioning

confidence: 99%

Review of frequently used Kampo prescriptions: Part 4, Ninjin'yoeito

Takayama,

Michihara,

Kimura

et al. 2023

Traditional & Kampo Medicine

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BackgroundThe source of ninjin'yoeito (NYT) is considered the ‘Formulary of Bureau of Taiping People's Welfare Pharmacy’, written around 1241–52 AD. NYT is used to treat patients with chronic fatigue, malaise with qi deficiency, and exhaustion of all five parenchymatous viscera with difficulty in recovering.Key FindingsNYT formula consists of 12 crude drugs. NYT extract for medical use is covered by the National Health Insurance system of Japan for convalescence after recovery from diseases, fatigue and malaise, anorexia, perspiration during sleep, cold limbs, and anemia. Studies have shown clinical effects of NYT: treatment of anemia, cancer treatment support, frailty, cognitive dysfunction, apathy, fatigue/malaise, anorexia, and lung diseases. Preclinical studies support clinical studies; activating ghrelin‐neuropeptide Y pathway‐mediated appetite‐enhancing effects, inhibiting muscle volume loss through the Akt/mTOR pathway‐mediated hyperphosphorylation of 4E‐BP1 and FoxO1‐mediated Atrogin‐1, suppressing the hypothalamic–pituitary–adrenal axis by downregulating the sympathetic‐adrenal‐medullary axis and GABA neurons for improving sociability, promoting recovery from skeletal muscle atrophy through the activation of PGC‐1α, hematopoiesis‐promoting effects, and increasing the number of immune cells in immunocompromised models. The incidence of adverse events of NYT was reported as 3.09 or 2.03%. The most significant adverse effects of NYT are gastrointestinal disorders.ConclusionRecently, NYT has been widely used to treat several symptoms and conditions under the National Health Insurance System of Japan. Clinical studies showed the efficacy of NYT to treat anemia, frailty, cognitive dysfunction, anorexia, apathy, and fatigue/malaise, as well as for long‐term cancer treatment support. The pharmacological mechanisms supporting its effects are also being reported.

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Evaluation of Effect of Ninjin'yoeito on Regional Brain Glucose Metabolism by 18F-FDG Autoradiography With Insulin Loading in Aged Mice

Cited by 2 publications

References 62 publications

Real-world Chinese herbal medicine for Parkinson's disease: a hospital-based retrospective analysis of electronic medical records

Real-world Chinese herbal medicine for Parkinson's disease: a hospital-based retrospective analysis of electronic medical records

Review of frequently used Kampo prescriptions: Part 4, Ninjin'yoeito

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