Evaluation of dyslipidaemia in patients with rheumatoid arthritis in South Indian population

Vinapamula, Kiranmayi S; Manohar, Suchitra M.; Bitla, Aparna R.; Kanduri, Rajyalakshmi; Bhattaram, Siddartha Kumar; Pemmaraju, Srinivasa Rao V L N

doi:10.1016/j.injr.2013.06.006

Cited by 6 publications

(7 citation statements)

References 34 publications

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“…It may be due to the effect of lipid-lowering agents in RA patients. The result was consistent with another study [ 25 ]. However, there was a relative elevation of indices among patients than apparently healthy control group.…”

Section: Discussionsupporting

confidence: 94%

Association of atherogenic indices with C-reactive protein and risk factors to assess cardiovascular risk in rheumatoid arthritis patient at Tikur Anbessa Specialized Hospital, Addis Ababa

Dessie

2022

PLoS ONE

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Background Rheumatoid arthritis (RA) is an autoimmune systemic chronic inflammatory disorder, which is characterized by joint stiffness, damage, and destruction of bone. In RA patients, the risk of cardiovascular disease is increased by 2–3 folds as compared to the general population. The major burden of RA is the development of cardiovascular diseases, including congestive heart failure, stroke, and myocardial infarction. Objectives Assessment of the association of atherogenic indices with C-reactive protein to evaluate CVD risk was one of the purposes of this study. In addition, the association of atherogenic indices with elevated levels of cardiovascular risk factors (LDL-C and TG) was another aim of this study. Methods The preferred study design for this study was a hospital based comparative cross-sectional study method. Data were cleaned, coded, and entered into Epi Data version 4.6 software, and exported to SPSS version 20 for further analysis of atherogenic indices, C-reactive protein, and risk factors. The comparison of atherogenic indices and other variables among the case and control groups was estimated by the independent t-test statistical analysis method. All variables with a p-value less than 0.2 during binary linear regression analysis were selected for multinomial logistic regression analysis. The association of atherogenic indices with C-reactive protein and risk factors was computed using multiple logistic regressions. The data were presented using tables and figures for clarification of the study. Results The levels of atherogenic indices were computed for both RA patients and the control group. The values of atherogenic indices were significantly associated with cardiovascular risk factor (CRP ≥ 2mg/L). Atherogenic index of plasma (AIP) and TC/HDL-C ratio had a statistically significant association with an elevated levels of triglycerides (P<0.01). The TC/HDL-Cratio value of the patient had 2.38 folds more likely to have an elevated low density lipoprotein level. In addition, AIP of RA patients had 57.51 and 23.65 folds more to have elevated low density lipoprotein and triglycerides respectively. Conclusions The result of this study showed that TC/HDL-C, LDL/HDL-C ratio values, and atherogenic index of plasma had a statistically significant association with elevated level of low density lipoprotein and triglycerides. In addition to this, they have a statistically significant association with the level of C-reactive protein. There was a highly significant statistical association between atherogenic indices, elevated low density lipoprotein, and triglycerides values. Therefore, the result of this finding confirmed that atherogenic indices have a potential role in the prediction and management of CVD risk in RA patients.

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Section: Discussionsupporting

confidence: 94%

Association of atherogenic indices with C-reactive protein and risk factors to assess cardiovascular risk in rheumatoid arthritis patient at Tikur Anbessa Specialized Hospital, Addis Ababa

Dessie

2022

PLoS ONE

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“…A statistically significant but negative correlation was found between CRP and total cholesterol (-0.414), LDL cholesterol (-0.442) and HDL cholesterol (-0.588) which was in accordance with studies done by Douglas et al [21], Robertson J et al [22] and Athanasios et al [18,20,22] have found no such correlation. VLDL cholesterol and TG were found to have no significant relationship with ESR and CRP.…”

Section: Resultssupporting

confidence: 90%

“…Low HDL-C in the study patients could be as a result of genetic/ environmental factors, wherein HDL-C is low in overall population in this part of the world. Mean triglycerides were 224 mg/dl which were in accordance with the previous studies [17,20]. The mean atherogenic index (TC/HDL) of 4.98, suggests a low CV risk (>5 suggests increased risk), while as mean TC/HDL-C ratio was 5.28 in Muzahim et al [19], but the mean inflammatory markers were increased in their study patients.…”

Section: Resultssupporting

confidence: 89%

Lipid Profile in Rheumatoid Arthritis and its Relation with Inflammatory Markers

Sar¹,

Ms²,

Khaliq³

et al. 2017

Insights in Biomed

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“…On assessing the LDL cholesterol level, no significant difference was found in between the cases and controls although cases had a lower level of LDL cholesterol (82.00± 13.36 mg/dl) than controls (87.19± 15.61 mg/dl). Our finding is similar to Vinapamula et al (2013) 5 where they observed that RA patients had low total cholesterol (115.67 ± 34.85 mg/dl) when compared to controls (125.48 ± 30.80 mg/dl) although not significant statistically. Mahdi et al (2012) 19 , Kowsalya et al (2011) 18 and Mullick et al (2014) 22 have reported significantly higher level of LDL cholesterol in cases than controls.…”

Section: Discussion:-supporting

confidence: 91%

“…Boers et al (2003) 21 reported that the HDL cholesterol level in patients with active disease was significantly lower than patients in remission (0.94±0.31 mmol/l vs 1.18±0.13 mmol/l). However, Vinapamula et al (2013) 5 found no difference in the HDL cholesterol level in between cases and controls.…”

Section: Discussion:-mentioning

confidence: 93%

Correlative Study Between Lipid Profile and Disease Activity in Patients With Rheumatoid Arthritis – A Hospital Based Study.

Yadav¹,

Goswami²,

Bora³

2018

IJAR

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To study the serum lipid profile, disease activity and their correlation in patients with Rheumatoid Arthritis. Materials and methods: The study was carried out on 50 diagnosed patients of RA in the Department of Biochemistry, Assam Medical College and hospital, Dibrugarh. 50 apparently age and sex matched individuals were taken as controls. Fasting lipid profile (Total cholesterol, HDL-c, LDL-c, Triglyceride) was estimated in semiautoanalyser using standard method. Disease activity was assessed by DAS28 ESR score. Results: Serum total cholesterol (TC) and HDL-c were significantly lower in cases than controls (p<0.05 and p<0.01 respectively). Patients with active disease had significantly lower level of TC and HDL-c than those in remission. Triglyceride levels was significantly higher in cases than controls (p<0.05). Conclusion: Study reveals that the lipid profile is altered in Rheumatoid arthritis characterized by low TC, HDL and elevated triglycerides. Further in active cases the mean serum level of total cholesterol and HDL cholesterol were significantly lower than cases in remission. A significant negative correlation was seen between HDLc and DAS28.

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Evaluation of dyslipidaemia in patients with rheumatoid arthritis in South Indian population

Cited by 6 publications

References 34 publications

Association of atherogenic indices with C-reactive protein and risk factors to assess cardiovascular risk in rheumatoid arthritis patient at Tikur Anbessa Specialized Hospital, Addis Ababa

Association of atherogenic indices with C-reactive protein and risk factors to assess cardiovascular risk in rheumatoid arthritis patient at Tikur Anbessa Specialized Hospital, Addis Ababa

Lipid Profile in Rheumatoid Arthritis and its Relation with Inflammatory Markers

Correlative Study Between Lipid Profile and Disease Activity in Patients With Rheumatoid Arthritis – A Hospital Based Study.

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