Evaluation of dry eye and meibomian gland dysfunction with meibography in vitiligo

Palamar, Melis; Kiyat, Pelin; Ertam, İlgen; Yağcı, Ayşe

doi:10.1038/eye.2017.38

Cited by 21 publications

(32 citation statements)

References 15 publications

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“…Nevertheless, our work supports the fact that periocular skin involvement in vitiligo patients is not a predictor of eye affection, a topic that has been studied with conflicting results in the past years. [19][20][21] Our data demonstrate a significantly lower CDVA in vitiligo patients when compared to age-and sex-matched controls. We could find two studies with ophthalmic assessment of vitiligo patients that included visual acuity comparisons with controls, and in both studies, the results showed that the difference was not statistically significant.…”

Section: Discussionmentioning

confidence: 49%

<p>Assessment of the Effect of Vitiligo on Subfoveal Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography</p>

Fouad

Salman

Mohamed

et al. 2020

OPTH

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Background: Vitiligo is a common skin condition affecting 0.5-2% of the population. The exact etiology of the condition is unknown, but the result is autoimmune destruction of melanocytes. The eye is rich in melanocytes, especially in the retinal pigment epithelium and choroid. Little is known about the effect of vitiligo on the choroid of the eye. Methods: We cross-sectionally examined 31 right eyes of 31 vitiligo patients and 32 right eyes of 32 age-and sex-matched controls for signs of vitiligo affection and then measured the subfoveal choroidal thickness (SFCT) using spectral-domain optical coherence tomography. Results: There was a statistically significant difference between SFCT in the cases group and the control group (Mean ± SD: 251.9 ± 42.0 μm and 296.8 ± 46.4 μm, respectively, p = 0.0002). The thickness correlated negatively with age (r = −0.5) but did not correlate significantly with disease severity or duration (r = −0.201, −0.1781, p = 0.2783, 0.3381, respectively). Additional examination findings included iris and fundus hypopigmented spots, and peripapillary atrophy. Conclusion: SFCT is reduced among patients with vitiligo. The clinical implications of such a finding should be studied further, and eye screening programs should be considered.

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Section: Discussionmentioning

confidence: 49%

<p>Assessment of the Effect of Vitiligo on Subfoveal Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography</p>

Fouad

Salman

Mohamed

et al. 2020

OPTH

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“…Palamar et al 19 reported that OSDI score was higher while mean TBUT and Schirmer values were lower in vitiligo. The latter finding is similar to our results.…”

Section: Discussionmentioning

confidence: 98%

Dry Eye and Meibomian Glands in Vitiligo

Taheri¹,

Allahyari²,

Rudi³

et al. 2021

tjo

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Objectives: To evaluate aqueous and lipid tear film parameters and the meibomian glands (MGs) with non-contact meibography in patients with vitiligo. Materials and Methods: This case-control study was conducted in the right (OD) and left (OS) eyes of 43 patients with vitiligo and 43 controls in Birjand, Iran. In addition to demographic information and skin disease characteristics, the Ocular Surface Disease Index (OSDI) questionnaire was completed for each patient, followed by eye examinations including slit lamp examination, Schirmer test, strip meniscometry (SMTube), and tear break-up time (TBUT) measurement. The MGs were also imaged using a non-contact meibography system (SBM System, Italy). The data were analyzed using SPSS version 22.0 with a significant level of less than 0.05. Results: Patients had higher OSDI score than controls but it was not significant (10.90±13.03 vs. 5.57±6.85; p=0.07). There were significant differences between the groups in mean Schirmer test values for both eyes (OD: 8.07±5.47 vs. 17.37±6.52; OS: 7.60±5.00 vs. 17.30±6.44, p<0.001) and mean SMTube results (OD: 4.49±2.40 vs. 9.74±3.67; OS: 4.30±2.81 vs. 9.65±4.52; p<0.001). However, mean TBUT did not differ between the groups (OD: 9.14±3.17 vs. 10.12±2.08, p=0.27; OS: 9.16±3.30 vs. 10.05±2.10, p=0.25). Meibography also showed no significant difference in MG dropout between the groups (OD: 20.86±9.79 vs. 21.05±12.07; p=0.74; OS: 18.16±8.83 vs. 19.53±10.30; p=0.51). Conclusion: Vitiligo is associated with a reduction in the production of aqueous tear film, but does not affect the structure and function of the MGs.

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“…Moreover, all participants were young with a mean age of 34 years and none of them reported any menopausal or hormonal effects [7]. It can also be suggested that the lack of any systemic or dermatologic diseases in either male or female participants might have affected the study outcomes [8][9][10].…”

Section: Discussionmentioning

confidence: 99%

Impact of Prolonged Face Mask Wearing On Tear Break-Up Time and Dry Eye Symptoms in Health Care Professionals

Barış

Yılmaz

Palamar

2021

Preprint

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Purpose To evaluate the impact of prolonged surgical face mask wearing on dry eye symptoms and tear film break-up time (T-BUT) in health care professionals. Materials and Methods A total of 33 health care professionals were included in this cross sectional, prospective study. T-BUT measurements were performed twice for all participants in the morning (8 am) and in the afternoon (5 pm) in addition to a complete ophthalmological examination. The subjects also filled-in the ocular surface disease index (OSDI) questionnaire twice, before and after wearing the face mask, on the same day. Results Sixty six eyes of 33 participants (17 female and 16 male) were evaluated. The mean age was 33.6 ± 7.55 (24–48) years and mean total duration with mask on between the two evaluations was 514 ± 12.5 (495–526) minutes. The mean T-BUT was 9.3 ± 1.0 (3–16) seconds at 8 am and 8.3 ± 1.5 (3–14) seconds at 5 pm (p = 0.01). The mean OSDI score was 20.1 ± 8.3 (0-68.75) at 8 am and 27.4 ± 10.4 (0-81.25) at 5 pm (p < 0.01). Conclusion Use of a surgical mask for the entire work day was seen to worsen T-BUT and dry eye symptoms in healthy individuals. Ophthalmologists should be aware of possible worsening of condition in patients with dry eye with the prolonged use of face masks and consider modifications if necessary.

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Evaluation of dry eye and meibomian gland dysfunction with meibography in vitiligo

Cited by 21 publications

References 15 publications

<p>Assessment of the Effect of Vitiligo on Subfoveal Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography</p>

<p>Assessment of the Effect of Vitiligo on Subfoveal Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography</p>

Dry Eye and Meibomian Glands in Vitiligo

Impact of Prolonged Face Mask Wearing On Tear Break-Up Time and Dry Eye Symptoms in Health Care Professionals

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