Evaluation of drug–drug interaction screening software combined with pharmacist intervention

Moura, Cristiano Soares de; Prado, Nília Maria de Brito Lima; Belo, Najara O.; Acúrcio, Francisco de Assis

doi:10.1007/s11096-012-9642-2

Cited by 35 publications

(37 citation statements)

References 28 publications

(26 reference statements)

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“…This justifies the elevated number of publications in this matter (Rivkin, Yin, 2011;Kane, Weber, Dasta, 2003;Moura et al, 2012;Papadopoulos, Smithburger, 2010;Mannheimer, Eliasson, 2010.;Moreira, Cassiani, 2011).…”

Section: Introductionmentioning

confidence: 91%

“…A recent study conducted in the USA showed that 46.3% of ICU prescriptions included pDDIs (Smithburger, Kane-Gill, Seybert, 2012), while Brazilian studies have reported a prevalence of 67% or 70% (Hammes et al, 2008;Moreira, Cassiani, 2011). In addition, there are international differences in drug availability that may contribute to regional variations in the number of pDDIs (Moreira, Cassiani, 2011;Moura, Prado, Acurcio, 2011;Moura et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of potential drug-drug interactions in the intensive care unit of a Brazilian teaching hospital

Rodrigues

Stahlschmidt

Granja

et al. 2017

Braz. J. Pharm. Sci.

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Patients in intensive care unit are prescribed large numbers of drugs, highlighting the need to study potential Drug-Drug Interactions in this environment. The aim of this study was to delineate the prevalence and risk of potential drug-drug interactions between medications administered to patients in an ICU. This cross-sectional observational study was conducted during 12 months, in an adult ICU of a teaching hospital. Inclusion criteria were: prescriptions with 2 or more drugs of patients admitted to the ICU for > 24 hours and age of ≥18 years. Potential Drug-Drug Interactions were quantified and classified through Micromedex TM database. The 369 prescriptions included in this study had 205 different drugs, with an average of 13.04 ± 4.26 (mean ± standard deviation) drugs per prescription. Potential Drug-Drug Interactions were identified in 89% of these, with an average of 5.00 ± 5.06 interactions per prescription. Of the 405 different pairs of potentially interacting drugs identified, moderate and major interactions were present in 74% and 67% of prescriptions, respectively. The most prevalent interaction was between dipyrone and enoxaparin (35.8%), though its clinical occurrence was not observed in this study. The number of potential Drug-Drug Interactions showed significant positive correlations with the length of stay in the intensive care unit, and with the number of prescribed drugs. Acknowledging the high potential for Drug-Drug Interactions in the ICU represents an important step toward improving patient safety and best therapy results.Uniterms: Potential drug-drug interactions. Intensive care unit. Patient safety. University hospitals.

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Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Prevalence of potential drug-drug interactions in the intensive care unit of a Brazilian teaching hospital

Rodrigues

Stahlschmidt

Granja

et al. 2017

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

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“…The committee set up 22 meetings during the study period, attended by a median of 7 professionals [IQR, [6][7][8][9] per meeting. This included a median of 3 pharmacists [IQR, [3][4] for a median of 1.5 technicians [IQR, 1-2] per meeting.…”

Section: Resultsmentioning

confidence: 99%

“…Each part of the medication process (prescription, transcription, dispensing, administration and monitoring) has been targeted in order to prevent ADEs and potential ADEs and thus improve patient safety. To address each part of the process, several methods have been suggested and carried out such as computerized prescriber order entry (CPOE), decision support with CPOE and clinical pharmacists (for the prescription and transcription parts), bar code technology and automated dispensing cabinets (ADCs) (for the dispensing part) [6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

An Experience Feedback Committee for Improving Medication Process Safety: An Observational Study in a Hospital Pharmacy Department

Caporossi¹,

Brudieu²,

Lehmann³

et al. 2014

J Pharma Care Health Sys

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Study objective: An experience feedback committee (EFC) is a management method for patient safety designed for a medical team. The aim of this study was to analyse the functioning of an EFC in a hospital pharmacy department and to explore its contribution to medication process safety. Design:We conducted a transversal, observational study based on the analysis of all the written documents produced by the EFC between January 2012 and December 2013. Setting:The study was conducted in the pharmacy department at Grenoble University Hospital in France. Measurements:We analysed all the documents related to incidents reported, the reports of meetings and the reports of event analysis. Patient outcomes (degree of harm) were assessed according to the Conceptual Framework for the International Classification for Patient Safety. The main outcome was the corrective actions decided by the EFC.Main Results: During the study period, there were 22 meetings attended by a total of 59 professionals including seven pharmacists. A total of 320 incidents were analysed. Most of them (92%) had no medical consequence for the patient. Twenty-two incidents were selected to be thoroughly analysed. One hundred and ten corrective actions were carried out including 32 training sessions, 32 guidelines written, 32 changes in organisation, nine changes in equipment and five changes in another category. Conclusions:The EFC is an attractive method to involve healthcare professionals in quality and safety management.

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“…IM-Pharma, another electronic screening system to detect drug-drug interactions, also was shown to reduce the occurrence of inappropriate prescriptions with drug-drug interactions. 20 InterMED-Rx is a software program designed to identify CYP450 drug-drug interactions; its implementation was reported to identify elderly patients at risk for drug-drug interactions. 21 …”

Section: What Should Clinicians and Researchers Do?mentioning

confidence: 99%

Drug-Drug Interactions and Acute Kidney Injury: Caveat Prescriptor

Mendu

Waikar

2014

American Journal of Kidney Diseases

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Evaluation of drug–drug interaction screening software combined with pharmacist intervention

Abstract: The performance of IM-Pharma combined with pharmacist intervention was positive with an expressive reduction in the risk of DDIs.

Cited by 35 publications

References 28 publications

Prevalence of potential drug-drug interactions in the intensive care unit of a Brazilian teaching hospital

Prevalence of potential drug-drug interactions in the intensive care unit of a Brazilian teaching hospital

An Experience Feedback Committee for Improving Medication Process Safety: An Observational Study in a Hospital Pharmacy Department

Drug-Drug Interactions and Acute Kidney Injury: Caveat Prescriptor

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