Abstract:A learning curve characterized by an increase in the D90post can be observed and results in a stable technique after 18 patients. An important factor influencing the learning curve in addition to the precision of seed positioning is organ volume definition on postimplant imaging.
“…Using TPSI, besides the experience of the implanting team an optimal treatment technique in TPSI is essential [13]. Grimm et al [10] implanted 125 patients between 1988 and 1990 and reported a follow-up of 10 years (Figure 3).…”
In low-risk prostate cancer patients, TPSI with intraoperative ultrasound-based treatment planning and fluoroscopy leads to excellent local tumor control and PSA relapse-free survival.
“…Using TPSI, besides the experience of the implanting team an optimal treatment technique in TPSI is essential [13]. Grimm et al [10] implanted 125 patients between 1988 and 1990 and reported a follow-up of 10 years (Figure 3).…”
In low-risk prostate cancer patients, TPSI with intraoperative ultrasound-based treatment planning and fluoroscopy leads to excellent local tumor control and PSA relapse-free survival.
“…Permanent interstitial brachytherapy with 125 I or 103 Pd seed implants is a common treatment for early-stage prostate cancer [7,10,11,16]. Computed tomography-(CT-)based dosimetry is currently recommended as the standard for postimplant dosimetry [1,8,12,13].…”
With a decreasing edema of the prostate, an increasing dose both to the prostate and the anterior rectal wall resulted--the postimplant interval is essential for the dosimetry report. Due to a larger edema, a higher prescription dose might be needed for optimal cancer control in smaller prostates. Compared to day 1, the dose to the surrounding tissues increased on day 30, particularly at the posterior and inferior prostate borders.
“…Current options for the treatment of organ-confined prostate cancer include radical surgery, photon-based external-beam therapy, brachytherapy or special treatment options such as proton radiotherapy [2,8,12,15,18,20,21,28,30,38].…”
IMRT enabled dose reductions to OARs in the medium dose range compared to 3-D conformal radiotherapy. A rather simple two-field proton-based treatment technique further reduced doses to OARs compared to photon-beam radiotherapy. The advantageous dose distribution of proton-beam therapy for prostate cancer may result in reduced side effects, which needs to be confirmed in clinical studies.
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