Evaluation of dogs as sentinels of the transmission of<i>Trypanosoma cruzi</i>in a rural area of north-western Argentina

Castañera, Mónica B.; Lauricella, Marta A.; Chuit, Roberto; Gürtler, Ricardo E.

doi:10.1080/00034983.1998.11813327

Cited by 76 publications

(80 citation statements)

References 14 publications

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“…These low infection rates in both the domiciliary and peridomestic sites were likely associated with low T. infestans densities and low rates of domiciliary recolonization as a consequence of selective deltamethrin sprays in the study villages combined with massive sprays in the province of Santiago del Estero. These interventions brought about a steady, very similar decline in the prevalence of dogs seropositive for T. cruzi in all five villages, from 65% in 1992 to 39% in 1994 and 15% in 1996 (18). Moreover, no autochthonous cases of seroconversion for T. cruzi were detected among local children (unpublished results).…”

Section: Discussionmentioning

confidence: 90%

“…However, the two infected T. guasayana found were nymphs from peridomes- cruzi, 2) frequent invasion of domiciliary areas and attacks on humans and dogs, and 3) its significant association with young native dogs seropositive for T. cruzi born during the surveillance period (18). More data are needed to assess the actual infection rates of T. guasayana, using enhanced detection procedures and carefully designed sampling programs.…”

Section: Discussionmentioning

confidence: 99%

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Trypanosoma cruzi infection in Triatoma infestans and other triatomines: long-term effects of a control program in rural northwestern Argentina

Cecere¹,

Castañera²,

Canale³

et al. 1999

Rev Panam Salud Publica

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Trypanosoma cruzi infection in Triatoma infestans and other triatomines: long-term effects of a control program in rural northwestern Argentina

Cecere¹,

Castañera²,

Canale³

et al. 1999

Rev Panam Salud Publica

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“…Los valores de prevalencia en caninos observados en este trabajo confirman los datos obtenidos por Rojas et al 9 en la parroquia de Xaguas (municipio Urdaneta), quienes reportaron una prevalencia del 6,4%. Cuando la incidencia en humanos es baja, el perro por sus hábitos biológicos y conductuales actúa como indicador o centinela de la existencia de transmisión activa de la enfermedad en las áreas controladas 14 .…”

Section: Discussionunclassified

Seroprevalencia de la infección por Trypanosoma cruzi y factores asociados en un área endémica de Venezuela

et al. 2011

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Determinamos factores de riesgo asociados a la seropositividad para anticuerpos anti-Trypanosoma cruzi en 26 poblaciones rurales, 905 viviendas, 2.156 individuos y 333 caninos en el Estado Lara, Venezuela. La seropositividad fue determinada mediante ELISA y MABA. Los datos fueron obtenidos mediante encuestas entomológicas, demográficas y médicas. Los factores de riesgo fueron establecidos mediante regresión logística binaria. La seroprevalencia humana fue de 7,24% y la canina 6,9%. La seropositividad estuvo asociada positivamente al Rhodnius prolixus, la edad, madre con antecedentes de Chagas, consumo de chimó, presencia de mamíferos y aves en la vivienda, desorden en el domicilio, y anexos de bajareque, nidos y cuevas en el peridomicilio. Negativamente con hábitos de consumo de tabaco y alcohol, antecedentes de cáncer y a depósitos en el peridomicilio. En conclusión, la enfermedad de Chagas en el área rural estudiada es un fenómeno remoto transmitida por R. prolixus y vía transplacentaria, asociada a hábitos socioculturales relacionados con la pobreza, a entornos selváticos y antecedentes médicos del huésped.

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“…Further, serological evidence of T. cruzi infection was found in 6 (2.5%) of 237 residents and in 6 (60%) of 10 dogs from the vicinity of the patient in California (36), and the case in Tennessee was associated with serological evidence of T. cruzi infection in a domestic canine owned by the patient's family, as well as the finding of an infected reduviid insect within the household (23). Dogs are considered important reservoirs for the transmission of T. cruzi in Latin American countries and in some areas of the United States (7,20,21,35,43) and serve as natural surveillance sentinels in areas of Latin America where vector control campaigns have been conducted (14,22).…”

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confidence: 99%

Combined Use of Enzyme-Linked Immunosorbent Assay and Flow Cytometry To Detect Antibodies toTrypanosoma cruziin Domestic Canines in Texas

Shadomy

Waring

Chappell

2004

Clin Vaccine Immunol

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Canines may be sentinels and/or reservoirs for human Trypanosoma cruzi exposures. This study adapted a method originally designed for human diagnostics to detect serum immunoglobulin G to T. cruzi in canines. The method combined an enzyme-linked immunosorbent assay (ELISA) for screening and flow cytometry detection of anti-live trypomastigote antibodies (ALTA) for confirmation. The assays were optimized by using known positive and negative control canine sera, and cutoff values were established. The ELISA and ALTA assay easily distinguished between reactive (positive controls) and nonreactive (negative controls) sera and were used to test sera collected in a cross-sectional seroprevalence survey of 356 domestic canines from Harris County, Tex., and the surrounding area. Fifty-three (14.9%) of 356 asymptomatic canines in the survey were positive by ELISA, and 5 (1.4%) were confirmed positive with the ALTA assay, with an additional 4 (1.1%) canines classified as "suspect positive." Thus, the overall prevalence of T. cruzi antibodies in this population was 2.6%. This is the first U.S. study to use the combination of ELISA and ALTA to detect serum antibodies to T. cruzi and the first report of the prevalence of T. cruzi infection in domestic canines in the Houston, Tex. (Harris County), region. Our results demonstrate that the combination of ELISA and ALTA has been successfully adapted for use in testing canines for serological evidence of T. cruzi infection. Seroprevalence survey results suggest that T. cruzi antibody-positive domestic canines in the peridomestic setting are present in the Houston, Tex., region and further suggest that T. cruzi is enzootic in the region.

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Evaluation of dogs as sentinels of the transmission ofTrypanosoma cruziin a rural area of north-western Argentina

Cited by 76 publications

References 14 publications

Trypanosoma cruzi infection in Triatoma infestans and other triatomines: long-term effects of a control program in rural northwestern Argentina

Trypanosoma cruzi infection in Triatoma infestans and other triatomines: long-term effects of a control program in rural northwestern Argentina

Seroprevalencia de la infección por Trypanosoma cruzi y factores asociados en un área endémica de Venezuela

Combined Use of Enzyme-Linked Immunosorbent Assay and Flow Cytometry To Detect Antibodies toTrypanosoma cruziin Domestic Canines in Texas

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