Evaluation of DNA repair capacity in parents of pediatric patients diagnosed with autism spectrum disorder using the comet assay procedure

Akouchekian, Mansoureh; Alizadeh, Rasoul; Beiranvandi, Fatemeh; Dehghan Manshadi, Masoumeh; Taherizadeh, Fatemeh; Hakim Shooshtari, Mitra

doi:10.1016/j.ibneur.2023.10.003

IBRO Neuroscience Reports

2023

DOI: 10.1016/j.ibneur.2023.10.003

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Evaluation of DNA repair capacity in parents of pediatric patients diagnosed with autism spectrum disorder using the comet assay procedure

Mansoureh Akouchekian,

Rasoul Alizadeh,

Fatemeh Beiranvandi

et al.

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2024

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Introducing the Role of Genotoxicity in Neurodegenerative Diseases and Neuropsychiatric Disorders

Kisby,

Wilson,

Spencer

2024

IJMS

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Decades of research have identified genetic and environmental factors involved in age-related neurodegenerative diseases and, to a lesser extent, neuropsychiatric disorders. Genomic instability, i.e., the loss of genome integrity, is a common feature among both neurodegenerative (mayo-trophic lateral sclerosis, Parkinson’s disease, Alzheimer’s disease) and psychiatric (schizophrenia, autism, bipolar depression) disorders. Genomic instability is associated with the accumulation of persistent DNA damage and the activation of DNA damage response (DDR) pathways, as well as pathologic neuronal cell loss or senescence. Typically, DDR signaling ensures that genomic and proteomic homeostasis are maintained in both dividing cells, including neural progenitors, and post-mitotic neurons. However, dysregulation of these protective responses, in part due to aging or environmental insults, contributes to the progressive development of neurodegenerative and/or psychiatric disorders. In this Special Issue, we introduce and highlight the overlap between neurodegenerative diseases and neuropsychiatric disorders, as well as the emerging clinical, genomic, and molecular evidence for the contributions of DNA damage and aberrant DNA repair. Our goal is to illuminate the importance of this subject to uncover possible treatment and prevention strategies for relevant devastating brain diseases.

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Introducing the Role of Genotoxicity in Neurodegenerative Diseases and Neuropsychiatric Disorders

Kisby,

Wilson,

Spencer

2024

IJMS

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Evaluation of DNA repair capacity in parents of pediatric patients diagnosed with autism spectrum disorder using the comet assay procedure

Cited by 1 publication

References 31 publications

Introducing the Role of Genotoxicity in Neurodegenerative Diseases and Neuropsychiatric Disorders

Introducing the Role of Genotoxicity in Neurodegenerative Diseases and Neuropsychiatric Disorders

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