Evaluation of DNA-mediated electron transfer using a hole-trapping nucleobase under crowded conditions

Taketomi, Yuuki; Yamaguchi, Yuuki; Sakurai, Shunsuke; Tanaka, Masataka

doi:10.1039/d1ob01669e

Cited by 1 publication

(4 citation statements)

References 38 publications

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“…The CD spectra of the solutions containing these DNA condensates are shown in Figure 2. The extremely strong CD sign of the bands (inset of Figure 2) showed the helical packing of dsDNAs in the cholesteric liquid crystalline DNA formed without heating [10,25] . The CD spectral measurements of the solution containing the hexagonal DNA assemblies showed the disappearance of the extremely strong CD sign, indicating the untwisted state of DNA assemblies in the hexagon.…”

Section: Resultsmentioning

confidence: 99%

“…The extremely strong CD sign of the bands (inset of Figure 2) showed the helical packing of dsDNAs in the cholesteric liquid crystalline DNA formed without heating. [10,25] The CD spectral measurements of the solution containing the hexagonal DNA assemblies showed the disappearance of the extremely strong CD sign, indicating the untwisted state of DNA assemblies in the hexagon. Note that the procedure of heating and subsequent cooling of bluntended ds DNA resulted in different assemblies (Figure S1a in the Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

“…Micro‐sized hexagonal DNA platelets also have great potential in materials science and biomedical applications, such as for biomedicines and drug delivery. For example, from the viewpoint of application to materials, the electrical conductivity of dsDNA has been investigated for decades [25,28] . Hexagonal DNA platelets may also exhibit unique electrical conductivity.…”

Section: Discussionmentioning

confidence: 99%

“…For example, from the viewpoint of application to materials, the electrical conductivity of dsDNA has been investigated for decades. [25,28] Hexagonal DNA platelets may also exhibit unique electrical conductivity. Investigations of these characteristics, as well as further investigations on the hexagonal formation, are underway in our laboratory.…”

Section: Discussionmentioning

confidence: 99%

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Self‐Assembled Micro‐Sized Hexagons Built from Short DNA in a Crowded Environment

2022

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DNA programmable structures of various morphologies have attracted extensive attention due to their potential for materials science and biomedical applications. Here, we report the formation of micro‐sized hexagons via assembly of only one pair of short double‐stranded DNA in buffer‐salt poly(ethylene glycol) solution. Each DNA strand had complementary bases with a two‐base overhang. The procedure of heating and subsequent cooling of blunt‐ended double‐stranded DNA resulted in different assemblies. These results indicated that end‐to‐end adhesion at the terminals induced by complementary overhangs were required to construct the hexagonal DNA assemblies. The stable formation of the hexagons was highly dependent on heating temperature. In addition, concentration adjustments of DNA and poly(ethylene glycol) were essential. Circular dichroism spectral measurements and polarization microscopy observations indicated parallel alignment of double‐stranded DNA in the hexagonal platelet. Self‐assembled micro‐sized hexagons composed of simple building blocks may have great potential for future biomedical device development.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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