Evaluation of Diuretic Effect of the Hot Water Extract of Standardized Tragia involucrata Linn., in Rats

Pallie, M. S.; Perera, Pathirage Kamal; Goonasekara, Charitha L.; Kumarasinghe, K. M. N.; Arawwawala, L.D.A.M.

doi:10.3923/ijp.2017.83.90

Cited by 6 publications

(6 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, both the EAF and CF caused increment of urinary Na + , K + , and Cl − excretion with significant alkalization of urine. As a result, the diuretic activity of the EAF and CF may be different from loop-like diuretics because loop diuretics cause marked natriuresis and urine acidification [ 16 ]. It is reasonable to suggest that the constituent(s) present in the root bark of C. myricoides seems to have different diuretic mechanisms of action.…”

Section: Discussionmentioning

confidence: 99%

“…The widespread use of the medicinal plant by local people entails the necessity of testing of their efficacy and safety profile [ 16 ]. Therefore, this study aimed to investigate the effect of both the hydromethanolic extract and different solvent fractions of the root bark of C. myricoides on the urine output, urine pH, and both urine and serum electrolytes of rats.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In Vivo Diuretic Activity of Hydromethanolic Extract and Solvent Fractions of the Root Bark of Clerodendrum myricoides Hochst. (Lamiaceae)

Welu

Yimer

Hailu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Introduction. Clerodendrum myricoides (Lamiaceae) has been traditionally used for the treatment of various ailments, including body swelling and urine retention. The present study aimed to evaluate the diuretic activity of a crude extract and solvent fractions of the root bark of C. myricoides. Methodology. The coarsely powdered root bark of C. myricoides was extracted by a cold maceration method using 80% methanol. A portion of the extract was fractionated based on the polarity index of solvents to obtain chloroform, ethyl acetate, and aqueous fractions. To investigate the diuretic activity of the plant, rats were divided into fifteen groups. The normal control groups received either water or 2% tween 80, the standard group received furosemide (10 mg/kg), and the test groups were administered the hydromethanolic extract and solvent fractions at the doses of 100, 200, and 400 mg/kg by the oral route. The urine volume, urine pH, urine, and serum electrolytes were determined and compared with the standard and normal control groups. Results. The crude hydromethanolic extract, ethyl acetate, and chloroform fractions induced significant diuresis at a dose of 400 mg/kg ( P < 0.001 ) compared to the aqueous fraction. The hydromethanolic extract at 200 mg/kg and 400 mg/kg also caused noticeable diuresis ( P < 0.001 ) compared to the standard, furosemide. Rats treated with hydromethanolic extract, ethyl acetate, and chloroform fractions showed delayed onset and prolonged diuresis in a dose-dependent fashion compared to the aqueous fraction ( P < 0.05 ). The hydromethanolic extract and solvent fractions produced the highest saliuretic and natriuretic index compared to the standard, furosemide. The crude hydromethanolic extract also failed to produce any sign of toxicity up to 2000 mg/kg. Conclusion. From this study, the hydromethanolic extract and ethyl acetate fraction of the root bark of C. myricoides produced a prominent diuretic effect in rats.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In Vivo Diuretic Activity of Hydromethanolic Extract and Solvent Fractions of the Root Bark of Clerodendrum myricoides Hochst. (Lamiaceae)

Welu

Yimer

Hailu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…In agreement, the ethanol leaf extract of TI at dose 250 and 500 mg/kg showed potent nephroprotective activity against acetaminophen-induced toxicity in male albino rats on a study performed by Palani et al [ 104 ]. Its diuretic action was also studied by Pallie et al [ 67 ], which showed dose-dependent diuretic activity of the TI decoction on healthy rats at 550, 1100, 1650, and 2200 mg/kg. The therapeutic rat dose of this TI decoction was 550 mg/kg.…”

Section: Correlation Between the Biological Activities And The Ethmentioning

confidence: 94%

“…The tests were carried out using healthy Wistar rats. The results showed that the activity of the aqueous root extract and the decoction of the whole plant was most potent as a diuretic, and other extracts such as petroleum ether and chloroform extracts had mild activities [ 67 , 87 ].…”

Section: Biological Activities and Phytochemicals Found In mentioning

confidence: 99%

See 1 more Smart Citation

Ethnopharmacological Use and Biological Activities of Tragia involucrata L.

Pallie

Perera

Kumarasinghe

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Plants have been utilized as medicines to treat various ailments since ancient times. Formulations made by plant materials have been used in traditional, complementary, and alternative medicine and remain widespread in both developing and developed countries. In developing countries, traditional medicines are widely practiced due to its accessibility and affordability, while in developed countries, complementary and alternative medicine are widely popular due to the adverse effects of chemical drugs. Tragia involucrata Linn. (family: Euphorbiaceae) is a highly used medicinal plant used in both Sri Lankan and Indian traditional medical systems. Since this plant is a weed, it is being extensively destroyed due to the lack of knowledge regarding the medicinal value of this plant. Hence, the objective of this study was to collect data on the medicinal value of this plant by correlating its scientifically validated biological activities with its ethnopharmacological uses. An attempt was made to gather as much information available regarding the ethnopharmacological uses and scientifically validated biological activities of Tragia involucrata through authentic traditional texts, scientific journals, and other authentic texts regarding medicinal plants. Thus, the review provides an insight to the capability of Tragia involucrata to be used as a monoherbal formulation for diseases pertaining to multiple systems of the body. With all the scientifically validated biological activities and the ethnopharmacological uses, Tragia involucrata may qualify as a potent candidate to be developed into a phytomedicine to be utilized as both a preventive and as a therapeutic agent.

show abstract

Inhibition behavior of Tragia involucrata L. phenolic compounds against acidic medium corrosion in low carbon steel surface

Chung

Kim

Hemapriya³

et al. 2019

Chinese Journal of Chemical Engineering

View full text Add to dashboard Cite

Evaluation of Diuretic Effect of the Hot Water Extract of Standardized Tragia involucrata Linn., in Rats

Cited by 6 publications

References 22 publications

In Vivo Diuretic Activity of Hydromethanolic Extract and Solvent Fractions of the Root Bark of Clerodendrum myricoides Hochst. (Lamiaceae)

In Vivo Diuretic Activity of Hydromethanolic Extract and Solvent Fractions of the Root Bark of Clerodendrum myricoides Hochst. (Lamiaceae)

Ethnopharmacological Use and Biological Activities of Tragia involucrata L.

Inhibition behavior of Tragia involucrata L. phenolic compounds against acidic medium corrosion in low carbon steel surface

Contact Info

Product

Resources

About