Evaluation of Diuretic Activity of Aqueous Extract of Ripe Fruit Pulp of Tamarindus indica L. in Rats

Abstract

Introduction: Diuresis is an important pharmacological property which is useful in many clinical conditions. There is a need of better diuretics with lesser adverse effects in comparison to currently available diuretics. The study aimed to evaluate the diuretic activity of aqueous extract of fruit pulp of Tamarindus indica L. in rats.Methods: The study was undertaken with aqueous extract of fruit pulp of Tamarindus indica in three doses: 300 mg/kg, 600 mg/kg and1200 mg/kg for its diuretic activity in comparison with standard (furosemide) and vehicle control (normal saline) in Wistar rats. Urine volume and electrolytes were measured after 24 hours of drug administration.Results: Aqueous extract of fruit pulp of Tamarindus indica at the dose of 1200 mg/kg exhibited significant diuretic activity (p<0.05) without significant natriuretic effect. Magnesium excretion was also significantly increased in comparison to control group.Conclusion: Aqueous extract of fruit pulp of Tamarindus indica has significant diuretic activity in Wistar rats.

Antioxidant Potentials and Environmental Application of Tamarindus Indica Plant: A Brief Narrative Review

“…Tamarindus indica L. is a perennial evergreen tree belong to the family Fabaceae or Leguminosae, subfamily Caesalpinioideae. It is cultivated worldwide, naturalized partly in the tropics and subtropics [1] [2]. Two types of tamarind includes the 'sour' which is the most common and 'sweet' found mostly in Thailand, both can be eaten fresh (unripe/ripe) or as a processed product [3] [4].…”

“…Different parts of this plants viz. pulp, fruits, seeds, leaves, flowers and bark have been used in traditional medicine for various clinical conditions [1][5] [9]. Research without number were documented on nutritive value of several part of this plant with high carbohydrate, protein, fat and minerals content [6][7] [10][11] [12].…”