Abstract:Distal symmetric polyneuropathy (DSP) is the most common variety of neuropathy. Since the evaluation of this disorder is not standardized, the available literature was reviewed to provide evidence-based guidelines regarding the role of autonomic testing, nerve biopsy, and skin biopsy for the assessment of polyneuropathy. A literature review using MEDLINE, EMBASE, Science Citation Index, and Current Contents was performed to identify the best evidence regarding the evaluation of polyneuropathy published between… Show more
“…The most reliable test is the skin biopsy that objectively measures the intraepidermal nerve fiber density. This is a simple outpatient procedure which, when standardized, can accurately diagnose SFN [48,49]. Sural nerve biopsy is not useful and is not recommended.…”
“…The most reliable test is the skin biopsy that objectively measures the intraepidermal nerve fiber density. This is a simple outpatient procedure which, when standardized, can accurately diagnose SFN [48,49]. Sural nerve biopsy is not useful and is not recommended.…”
“…These techniques are also helping us to look more closely at the pathophysiology of neurotoxicity and point us in the direction of better treatments [25]. Another interesting assessment method for CIN is skin biopsy [26][27][28][29]. It allows the unmyelinated small nervous fi bres that lie in the epidermis to be seen and quantifi ed in vivo.…”
Chemotherapy-induced peripheral neuropathy (CIN) is a common toxicity of anticancer treatment and its incidence is growing. It significantly affects quality of life and is a dose-limiting factor that interferes with treatment. Its diagnosis can be established in clinical terms but some complementary tests can help when the diagnosis is difficult. There is still no proven method to prevent it that has become a standard of care in spite of the huge amount of investigation carried out in recent years. There are promising strategies that could help reduce the burden of this complication. This review will suggest an approach to the diagnosis of these disorders and provide an update on new therapies.
“…El mecanismo de esta SCP no es del todo claro pero podría corresponder a una sensibilización de nociceptores 18 o a la expresión de aferentes sensibles al frío y mentol con pérdida de los aferentes A delta 11 . Otros métodos diagnósticos de neuropatía de fibras delgadas como los estudios de función autonómica y la biopsia cutánea con cuantificación de la densidad de fibras epidérmi-cas son complementarios y han sido validadas en múltiples estudios 14,19 . La microneurografía, desarrollada en Suecia y Alemania a fines de la década 1960-69, es una herramienta de mucho valor en la comprensión de la función de aferentes delgados en sujetos normales 5 , así como en la detección de anomalías funcionales en pacientes con neuropatía dolorosa [20][21][22] .…”
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