Evaluation of Diminished Microbial Contamination in Handling of a Novel Daily Disposable Flat Pack Contact Lens

Nomachi, Miya; Sakanishi, Kotaro; Ichijima, Hideji; Cavanagh, Harrison D

doi:10.1097/icl.0b013e31828c0abe

Cited by 10 publications

(7 citation statements)

References 9 publications

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“…The lens can easily be manipulated onto a clean finger and applied to the eye with high confidence that the inner surface that comes into contact with the cornea has not been contaminated. Simulated tests of bacterial adherence using 3− 5 μm PMMA beads or bacterial adherence of S. aureus to lenses removed from the flat pack compared to lenses removed from more conventional blister packages found contamination was reduced on the flat pack lenses [501]. This has particular relevance for single use lenses, as contaminated fingers are likely to be the main route of transferring bacteria to the eye using this wearing modality.…”

Section: Contact Lens Packagingmentioning

confidence: 99%

BCLA CLEAR – Contact lens technologies of the future

Jones

Hui

Phan

et al. 2021

Contact Lens and Anterior Eye

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Contact lenses in the future will likely have functions other than correction of refractive error. Lenses designed to control the development of myopia are already commercially available. Contact lenses as drug delivery devices and powered through advancements in nanotechnology will open up further opportunities for unique uses of contact lenses.This review examines the use, or potential use, of contact lenses aside from their role to correct refractive error. Contact lenses can be used to detect systemic and ocular surface diseases, treat and manage various ocular conditions and as devices that can correct presbyopia, control the development of myopia or be used for augmented vision. There is also discussion of new developments in contact lens packaging and storage cases.The use of contact lenses as devices to detect systemic disease has mostly focussed on detecting changes to glucose levels in tears for monitoring diabetic control. Glucose can be detected using changes in colour, fluorescence or generation of electric signals by embedded sensors such as boronic acid, concanavalin A or glucose oxidase. Contact lenses that have gained regulatory approval can measure changes in intraocular pressure to monitor glaucoma by measuring small changes in corneal shape. Challenges include integrating sensors into contact lenses and detecting the signals generated. Various techniques are used to optimise uptake and release of the drugs to the ocular surface to treat diseases such as dry eye, glaucoma, infection and allergy. Contact lenses that either mechanically or electronically change their shape are being investigated for the management of presbyopia. Contact lenses that slow the development of myopia are based upon incorporating concentric rings of plus power, peripheral optical zone(s) with add power or non-monotonic variations in power. Various forms of these lenses have shown a reduction in myopia in clinical trials and are available in various markets.

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Section: Contact Lens Packagingmentioning

confidence: 99%

BCLA CLEAR – Contact lens technologies of the future

Jones

Hui

Phan

et al. 2021

Contact Lens and Anterior Eye

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“…Assuming that the equilibrium is achieved during the shelf-life, it would be important to minimize the volume of the packaging liquid to maximize the fraction of drug retained in the lens. The Miru contact lenses from Menocon are packaged in a flat blister pack that contains only 0.2 ml of liquid, a significant reduction in the storage liquid compared to traditional packaging, but still significantly larger than the contact lens volume [110]. In addition to the loss of drug to the fluid, potential destabilization of the drugs and/ or other components incorporated into the lenses such as lipids, surfactants, and so on, must also be considered.…”

Section: Expert Opinionmentioning

confidence: 99%

Therapeutic contact lenses: a patent review

Dixon

Shafor

Gause

et al. 2015

Expert Opinion on Therapeutic Patents

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Among all non-invasive alternatives, contact lenses offer the highest bioavailability to the cornea due to the location of the lens in the immediate vicinity of the cornea. Several approaches have been patented to improve contact lens design for an extended release duration of drugs. Many technologies have successfully integrated suitable drug release profiles into contact lenses, but drug-eluting contacts are not yet commercialized likely due to regulatory challenges, including the high costs of clinical trials.

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“…Now there is evidence to support that statement. Nomachi et al [53] described a study in which they evaluated the microbial contamination of handling a DD contact lens removed from a novel "flat pack" designed storage case. The flat pack storage container is approximately 1 mm thick and the lens is stored with its front surface "up" so that when the lens is removed from the case prior to insertion, only the front surface of the lens is touched thus protecting the posterior surface of the contact lens from contamination.…”

Section: Mitigating Strategies Of Microbial Contaminationmentioning

confidence: 99%