Evaluation of Diffusion-Weighted MR Imaging at Inclusion in an Active Surveillance Protocol for Low-Risk Prostate Cancer

Abstract

Median ADC is able to predict the presence and grade of PCa in CSRs identified by MP-MRI.

Novel Tools to Improve Patient Selection and Monitoring on Active Surveillance for Low-risk Prostate Cancer: A Systematic Review

“…The literature search identified 30 original articles that were included for review: 14 on magnetic resonance imaging (MRI) [8][9][10][11][12][13][14][15][16][17][18][19][20][21], 5 on serum markers [22][23][24][25][26], 5 on urinary markers [27][28][29][30][31], 4 on histopathology markers [32][33][34][35], and 2 on germline genetic markers [36,37]. Figure 1 presents the search strategy and study selection flowchart.…”

“…Somford et al performed 3-T MP-MRI with endorectal coil (including T2-weighted and DW images) in patients included in an AS protocol (n = 54) [20]. At least one suspicious region (two in most patients) was identified in 98% of patients and biopsied.…”

Multiparametric magnetic resonance imaging vs. standard care in men being evaluated for prostate cancer: A randomized study

“…The combination of anatomical and functional information provided by mp-MRI, compared with morphological imaging based on high-resolution T2w imaging only, makes it a promising successful imaging tool for improving the Se, Spe, and accuracy in PCa detection, as validated by the results in our study. The benefits of mp-MRI include early detection of PCa; depiction of tumors missed on biopsy; improved biopsy accuracy; reduction in the number of cores per biopsy; the exclusion of clinically significant disease to enroll patients in active surveillance; surgical, radiation treatment; and focal therapies planning and evaluation of response to therapies [4,[10][11][12][13][14]. Moreover, MR tractography by means of diffusion tensor imaging has shown promising results in the visualization and quantification of periprostatic nerve plexus of neuroanatomical fiber density.…”

Assessment of Prostate Cancer With Dynamic Contrast-Enhanced Computed Tomography Using an En Bloc Approach

“…The lack of contrast resolution makes it impossible to visually localize cancer on nonenhanced CT. 13,23 This challenged the centering of the perfusion volume in older studies at times when only z-axis coverage of less than 4 cm was available. 22,23,26,27 But even with today's 256-slice scanners that allow for a much larger z-axis (up to 28 cm), it is still almost impossible to localize prostate cancer on contrast-enhanced CT images in the absence of extracapsular spread.…”