Evaluation of Different Levels Thyroid Dysfunction in Patients having Diffuse Goiter from Rawalpindi and Islamabad

Ameen, Muhammad

doi:10.21767/2472-1158.100065

Cited by 2 publications

(2 citation statements)

References 7 publications

(7 reference statements)

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“…Such studies would be helpful to understand the prevalence of diffuse goitre in different subjects and will also suggest the measures to minimise the goitre associated with its onset. (24) CONCLUSION It can be concluded that multinodular goitre is the most common thyroid disease with a diverse aetiology. Multinodular thyroid disease is perhaps the commonest of all thyroid disorders in clinical practice worldwide.…”

Section: Discussionmentioning

confidence: 99%

A Clinical, Bio-Pathological Study of Multinodular Goitre in Rewa Region, Madhya Pradesh

Siddiqui¹,

Moupachi²,

Baghel³

2018

jemds

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BACKGROUND Multinodular goitre is the most prevalent thyroid gland biochemical change and pathology. Multinodular goitre is a condition with various clinical presentations. Although, the majority are benign, the incidence of occult malignancy in multinodular goitre varies from 1.2% to 16.66%. Accurate preoperative diagnosis of malignancy is therefore very important for appropriate management of the patient with multinodular goitre. MATERIALS AND METHODS This is a descriptive study of 23 patients attended in outpatient department and inpatient department with multinodular thyroid swelling from July 2015 to February 2016 at the Otorhinolaryngology Department, Gandhi Memorial and Sanjay Gandhi Memorial Hospitals, Shyam Shah Medical College, Rewa (MP). After registration of patients, a detailed history was taken and thorough clinical examination was carried out, which was entered in the proforma. All the patients underwent routine investigations, thyroid profile, x-ray and FNAC. Multinodular goitre specimen were sent for histopathological examination (HPE). 15 age and sex matched healthy control group were compared for thyroid profile. RESULTS 23 patients were selected for our descriptive study. Mean age for benign lesion was 39.5 years and for the malignant lesion was 33.5 years. Two peak incidences for malignant lesions were noted. Greater peaks for age groups are between 21-30 years with 50% of all cases of malignancy. Female-to-male ratio for malignancy was 0.8: 1. The average duration of symptom for malignancy was 2.46 years and for benign was 4.38 years. There was one false positive and one false negative FNAC result. Histopathology showed 8.69% patients had malignancy. Multinodular goitre (86.95%) was the most common diagnosis histopathologically among benign diseases. Papillary carcinoma was the most common malignant lesion. The overall sensitivity of fine needle aspiration cytology in multinodular goitre in our study was 80%. Thus, FNAC and thyroid profile are very good diagnostic tools preoperatively. CONCLUSION Multinodular goitre is the commonest thyroid disease in Rewa (MP), more common in males with chief complaints of symptomless swelling in front of the neck. The malignancy rates were slightly higher in males compared to females. 86.95% of the multinodular goitre were benign and 8.69% were malignant. Papillary carcinoma was the most common malignancy. FNAC and thyroid profile are a very good diagnostic tool for detection of multinodular goitre preoperatively.

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Section: Discussionmentioning

confidence: 99%

A Clinical, Bio-Pathological Study of Multinodular Goitre in Rewa Region, Madhya Pradesh

Siddiqui¹,

Moupachi²,

Baghel³

2018

jemds

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“…Thyroid hormones (THs) perform important functions, such as the regulation of nutrient metabolism, blood sugar, cholesterol, pregnancy and menstruation. 1,2 TH-associated abnormalities have been examined in approximately 110 countries, with 1.6 billion people identified to be at risk of developing thyroid disorders. 3,4 The prevalence of thyroid-related disorders varies significantly among men and women.…”

Section: Introductionmentioning

confidence: 99%

Hypothyroidism correlates with dyslipidemia and protein contents in patients with various metabolic disorders

et al. 2022

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Objectives The present study aimed to investigate the status of abnormalities in thyroid-related hormones, lipid profile parameters and total proteins in the sera of patients suffering from various metabolic disorders. Methods To analyze the study parameters, enzyme-linked immunosorbent assays, Bradford assays and standard clinical kits and methods were applied. Data were analyzed through the appropriate statistical tests. Results In all subjects except those with hypotension, thyroid-stimulating hormone, total cholesterol and low-density lipoprotein were elevated, whereas triiodothyronine levels were downregulated. Thyroxin was downregulated in subjects with diabetes and symptomatic thyroiditis but upregulated in patients with hypertension. High-density lipoprotein was upregulated in men who were diabetic only, and total protein was downregulated in those with hypotension only. Hypothyroidism in patients with diabetes, symptomatic thyroiditis and hypertension was correlated with dyslipidemia. In subjects with hypertension, it was correlated with total protein. Conclusion This study revealed a link between hypothyroidism, dyslipidemia and total protein in patients with various metabolic disorders.

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Evaluation of Different Levels Thyroid Dysfunction in Patients having Diffuse Goiter from Rawalpindi and Islamabad

Cited by 2 publications

References 7 publications

A Clinical, Bio-Pathological Study of Multinodular Goitre in Rewa Region, Madhya Pradesh

A Clinical, Bio-Pathological Study of Multinodular Goitre in Rewa Region, Madhya Pradesh

Hypothyroidism correlates with dyslipidemia and protein contents in patients with various metabolic disorders

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