Evaluation of diclofenac sodium incorporation in alginate membranes as potential drug release system

Optimization of the Green Extraction of Red Araçá (Psidium catteyanum Sabine) and Application in Alginate Membranes for Use as Dressings

“…These findings are consistent with those reported by Rhim et al [ 37 ], who developed cross-linked membranes by two methods (mixing film and immersion film) and obtained values ranging from 8.2 ± 2.2% to 3.4 ± 1.4% for cross-linked sodium alginate membranes in different concentrations of CaCl 2 solutions. In contrast, Pacheco et al [ 34 ] reported lower values than observed in the present study. The authors found values of 2.76 ± 1.33% for the control membrane and 1.94 ± 0.27% for the membrane incorporated with diclofenac sodium.…”

“…This behavior is also reported by Kharroubi et al [ 13 ], who developed gentamicin-loaded arabinoxylan-sodium alginate films for wound dressing using different formulations. The values obtained from ME and MC are close to the 0.108 mm for sodium alginate membrane obtained by the casting method performed by Pacheco et al [ 34 ]. Marangoni Junior et al [ 35 ] also reported similar thickness values of 0.131 and 0.144 mm for the control film of sodium alginate and films of sodium alginate with green propolis extract, respectively.…”

“…Kaczmarek [ 40 ] developed sodium alginate membranes with and without tannic acid and found values ranged from 0.0045 to 0.0067 g/m².s. Pacheco et al [ 34 ] also developed sodium alginate membranes incorporating diclofenac sodium (DS) with values of 0.0136 and 0.0272 g/m².s for sodium alginate membranes without DS and with DS, respectively. The results obtained in the present study suggest that the developed membranes are permeable to water vapor and capable of guaranteeing a humid environment at the wound site, avoiding excessive dehydration.…”

“…While the material itself may not exhibit porosity, alginate is highly hydrophilic, and following cross-linking and upon contact with the wound, it has the capability to form a gel, thereby facilitating the release of the enclosed compounds. Pacheco et al [ 34 ] observed a material with a uniform surface for cross-linked sodium alginate membranes without additives and membranes with greater roughness with the additive sodium diclofenac.…”

A review on orally disintegrating films (ODFs) made from natural polymers such as pullulan, maltodextrin, starch, and others

“…The proportion and distribution of these blocks depend on the alginate source and determine the biopolymer's properties. According to its properties, they can be used as films [85], membranes [86,87], hydrogels [88], microparticles [89], capsules for cells in the treatment of diabetes, among others [90][91][92][93].…”