Evaluation of diaphragmatic hernia repair using PLGA mesh–collagen sponge hybrid scaffold: an experimental study in a rat model

Abstract

Introduction: Patch closure is necessary to achieve tension-free repair in

Patch repair for congenital diaphragmatic hernia: is it really a problem?

“…In addition, pectus deformities and scoliosis have been attributed to use of a prosthetic patch [15], although no appropriate comparison of patients with CDH with large defects repaired without the use of a prosthetic patch has been published. The perception of patch failure and related morbidity has motivated the development of a variety of innovative alternatives to the use of a synthetic patch, including the use of biosynthetic materials [4,9,10], vascularized muscle flaps [11,12], and tissue engineering [13,14]. Although theoretically appealing, these approaches each have their own potential problems and in general represent more complex and expensive methods for closure of a simple anatomical defect.…”

“…The use of synthetic patches to close the hernia defect has been implicated as a significant contributor to ongoing morbidity with high rates of hernia recurrence and chest wall deformity reported [3][4][5][6][7][8][9][10]. In an attempt to avoid the use of prosthetic patches, considerable effort has been devoted to alternative means of diaphragmatic closure such as the use of vascularized muscle flaps [11,12], biosynthetic materials [4,9,10], and tissue engineering [13,14]. In contrast to the reported experience, our perception has been that we have had excellent results using synthetic patches in our population of severely affected patients with CDH.…”

A review of patch options in the repair of congenital diaphragm defects

“…This mesh was examined in a rat model at 1-, 2-and 3-month intervals for a left-sided diaphragmatic defect [27]. No recurrence was observed.…”

An eligible biological allograft patch in tension-free herniorrhaphy of swine

“…As the scaffold materials are degraded and absorbed, gradually new, regenerated tissue begins to replace the old and diseased tissue leading to functional improvement of the pathological tissue or organ (19). Materials for external abdominal hernia repair also belong to the category of scaffold material research areas (20).…”