Evaluation of dialdehydic anti-inflammatory active principles in extra-virgin olive oil by reactive paper spray mass spectrometry

Mazzotti, Fabio; Donna, Leonardo Di; Taverna, Domenico; Nardi, Mónica; Aiello, Donatella; Sindona, Giovanni

doi:10.1016/j.ijms.2013.07.012

Cited by 50 publications

(40 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The idea is similar to and inspired by reactive DESI [87][88][89][90][91][92][93]. Several papers describing reactive paper spray methods have been published, most of them dealing with derivatization of carbonyl groups [94][95][96]. In all of these cases, the motivation was primarily to increase the ionization efficiency (and therefore improve detection limits) of the targets.…”

Section: Challenges/limitationsmentioning

confidence: 99%

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

2016

View full text Add to dashboard Cite

Paper spray mass spectrometry (MS) is part of a cohort of ambient ionization or direct analysis methods that seek to analyze complex samples without prior sample preparation. Extraction and electrospray ionization occur directly from the paper substrate upon which a dried matrix spot is stored. Paper spray MS is capable of detecting drugs directly from dried blood, plasma, and urine spots at the low ng/mL to pg/mL levels without sample preparation. No front end separation is performed, so tandem mass spectrometry (MS/MS) or high resolution MS is required. Here, we discuss paper spray methodology, give a comprehensive literature review of the use of paper spray MS for bioanalysis, discuss technological advancements and variations on this technique, and discuss some of its limitations. _________________________________________________________________________________ AbstractPaper spray mass spectrometry (MS) is part of a cohort of ambient ionization or direct analysis methods that seek to analyze complex samples without prior sample preparation. Extraction and electrospray ionization occur directly from the paper substrate upon which a dried matrix spot is stored. Paper spray MS is capable of detecting drugs directly from dried blood, plasma, and urine spots at the low ng/mL to pg/mL levels without sample preparation. No front end separation is performed, so tandem mass spectrometry (MS/MS) or high resolution MS is required. Here, we discuss paper spray methodology, give a comprehensive literature review of the use of paper spray MS for bioanalysis, discuss technological advancements and variations on this technique, and discuss some of its limitations.

show abstract

Section: Challenges/limitationsmentioning

confidence: 99%

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

2016

View full text Add to dashboard Cite

show abstract

“…Soc. 826 a l b o m a c u l i n e ( 2 9 ) , 1 8 h a e m a n t h i d i n e ( 2 2 ) , 6 -e p i h a e m a n t h i d i n e ( 2 3 ) , 1 9 7 -m e t h o x y -Omethyllycorenine (12), 18 aulicine (15), 18 lycorine (25), 22,23 trisphaeridine (3), 21,24 galanthine (21), 20 and norpluviine (14), 25 were isolated and identified by comparison of their spectroscopic data with those previously reported. The phytochemical procedure was assisted by CGC-MS and the new compound haemanthamine N-oxide (1) was purified from a natural source for the first time.…”

Section: Figure 2 Alkaloids Identified In Hippeastrum Aulicummentioning

confidence: 99%

“…The PS-MS and LS-MS have been applied in chemical identification of natural products present in coffee, 12 fruits, 13 extra-virgin olive oils 14 and herbal teas. 15 Furthermore, LS-MS has also demonstrated excellent sensitivity for the direct identification of chemical species on the surface of leaves of plants such as Populus deltoids, Populus grandidentata, 11 Hibiscus moscheutos, Hibiscus syriacus 16 and Illicium anisatum.…”

Section: Introductionmentioning

confidence: 99%

Identification of Alkaloids from Hippeastrum aulicum (Ker Gawl.) Herb. (Amaryllidaceae) Using CGC-MS and Ambient Ionization Mass Spectrometry (PS‑MS and LS-MS)

Bessa

Andrade

Domingos

et al. 2016

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

Amaryllidaceae alkaloids are well-known isoquinolines which have demonstrated a wide range of biological activities such as antiviral, anticancer, acetylcholinesterase inhibition, antimalarial, among others. Mass spectrometry (MS) studies based on capillary gas chromatography (CGC), paper spray (PS), and leaf spray (LS) ionization were carried out for alkaloid investigation of the native Brazilian species Hippeastrum aulicum, along with nuclear magnetic resonance (NMR) techniques. Thirty-one alkaloids were identified including the new compound haemanthamine N-oxide. The results from PS-and LS-MS techniques were consistent with those observed in CGC-MS analysis. To the best of our knowledge, it is the first study combining NMR, CGC-MS and the ambient ionization-mass spectrometry (PS-and LS-MS) on Amaryllidaceae plants.

show abstract

“…Consequently, a considerable amount of these drugs is poured into the environment from many different sources. The problem becomes of public health concern, as well as environmental, starting from the moment these compounds enter into aquifers and foodstuffs [53,[66][67][68]. The method described so far was intended to enable us to draw conclusions about the presence of the 14 selected NSAIDs in the environment.…”

Section: Discussionmentioning

confidence: 99%

Occurrence of non-steroidal anti-inflammatory drugs in surface waters of Central Italy by liquid chromatography–tandem mass spectrometry

Rocca

Gentili

Caretti

et al. 2015

International Journal of Environmental Analytical Chemistry

View full text Add to dashboard Cite

Non-steroidal anti-inflammatory drugs (NSAIDs) are considered to be the cure-all of any pain: from headache and cold symptoms to toothaches and even labour pain. Their wide use in human medicine has been favoured by the possibility to purchase them without medical prescription, their low cost and by the absence of opioid-like side effects. At the same time, their administration to domestic and food-producing animals has become a common practice to improve their well-being. Therefore, human and veterinary applications are the main sources of NSAIDs in the environment and the major pathways are excretion and discharge through sewage treatment plants. Although their environmental occurrence is well-known, there is a lack of data regarding their levels in surface waters of Central Italy. In this study, a monitoring campaign was arranged in some of the most important rivers and lakes of Central Italy, characterised by a different anthropic impact, in spring-summer and autumn-winter 2012. A broad range of NSAIDs for human and animal use was analysed through a reliable analytical method based on liquid chromatography-tandem mass spectrometry, appropriately developed and validated. Results have shown the constant presence of all drugs commonly used in human medicine with a composition that mirrored the incidence of seasonal diseases quite well. A veterinary drug (flunixin) was found in Bracciano Lake (Rome district), an important tourist attraction surrounded by farmlands. Salicylic acid is a phytohormone and this explains its presence in all the analyzed samples. All the results collected during the extensive survey have proved that Central Italy is aligned with the rest of Europe since its natural waters have shown low levels of contamination (ngL(-1)) but with a chronic input

show abstract

Evaluation of dialdehydic anti-inflammatory active principles in extra-virgin olive oil by reactive paper spray mass spectrometry

Cited by 50 publications

References 31 publications

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

Identification of Alkaloids from Hippeastrum aulicum (Ker Gawl.) Herb. (Amaryllidaceae) Using CGC-MS and Ambient Ionization Mass Spectrometry (PS‑MS and LS-MS)

Occurrence of non-steroidal anti-inflammatory drugs in surface waters of Central Italy by liquid chromatography–tandem mass spectrometry

Contact Info

Product

Resources

About