Evaluation of Diagnostic and Therapeutic Approaches for Suspected Influenza A(H1N1)pdm09 Infection, 2009–2010

Vijayan, Vini; Jing, Jennie; Zangwill, Kenneth M.

doi:10.3201/eid1809.111564

Cited by 6 publications

(3 citation statements)

References 26 publications

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“…In the United States, there are few data describing clinician adherence to ACIP recommendations or the tendency for persons with influenza-like illness (ILI) to seek healthcare promptly after illness onset [1–3]. The few studies that have described adherence to ACIP treatment recommendations in an outpatient setting suggest that adherence could be improved [4, 5]. …”

Section: Introductionmentioning

confidence: 99%

Influenza-like Illness, the Time to Seek Healthcare, and Influenza Antiviral Receipt During the 2010–2011 Influenza Season—United States

Biggerstaff

Jhung

Reed

et al. 2014

The Journal of Infectious Diseases

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Background Few data exist describing health care seeking behaviors among persons with influenza-like illness (ILI) or adherence to influenza antiviral treatment recommendations. Methods We analyzed adult responses to the Behavioral Risk Factor Surveillance System in 31 states and the District of Columbia (D.C.) and pediatric responses in 25 states and D.C. for January – April 2011 by demographics and underlying health conditions. Results Among 75,088 adult and 15,649 child respondents, 8.9% and 33.9%, respectively, reported ILI. ILI was more frequent among adults with asthma (16%), chronic obstruction pulmonary disease (COPD; 26%), diabetes (12%), heart disease (19%), kidney disease (16%), or obesity (11%). Forty-five percent of adults and 57% of children sought health care for ILI. Thirty-five percent of adults sought care ≤2 days after ILI onset. Seeking care ≤2 days was more frequent among adults with COPD (48%) or heart disease (55%). Among adults with a self-reported physician diagnosis of influenza, 34% received treatment with antiviral medications. The only underlying health condition with a higher rate of treatment was diabetes (46%). Conclusion Adults with underlying health conditions were more likely to report ILI, but the majority did not seek care promptly, missing opportunities for early influenza antiviral treatment.

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Section: Introductionmentioning

confidence: 99%

Influenza-like Illness, the Time to Seek Healthcare, and Influenza Antiviral Receipt During the 2010–2011 Influenza Season—United States

Biggerstaff

Jhung

Reed

et al. 2014

The Journal of Infectious Diseases

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“…A retrospective cohort study in Los Angeles, California, described AV treatment practices at variance with CDC guidance for treatment of high-risk groups, but treatment among high-risk patients (94% of inpatients and 54% of outpatients) was more common than we observed. 14 The role of RIDTs in clinical decision-making during the pandemic was not explored in their analysis and has been seldom studied (for any epidemic).…”

Section: Discussionmentioning

confidence: 99%

Effect of Rapid Influenza Diagnostic Testing on Antiviral Treatment Decisions for Patients with Influenza-like Illness: Southwestern U.S., May–December 2009

et al. 2014

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Rapid influenza diagnostic tests (RIDTs) had low test sensitivity for detecting 2009 pandemic influenza A (H1N1pdm09) infection, causing public health authorities to recommend that treatment decisions be based primarily upon risk for influenza complications. We used multivariate Poisson regression analysis to estimate the contribution of RIDT results and risk for H1N1pdm09 complications to receipt of early antiviral (AV) treatment among 290 people with influenza-like illness (ILI) who received an RIDT ≤48 hours after symptom onset from May to December 2009 at four southwestern U.S. facilities. RIDT results had a stronger association with receipt of early AVs (rate ratio [RR] = 3.3, 95% confidence interval [CI] 2.4, 4.6) than did the presence of risk factors for H1N1pdm09 complications (age <5 years or high-risk medical conditions) (RR=1.9, 95% CI 1.3, 2.7). Few at-risk people (28/126, 22%) who had a negative RIDT received early AVs, suggesting the need for sustained efforts by public health to influence clinician practices.

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“…Currently, two classes (M2 channel blockers and neuraminidase inhibitors) of U.S. Food and Drug Administration (FDA)approved influenza antiviral drugs are available, but there are great concerns of emergence of viral resistance. Hence, timely identification of suitable targets, which are key elements related with the mechanism of the influenzas is crucial (Basler, 2007;Vijayan et al, 2012). Besides, the identification method should be used to predict targets for similar diseases in case of another flu *Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

Potential drug targets prediction for H1N1 influenza A based on protein-protein interaction networks

Chen¹,

Liu²,

Chen³

et al. 2012

Afr. J. Pharm. Pharmacol.

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In this paper, some proteins were determined as potential drug targets for H1N1 influenza A. These proteins were found using three steps: i) determining a set of human proteins that had interactions with the proteins of H1N1 virus, and assigning a weight to each protein; ii) mapping the set of human proteins into the human protein-protein interaction networks; iii) combining the topological properties of the network and the weights of the proteins to determine the score of each node. Eventually, TRAF2 and MAPK9, two nodes with high scores, were regarded as potential drug targets. The results were consistent when different databases were used, and were in agreement with the KEGG pathways to some degree. However, it still needs further study to ascertain whether these potential targets can be novel practical targets applied in the drug design.

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Evaluation of Diagnostic and Therapeutic Approaches for Suspected Influenza A(H1N1)pdm09 Infection, 2009–2010

Abstract: Variations between practice and national recommendations could inform clinical education in future influenza seasons.

Cited by 6 publications

References 26 publications

Influenza-like Illness, the Time to Seek Healthcare, and Influenza Antiviral Receipt During the 2010–2011 Influenza Season—United States

Influenza-like Illness, the Time to Seek Healthcare, and Influenza Antiviral Receipt During the 2010–2011 Influenza Season—United States

Effect of Rapid Influenza Diagnostic Testing on Antiviral Treatment Decisions for Patients with Influenza-like Illness: Southwestern U.S., May–December 2009

Potential drug targets prediction for H1N1 influenza A based on protein-protein interaction networks

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