Evaluation of demodicosis, nailfold capillaroscopy,
and oxidative stress in rosacea: a case-control study

Karabay, Ezgi Aktaş; Demirel, Ozlem Unay

doi:10.5114/ada.2021.108917

Cited by 5 publications

(5 citation statements)

References 34 publications

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“…The predominance of papulopustular type, higher number of patients and longer average disease duration in this study compared with our study may explain the difference in results. Similar to our study, in their study, which included 31 rosacea patients, Karabay et al detected no significant difference in TAS, TOS, and OSI levels between the rosacea and control groups 25 …”

Section: Discussionsupporting

confidence: 90%

“…Similar to our study, in their study, which included 31 rosacea patients, Karabay et al detected no significant difference in TAS, TOS, and OSI levels between the rosacea and control groups. 25 It is thought that there is a strong relationship between rosacea and systemic comorbidities. 26 It was associated with moderate and severe rosacea, hyperlipidemia, hypertension, CVDs, metabolic, and gastrointestinal diseases.…”

Section: Ta B L Ementioning

confidence: 99%

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Evaluation of serum TWEAK, TRAIL, and oxidative stress markers in rosacea patients

Durmaz

Türkmen

Altunışık

et al. 2022

J of Cosmetic Dermatology

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Background Rosacea is a chronic inflammatory skin disease of unknown pathogenesis. TWEAK and TRAIL are two cytokines thought to have a role in the pathogenesis of some inflammatory and autoimmune diseases. Aims The purpose of this study was to examine TWEAK and TRAIL serum levels and oxidative stress markers in patients with rosacea. Material and Method Forty rosacea patients and 40 sex‐ and age‐matched healthy controls were involved in the study. Serum TWEAK and TRAIL levels were evaluated with ELISA kits. Serum total antioxidant status, total oxidant status, total thiol, native thiol, disulfide levels were evaluated, and oxidative stress index was computed. Results Serum levels of TWEAK, TRAIL, and oxidative stress markers did not differ statistically in the patients and controls. Both TWEAK and TRAIL levels in the patients were detected to be statistically higher in male than in female. Conclusion TWEAK and TRAIL may not have a systemic effect in rosacea, unlike other inflammatory diseases. More studies are needed to investigate the role of TWEAK and TRAIL in rosacea.

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Section: Discussionsupporting

confidence: 90%

Section: Ta B L Ementioning

confidence: 99%

Evaluation of serum TWEAK, TRAIL, and oxidative stress markers in rosacea patients

Durmaz

Türkmen

Altunışık

et al. 2022

J of Cosmetic Dermatology

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“…The increase in the intensity of Demodex mites has begun to be accepted as an important trigger of the inflammatory cascade and a marker of rosacea. Also, rosacea papulopustules can be treated using acaricides [ 28 , 29 ]. We observed that the density of Demodex mites clearly increased in 80% of patients with rosacea.…”

Section: Discussionmentioning

confidence: 99%

Investigation of skincare habits and possible rosacea triggers of patients with rosacea: A prospective case–control study

Guder¹

2024

North Clin Istanbul

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OBJECTIVE Skincare is a part of rosacea treatment; patients benefit from complementary dermo-cosmetic care as well as medical treatments. Some skincare habits are known to trigger and exacerbate rosacea, but there are very few epidemiological studies on this matter. METHODS A total of 200 people, including 100 patients with rosacea and 100 controls, were included in the study. We questioned the methods used by the participants in daily facial cleansing. Sun and heat exposure, makeup habits, the history of the use of topical steroids, and outdoor working status were noted. A dermoscopic examination, a non-invasive and valuable method to evaluate the presence and severity of Demodex, was performed. RESULTS We evaluated 30% of our rosacea patients as erythematotelangiectatic rosacea, 13% as papulopustular rosacea, and 57% of our patients had mixed type, which could not be distinguished from one of these subtypes. In the case group, the proportion of people who used daily facial cleansers and daily soaps was lower than in the control group, while the proportion of those who cleaned their face with only water and those who used facial cleansers less frequently was higher (p<0.001). In the case group, while the rate of daily make-up and use of make-up products was lower (p=0.001, p<0.001, respectively), the rate of not wearing make-up was higher (p=0.001). The history of hot bath use was higher in the case group than in the control group (p=0.011). We found a significant relationship between the severity of plaque and dry appearance and the increase in Demodex density (p=0.007, p<0.001, respectively). CONCLUSION We recommend that patients with rosacea clean their faces daily with soap or facial cleansers and not take a bath with very hot water. Patients should be evaluated for increased Demodex mites, especially if skin dryness is accompanied.

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“…It should be noted that there is con icting evidence about the possible anti-in ammatory impact of nicotine on skin conditions, namely, by suppressing neutrophilmediated in ammatory actions (33). It is noteworthy that according to previous studies, it has been well understood that smoking is responsible for causing oxidative stress, leading to the production free radicals and various proin ammatory cytokines in in ammatory skin disease, (34)(35)(36).…”

Section: Discussionmentioning

confidence: 99%

The causal relationship between smoking behaviors and rosacea and Acne: Evidence from a Mendelian randomization

Gohari,

Golmohammadi,

Saeidian

et al. 2024

Preprint

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Previous observational studies have demonstrated positive associations between smoking patterns and the prevalence of acne and rosacea. However, the possible causal relationship remained unclear. Therefore, we conducted a Mendelian randomization (MR) study to investigate the potential causal association between smoking and these two common chronic inflammatory skin disorders. The summary statistics dataset related to smoking initiation and smoking behaviors were gathered from the published Genome-wide association study (GWAS) of 462,690 participants in the UK Biobank. The genetic variants associated with acne and rosacea were also obtained from the published GWAS of the FinnGen consortium which included 7,072,771 and 20,169,986 SNPs, respectively. Using these data, we conducted a two-sample MR analysis to determine the causal relationship between smoking behaviors and acne and rosacea. Our results show that lifetime smoking is significantly associated with a higher risk of acne (beta = 0.23, 95%; CI = (0.03, 0.43), SE = 0.10, Pbeta =0.02). Heterogeneity and pleiotropy tests revealed no evidence of heterogeneity or pleiotropy. However, no significant association was observed between smoking initiation and the risk of acne (beta = 0.02, 95%; CI (0.12, 0.14), SE = 0.073, Pbeta =0.71) (MR–Egger intercept = 0.013, P-value = 0.15). Despite no signs of pleiotropy, evidence of heterogeneity was found. Regarding rosacea, our findings determine a significant correlation between smoking behaviors, including smoking initiation and lifetime smoking, and an elevated risk of rosacea (beta = 0.34; 95% CI (0.11, 1.47), SE = 0.15, Pbeta= 0.02) (beta = 0.79; 95% CI (0.11, 1.47), SE = 0.34, Pbeta= 0.02). No evidence of heterogeneity or pleiotropy was also observed. Our study suggests a causal relationship between smoking behaviors and both acne and rosacea. These findings can be beneficial in terms of providing additional perspectives on healthcare decision policies.

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Evaluation of demodicosis, nailfold capillaroscopy, and oxidative stress in rosacea: a case-control study

Cited by 5 publications

References 34 publications

Evaluation of serum TWEAK, TRAIL, and oxidative stress markers in rosacea patients

Evaluation of serum TWEAK, TRAIL, and oxidative stress markers in rosacea patients

Investigation of skincare habits and possible rosacea triggers of patients with rosacea: A prospective case–control study

The causal relationship between smoking behaviors and rosacea and Acne: Evidence from a Mendelian randomization

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