Evaluation of Demineralized Bone Matrix Paste and Putty in Periodontal Intraosseous Defects

Bender, S.A; Rogalski, Joanna B.; Mills, Michael P.; Arnold, Ralph M.; Cochran, David L.; Mellonig, James T.

doi:10.1902/jop.2005.76.5.768

Cited by 51 publications

(48 citation statements)

References 37 publications

(38 reference statements)

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“…The reconstructions may be done with autogenous bone and synthetic or natural material [13][14][15][16] . Autogenous bone is regarded as the material of choice for bone reconstructions, although it may present some disadvantages such as greater surgical morbidity due to the need for a second surgical site 17 .…”

Section: ■ Discussionmentioning

confidence: 99%

“…Several materials have been studied and used as bone substitutes in order to avoid the use of autogenous bone 19 . Among these, demineralized bone matrix 7,13,18 and calcium phosphate cement 2,14,20,21 deserve special mention. The present study used bovine demineralized bone matrix (Gen-oxorg ® , Baumer) based on Torricelli et al 25 , who showed that xenogenous materials may be more osteoinductive than human ones.…”

Section: ■ Discussionmentioning

confidence: 99%

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Demineralized bone matrix and calcium-phosphate cement in bone regeneration in rats

Silva

Porto²,

Andrade³

et al. 2018

Acta Cir. Bras.

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Purpose: To compare bone regeneration in critical-sized defects in rat calvarium using demineralized bone matrix and calcium phosphate cement. Methods: Thirty Wistar rats were divided into 3 groups of 10 animals each. Two defects of 5-mm were made in the parietal bones of each animal. Group I had calcium phosphate cement placed in the experimental defect, Group II had filled with demineralized bone matrix and Group III had with the combination of the matrix and cement in equal parts. All animals had one defect left unfilled to serve as controls. Five animals in each group were sacrificed at 4 and 8 weeks. Histomorphometric analysis was used to quantify the amount of new bone within the defects. Results:The results showed that demineralized bone matrix-treated defects had significantly more new bone at 4 weeks compared to calcium phosphate cement-treated defects (p=0.03) and also had significantly more new bone at 8 weeks compared to unfilled defects (p=0.04). Conclusions: The demineralized bone matrix was superior to calcium phosphate cement in bone regeneration. It seems that calcium phosphate cement acted by inhibiting the osteogenesis when associated with a demineralized bone matrix and this combination should not be recommended.

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Section: ■ Discussionmentioning

confidence: 99%

Section: ■ Discussionmentioning

confidence: 99%

Demineralized bone matrix and calcium-phosphate cement in bone regeneration in rats

Silva

Porto²,

Andrade³

et al. 2018

Acta Cir. Bras.

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“…4,[23][24][25] The benefits of demineralized bone matrix with corticocancellous chips include its unlimited supply, its combined osteoconductive and osteoinductive properties (due to bioactive growth factors bone morphogenetic protein-2, vascular endothelial growth factor, fibroblast growth factor-α, and transforming growth factor-β1), and absence of donor-site morbidity to the patient. 25 The combination of demineralized bone matrix and allograft bone has been used successfully in pediatric patients without growth abnormalities, but its use thus far has been limited.…”

Section: Discussionmentioning

confidence: 99%

Management of Failed Alveolar Bone Grafts

Sivak

MacIsaac

Rottgers

et al. 2014

Plastic and Reconstructive Surgery

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“…It presents osteoinductive and osteoconductive properties. These properties are known experimentally since the work of Urist in the 70s (16)(17)(18)(19). DBX consists in demineralised bone to which an organic carrier is added (sodium hyaluronate).…”

Section: Discussionmentioning

confidence: 99%

“…There is a lot of literature supporting its use as an accelerator of the bone healing. This biomaterial presents multiple applications in oral and craniomaxillofacial surgery (16)(17)(18)(19) . We have noticed that demineralised bone matrix accelerates significantly bone formation in the studied defect.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of platelet-rich plasma, hydroxyapatite, demineralized bone matrix and autologous bone to promote bone regeneration after mandibular impacted third molar extraction.

Arenaz-Búa¹,

Luaces-Rey²,

Sironvalle-Soliva³

et al. 2010

Med Oral

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A comparative study of platelet-rich plasma, hydroxyapatite, demineralized bone matrix and autologous bone to promote bone regeneration after mandibular impacted third molar extraction AbstractObjectives: 1) to compare mandibular bone regeneration by applying autologous bone, platelet-rich plasma and two biomaterials (synthetic calcium hydroxyapatite, and demineralized bone matrix), and thus establish the potential benefits of these biomaterials in the regeneration of postextraction alveolar bone, 2) to identify wich of them accelerates more bone regeneration and 3) to determine whether there are differences in the postoperative period (pain, swelling, trismus, infection) depending on the material used. Study Design: It consists in a prospective, controlled (with a split-mouth design) and double blinded study. We use as a model an easily reproducible non-critical bone defect: the defect that remains after extraction of mandibular impacted third molar. The study design is based on the extraction of two mandibular impacted third molars in a patient during the same surgical procedure by the same surgeon. We assessed postoperative clinical data, and short, medium and long term neoformation of alveolar bone after extraction. We compared the two sockets (right and left), which had been grafted in a different way with the various elements mentioned above. In addition, we compared the postoperative inflammatory symptoms between groups. Results: The highest acceleration in bone formation was observed in groups in which we used autologous bone and demineralized bone matrix. There were no statistically significant differences between groups regarding pain, swelling, trismus and infection throughout the postoperative period. Conclusions: According to the results of our study, autologous bone persists as the gold standard material for bone regeneration. Among the assessed biomaterials, demineralized bone matrix has yielded the best results obtained. No significant differences in the postoperative (pain, swelling, trismus and infectious events) were observed, depending on the type of material used as a graft.

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Evaluation of Demineralized Bone Matrix Paste and Putty in Periodontal Intraosseous Defects

Abstract: In summary, demineralized bone matrix paste, demineralized bone matrix putty, and demineralized freeze-dried bone allograft all demonstrated similar favorable improvements in soft and hard tissue parameters in the treatment of human intraosseous defects.

Cited by 51 publications

References 37 publications

Demineralized bone matrix and calcium-phosphate cement in bone regeneration in rats

Demineralized bone matrix and calcium-phosphate cement in bone regeneration in rats

Management of Failed Alveolar Bone Grafts

A comparative study of platelet-rich plasma, hydroxyapatite, demineralized bone matrix and autologous bone to promote bone regeneration after mandibular impacted third molar extraction.

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