Evaluation of delayed additional FDG PET imaging in patients with pancreatic tumour

Nishiyama, Yoshihiro; Yamamoto, Y.; Monden, Toshihide; Sasakawa, Yasuhiro; Tsutsui, Kunihiko; Wakabayashi, Hisao; Ohkawa, Motoomi

doi:10.1097/00006231-200510000-00008

Cited by 55 publications

(27 citation statements)

References 15 publications

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“…The retention index (RI) is defined as the difference in standardized uptake value between early and late imaging expressed as a percentage of the initial uptake (RI= (SUV delayed − SUV early )/SUV early × 100%). These reports have generally been favorable showing improvement in detection or contrast for brain [2], breast [3], lung [4], pancreas [5][6][7], gallbladder [8], hepatocellular [9], cervical [10,11], intra-abdominal [12], intra-thoracic [13], soft-tissue [14], and other tumors [15,16]. For nasopharyngeal carcinoma, high sensitivity did not improve with delayed imaging [17].…”

Section: Discussionmentioning

confidence: 99%

Increasing Uptake Time in FDG-PET: Standardized Uptake Values in Normal Tissues at 1 versus 3 h

et al. 2008

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On FDG imaging at 3 h compared to 1 h, significant changes were apparent, but the magnitude of changes was modest overall. Three-hour delayed imaging demonstrated significantly lower aortic blood pool and adipose tissue activity and significantly higher cerebellum, muscle, spleen, and bone marrow activity. Hepatic and lung activities were not significantly different. These results suggest that previously reported improvements in tumor image contrast with delayed imaging may be primarily due to cumulative FDG uptake within the tumor rather than reduction in normal background activity.

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Section: Discussionmentioning

confidence: 99%

Increasing Uptake Time in FDG-PET: Standardized Uptake Values in Normal Tissues at 1 versus 3 h

et al. 2008

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“…The authors concluded that even though in patients with hepatocarcinoma the delayed PET acquisition did not bring any benefits (probably due to the similar FDG metabolism in well-differentiated hepatocarcinoma and in normal liver tissue [20,21]), delayed images proved useful in patients with liver metastases from colorectal cancer [22]. Finally, Nishiyama et al [23] studied the utility of PET in 86 patients with suspected pancreatic cancer acquiring early (1 h postinjection) and delayed (2 h postinjection) PET scans. They concluded that the mean lesion SUV of the delayed exam was significantly higher compared with that of the early one.…”

Section: Discussionementioning

confidence: 99%

“…They concluded that the mean lesion SUV of the delayed exam was significantly higher compared with that of the early one. Moreover, the delayed PET scan enabled identification of further liver metastases [23].…”

Section: Discussionementioning

confidence: 99%

Dual-phase FDG-PET: delayed acquisition improves hepatic detectability of pathological uptake

Arena¹,

Skanjeti²,

Casoni³

et al. 2008

Radiol med

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“…The findings were considered to be positive when both of the radiologists strongly suspected malignant disease. In addition, the images were analyzed semiquantitatively using the SUV, as reported elsewhere [7] . Briefly, regions of interest measuring 1.0 cm 2 were drawn over the area of maximum activity in a lesion.…”

Section: Fdg-petmentioning

confidence: 99%

Role of 18F-fluorodeoxyglucose positron emission tomography imaging in surgery for pancreatic cancer

Wakabayashi¹,

Nishiyama²,

Otani³

et al. 2008

WJG

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AIM:To evaluate the role of positron emission tomography using 18F-fluorodeoxyglucose (FDG-PET) in the surgical management of patients with pancreatic cancer, including the diagnosis, staging, and selection of patients for the subsequent surgical treatment. METHODS:This study involved 53 patients with proven primary pancreatic cancer. The sensitivity of diagnosing the primary cancer was examined for FDG-PET, CT, cytological examination of the bile or pancreatic juice, and the serum levels of carcinoembrionic antigens (CEA) and carbohydrate antigen 19-9 (CA19-9). Next, the accuracy of staging was compared between FDG-PET and CT. Finally, FDG-PET was analyzed semiquantitatively using the standard uptake value (SUV). The impact of the SUV on patient management was evaluated by examining the correlations between the SUV and the histological findings of cancer. RESULTS:The sensitivity of FDG-PET, CT, cytological examination of the bile or pancreatic juice, and the serum levels of CEA and CA19-9 were 92.5%, 88.7%, 46.4%, 37.7% and 69.8%, respectively. In staging, FDG-PET was superior to CT only in diagnosing distant disease (bone metastasis). For local staging, the sensitivity of CT was better than that of FDG-PET. The SUV did not correlate with the pTNM stage, grades, invasions to the vessels and nerve, or with the size of the tumor. However, there was a statistically significant difference (4.6 ± 2.9 vs 7.8 ± 4.5, P = 0.024) in the SUV between patients with respectable and unresectable disease.CONCLUSION: FDG-PET is thus considered to be useful in the diagnosis of pancreatic cancer. However, regarding the staging of the disease, FDG-PET is not considered to be a sufficiently accurate diagnostic modality. Although the SUV does not correlate with the patho-histological prognostic factors, it may be useful in selecting patients who should undergo subsequent surgical treatment.

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Evaluation of delayed additional FDG PET imaging in patients with pancreatic tumour

Abstract: The RI values obtained using early and delayed FDG PET may help in evaluating pancreatic cancer. Furthermore, addition of delayed FDG PET imaging is helpful to identify more lesions in patients with pancreatic cancer.

Cited by 55 publications

References 15 publications

Increasing Uptake Time in FDG-PET: Standardized Uptake Values in Normal Tissues at 1 versus 3 h

Increasing Uptake Time in FDG-PET: Standardized Uptake Values in Normal Tissues at 1 versus 3 h

Dual-phase FDG-PET: delayed acquisition improves hepatic detectability of pathological uptake

Role of 18F-fluorodeoxyglucose positron emission tomography imaging in surgery for pancreatic cancer

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