Evaluation of Dehydroepiandrosterone Sulfate (DHEA-S) Levels in Cystic Fibrosis

Shaffer, L. Blaine; Abid, Shariq; Jain, Raksha

doi:10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6178

Cited by 3 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In one small study, serum testosterone levels in five ovulatory CF women were found to be comparable to fifteen ovulatory non-CF women [56] . More recently, Shaffer and colleagues reported lower DHEA-S levels in CF women compared to CF men and non-CF women despite comparable levels between non-CF women and men [57] . It is not clear currently what the clinical implications of the reduced DHEA-S level might be but this may be a contributing factor to increased inflammation seen in CF women.…”

Section: Impact Of Sex Hormones On Immunity and Infectionmentioning

confidence: 98%

“…More recently, S haffer et al . [ 56 ] reported lower DHEA-S levels in CF women compared to CF men and non-CF women despite comparable levels between non-CF women and men. It is not clear currently what the clinical implications of the reduced DHEA-S level might be, but this may be a contributing factor to the increased inflammation seen in CF women.…”

Section: Effects Of Female Sex Hormones On Cf Pathophysiologymentioning

confidence: 99%

See 1 more Smart Citation

Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes

et al. 2020

View full text Add to dashboard Cite

Sex differences in morbidity and mortality have been reported in the cystic fibrosis (CF) population worldwide. However, it is unclear why CF women have worse clinical outcomes than men. In this review, we focus on the influence of female sex hormones on CF pulmonary outcomes and summarise data from in vitro and in vivo experiments on how estrogen and progesterone might modify mucociliary clearance, immunity and infection in the CF airways. The potential for novel sex hormone related therapeutic interventions is also discussed.

show abstract

Section: Impact Of Sex Hormones On Immunity and Infectionmentioning

confidence: 98%

Section: Effects Of Female Sex Hormones On Cf Pathophysiologymentioning

confidence: 99%

Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The most important aspect in relation to CF is that DHEA shows antifibrotic properties, by inhibiting cell proliferation and inducing early cell cycle arrest by suppressing glucose-6phosphate dehydrogenase activity in lung fibroblasts (47). Several reports confirm the reduced level of DHEA in the course of CF (11,48,49). DHEA has also been shown to decrease in states of malnutrition, such as anorexia nervosa (50).…”

Section: Discussionmentioning

confidence: 77%

Changes of androgen and corticosterone metabolites excretion and conversion in cystic fibrosis

Podgórski,

Sumińska,

Rachel

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

Cystic fibrosis (CF) is a life-threatening inherited disease related to a mutation in the CFTR gene, that leads to serious health complications such as chronic pulmonary infections, pancreatic insufficiency, dysfunction of the sweat glands and reproductive system. For the first time, we have described the profile of corticosterone and androgen metabolites in urine, as well as the activity of enzymes involved in steroid genesis and metabolism in people with CF, using gas chromatography/mass spectrometry. A significant reduction in the excretion of most of the measured metabolites in CF was found. These differences were observed in the group of progestagen metabolites, as well as among metabolites of corticosterone and androgens. We revealed higher activities of 17β-hydroxysteroid dehydrogenase and 17,20-lyase in the Δ4 pathway compared with controls, what can promote the androgen synthesis through the backdoor androgen pathway. We have also found the increased conversion activity of 11-oxyganated steroids by 5a-reductase in backdoor pathway. Levels of the most potent and vital androgens (testosterone and dihydrotestosterone) are comparable in both groups. However, the excretion of dehydroepiandrosterone was lower in CF. Decreased cholesterol lipoprotein levels may contribute to limited intracellular cholesterol supply and reduced adrenal steroidogenesis in CF individuals. Changes in the activity of some steroidogenesis enzymes may suggest the presence of some peripheral adaptive mechanisms in CF to maintain androgen balance in the body despite the limited sufficiency of secretion by the adrenal cortex.

show abstract

“…The results of pathway analysis using final candidates in our study identified that the steroid hormone biosynthesis pathway is associated with RA, as reported in other studies (Figure ). Meanwhile, DHEAS has an anti‐inflammatory effect and is known to be associated with immunomodulatory activity 34 . In addition, it has been reported that the change in DHEAS concentration is related to the severity and duration of RA 35 .…”

Section: Discussionmentioning

confidence: 99%

“…Meanwhile, DHEAS has an anti-inflammatory effect and is known to be associated with immunomodulatory activity. 34 In addition, it has been reported that the change in DHEAS concentration is related to the severity and duration of RA. 35 Therefore, our results support these existing results.…”

Section: Final Candidate Selectionmentioning

confidence: 99%

A discovery of screening markers for rheumatoid arthritis by liquid chromatography mass spectrometry: A metabolomic approach

et al. 2020

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is a chronic autoimmune disease in which the synovial joints are inflamed and swollen and the bone is eroded. About 1% of the adult population worldwide suffers from RA 2 and it is more common in women than in men. The discovery of biomarkers that can lead to earlier diagnosis and possible prevention will aid in reducing joint damage and improving disease prognosis. 3 However, rheumatoid factor (RF), currently known as a representative diagnostic marker for RA, is easily detected in other inflammatory diseases

show abstract

Evaluation of Dehydroepiandrosterone Sulfate (DHEA-S) Levels in Cystic Fibrosis

Cited by 3 publications

References 0 publications

Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes

Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes

Changes of androgen and corticosterone metabolites excretion and conversion in cystic fibrosis

A discovery of screening markers for rheumatoid arthritis by liquid chromatography mass spectrometry: A metabolomic approach

Contact Info

Product

Resources

About