Evaluation of Deferoxamine In Iron Overload

Hwang, Yun-Fei

doi:10.1001/archinte.1964.03860120053003

Cited by 41 publications

(20 citation statements)

References 14 publications

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“…Two of the three patients in whom the results were above normal had suffered from gastrointestinal bleeding but it is unlikely that contamination of urine with blood would account for the results obtained. Normal or high levels of urinary iron excretion after the administration of chelating agents have also been found by other workers in iron deficiency (Hwang and Brown, 1964). A possible explanation for this phenomenon is that in such patients a small amount of storage iron remained but that it was being rapidly mobilized and therefore was mostly in chelatable form.…”

Section: Serum Iron and Urinary Ironsupporting

confidence: 54%

Use of diethylenetriamine penta-acetic acid (D.T.P.A.) in the clinical assessment of total body iron stores

Powell

Thomas

1967

Journal of Clinical Pathology

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Section: Serum Iron and Urinary Ironsupporting

confidence: 54%

Use of diethylenetriamine penta-acetic acid (D.T.P.A.) in the clinical assessment of total body iron stores

Powell

Thomas

1967

Journal of Clinical Pathology

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“…The gaseous and mineral products were dissolved in 10% HNO 3. Atomic absorption measurements were made either directly (2--30 tzg/ml) (Perkin-Elmer, model 403) or after dilution to 0.005~0.150 ~g/ml with a graphite furnace (Perkin-Elmer, HGA-70) [11,12]. Iron in urine was determined by the same procedure from 200 tzl dried on anion-free filter paper.…”

Section: Methodsmentioning

confidence: 99%

“…Urinary iron excretion (~g/24h) ranged from 714--1240 in six successive 24-h periods (normal range 40--150) [ 11]. Bone marrow puncture showed a normal cytology.…”

Section: Case Reportmentioning

confidence: 99%

A metabolic disorder similar to Zellweger syndrome with hepatic acatalasia and absence of peroxisomes, altered content and redox state of cytochromes, and infantile cirrhosis with hemosiderosis

Versmold¹,

Bremer

Herzog

et al. 1977

Eur J Pediatr

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A patient with a cerebro-hepato-renal syndrome was investigated. The visceral manifestations were those of the Zellweger syndrome (ZS); however, the child exhibited muscular hypertonia and survived into the 2nd year of life. Ultramicroscopically, hepatocytes were lacking peroxisomes, but, contrary to findings in one patient with ZS [2], contained smooth endoplasmic reticulum. No catalase was found by histochemistry or spectroscopy. Mitochondria showed normal succinate and glutamate respiration, and normal coupling of respiration to the phosphorylation potential. The cytochrome (cyt) content was diminished to one-third with an abnormally inversed redox pattern of the respiratory chain in the controlled state, cyt b being 5%, cyt c 23% reduced. The oxygen affinity of cyt a3 was normal. These findings exclude a defect in the nonheme iron protein region of the respiratory chain as described in ZS [2], but point to a functional abnormality of cyt b in out patient.

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“…Of these two agents, DFA is easier to administer as it can be given intramuscularly and it is well tolerated. Most reports on the use of DFA in thalassaemia were confined to short-term trials (Smith, 1962; Hwang and Brown, 1964;McDonald, 1966;Diwany et al, 1968;Markum et al, 1969). Moreover, measurement of urinary iron excretion was the only criterion of response, and this does not provide evaluation of its clinical benefits.…”

mentioning

confidence: 99%

Long-term administration of desferrioxamine in thalassaemia major

Seshadri¹,

Colebatch²,

Gordon³

et al. 1974

Archives of Disease in Childhood

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(1974). Archives of Disease in Childhood, 49,621. Long-term administration of desferrioxamine in thalassaemia major. Studies of desferrioxamine (DFA) as a specific iron-chelating agent in the treatment of haemosiderosis have been reported in various conditions, but there has been only limited evaluation of its long-term use in thalassaemia major. In the present study 1 g DFA was given intramuscularly daily 6 days per week in 3 patients for 5 to 8 years, and in another 7 patients for 10 to 22 months. In addition, 500 mg DFA was added to each unit of donor blood at the time of transfusions. Urinary iron excretion after DFA was estimated using atomic absorption spectrophotometry both before and periodically during DFA treatment. During follow-up, cardiac and liver functions were assessed by ECG, chest x-ray, and liver function tests.The results show that DFA therapy increased urinary iron excretion, and that this was associated with a significant improvement in the clinical symptoms and signs of haemosiderosis and with return towards normal in the ECG and liver function tests.

show abstract

Evaluation of Deferoxamine In Iron Overload

Cited by 41 publications

References 14 publications

Use of diethylenetriamine penta-acetic acid (D.T.P.A.) in the clinical assessment of total body iron stores

Use of diethylenetriamine penta-acetic acid (D.T.P.A.) in the clinical assessment of total body iron stores

A metabolic disorder similar to Zellweger syndrome with hepatic acatalasia and absence of peroxisomes, altered content and redox state of cytochromes, and infantile cirrhosis with hemosiderosis

Long-term administration of desferrioxamine in thalassaemia major

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