Evaluation of Decellularized Bovine Tendon Sheets for Achilles Tendon Defect Reconstruction in a Rabbit Model

Zhang, Chenghao; Jiang, Yanlin; Ning, Liang-Ju; Li, Qi; Fu, Weili; Zhang, Yanjing; Xia, Chunchao; Li, Jian; Qin, Tingwu

doi:10.1177/0363546518787515

Cited by 18 publications

(16 citation statements)

References 55 publications

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“…Controlling the macrophage polarization by manipulating the nanomorphology of biomaterial surface may be an effective way to improve the performance of biomaterials ( Ma et al, 2014 ). MSCs exosomes-mediated response in cartilage repair was also found to be associated with regenerative M2 macrophages ( Zhang C.H. et al, 2018 ).…”

Section: Role Of Macrophages In Ecm-mediated Tissue Regenerationmentioning

confidence: 99%

Host Response to Biomaterials for Cartilage Tissue Engineering: Key to Remodeling

Liu

Chen

et al. 2021

Front. Bioeng. Biotechnol.

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Biomaterials play a core role in cartilage repair and regeneration. The success or failure of an implanted biomaterial is largely dependent on host response following implantation. Host response has been considered to be influenced by numerous factors, such as immune components of materials, cytokines and inflammatory agents induced by implants. Both synthetic and native materials involve immune components, which are also termed as immunogenicity. Generally, the innate and adaptive immune system will be activated and various cytokines and inflammatory agents will be consequently released after biomaterials implantation, and further triggers host response to biomaterials. This will guide the constructive remolding process of damaged tissue. Therefore, biomaterial immunogenicity should be given more attention. Further understanding the specific biological mechanisms of host response to biomaterials and the effects of the host-biomaterial interaction may be beneficial to promote cartilage repair and regeneration. In this review, we summarized the characteristics of the host response to implants and the immunomodulatory properties of varied biomaterial. We hope this review will provide scientists with inspiration in cartilage regeneration by controlling immune components of biomaterials and modulating the immune system.

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Section: Role Of Macrophages In Ecm-mediated Tissue Regenerationmentioning

confidence: 99%

Host Response to Biomaterials for Cartilage Tissue Engineering: Key to Remodeling

Liu

Chen

et al. 2021

Front. Bioeng. Biotechnol.

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“…Although the mechanism of tendon graft repair is poorly understood, adhesion formation with autografts is believed to arise from intrinsic (tenocyte necrosis) and extrinsic fibrosis (influx of synovial and inflammatory cells), leading to excessive scarring [59,76,77]. Other research reported minimal formation of adhesion using acellular allografts on bovine flexor tendon repair [78,79] indicating that acellular allografts can heal without the intrinsic healing mechanism, often observed in autograft tissue.…”

Section: Graft Transplantation Techniquesmentioning

confidence: 99%

Polymer-Based Constructs for Flexor Tendon Repair: A Review

Brebels

Mignon

2022

Polymers

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A flexor tendon injury is acquired fast and is common for athletes, construction workers, and military personnel among others, treated in the emergency department. However, the healing of injured flexor tendons is stretched over a long period of up to 12 weeks, therefore, remaining a significant clinical problem. Postoperative complications, arising after traditional tendon repair strategies, include adhesion and tendon scar tissue formation, insufficient mechanical strength for early active mobilization, and infections. Various researchers have tried to develop innovative strategies for developing a polymer-based construct that minimalizes these postoperative complications, yet none are routinely used in clinical practice. Understanding the role such constructs play in tendon repair should enable a more targeted approach. This review mainly describes the polymer-based constructs that show promising results in solving these complications, in the hope that one day these will be used as a routine practice in flexor tendon repair, increasing the well-being of the patients. In addition, the review also focuses on the incorporation of active compounds in these constructs, to provide an enhanced healing environment for the flexor tendon.

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“…Techniques usually combine a biomimetic scaffold with biological factors, such as cells and growth factors to provide physical and biochemical cues for tissue growth [65]. Scaffolds obtained from decellularized sources (e.g., human [66,67], porcine [68], canine [69], bovine [70] and equine) are used; however, required donor tissues have weaker mechanical properties and are associated with a high risk of immunogenicity [71,72].…”

Section: Biomimicry Of Soft Tissuesmentioning

confidence: 99%

The Future Application of Nanomedicine and Biomimicry in Plastic and Reconstructive Surgery

Amin

Moscalu

Imere

et al. 2019

Nanomedicine (Lond.)

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Plastic surgery encompasses a broad spectrum of reconstructive challenges and prides itself upon developing and adopting new innovations. Practice has transitioned from microsurgery to supermicrosurgery with a possible future role in even smaller surgical frontiers. Exploiting materials on a nanoscale has enabled better visualization and enhancement of biological processes toward better wound healing, tumor identification and viability of tissues, all cornerstones of plastic surgery practice. Recent advances in nanomedicine and biomimicry herald further reconstructive progress facilitating soft and hard tissue, nerve and vascular engineering. These lay the foundation for improved biocompatibility and tissue integration by the optimization of engineered implants or tissues. This review will broadly examine each of these technologies, highlighting areas of progress that reconstructive surgeons may not be familiar with, which could see adoption into our armamentarium in the not-so-distant future.

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Evaluation of Decellularized Bovine Tendon Sheets for Achilles Tendon Defect Reconstruction in a Rabbit Model

Abstract: DBTSs could serve as an effective bioscaffold to reconstruct AT defects.

Cited by 18 publications

References 55 publications

Host Response to Biomaterials for Cartilage Tissue Engineering: Key to Remodeling

Host Response to Biomaterials for Cartilage Tissue Engineering: Key to Remodeling

Polymer-Based Constructs for Flexor Tendon Repair: A Review

The Future Application of Nanomedicine and Biomimicry in Plastic and Reconstructive Surgery

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