Evaluation of cytotoxicity of hematite nanoparticles in bacteria and human cell lines

Rajendran, Kumar; Sen, Shampa; Suja, G; Selvaraj, Senthil; Kumar, T. Vinoth

doi:10.1016/j.colsurfb.2017.05.052

Cited by 56 publications

(20 citation statements)

References 66 publications

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“…Journal of Nanomaterials 17.5°and 20°-26°appeared in the diffractogram of chitosan ( Figure 6) due to the amorphous nature of the polymeric compound. For HNPs (Figure 6), major diffraction peaks were found at 24.2°, 33 (Figure 7) and confirms the crystal structure of the akaganeite (FeO·OH) mineral (JCPDS card no. 0157-13).…”

Section: Resultssupporting

confidence: 71%

“…The materials, chemicals, and methods used in this synthesis process are cost-effective, facile, and easily industrialized. Also, the iron oxide/hydroxide nanomaterials that were used to reinforce the chitosan matrix are nontoxic and environmentally friendly [33,34]. Herein, eco-friendly polymer nanocomposites with enhanced properties are introduced, which could be considered as promising alternatives for petroleum-derived materials in future active packaging activities.…”

Section: Introductionmentioning

confidence: 99%

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Eco-Friendly, Green Packaging Materials from Akaganeite and Hematite Nanoparticle-Reinforced Chitosan Nanocomposite Films

Chandrakumara

Dissanayake

Mantilaka

et al. 2019

Journal of Nanomaterials

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In this study, chitosan nanocomposite thin films were successfully fabricated by incorporating hematite nanoparticles (HNPs) and akaganeite nanoparticles (ANPs) as reinforcing fillers using the solution casting method. HNPs and ANPs were synthesized via a urea-assisted synthesis route using naturally occurring ferruginous laterites. Scanning electron microscopic (SEM) images indicated the spherical to subhexagonal morphology of the HNPs and rice-like morphology of the ANPs. X-ray diffractograms indicate the crystalline structure of iron oxides as hematite and akaganeite. Tensile tests were carried out to evaluate the mechanical properties of the nanocomposite films where maximum tensile stress of the chitosan/HNP composites was improved as high as 35.7% while chitosan/ANP composites indicated 43.5%. Thermal decomposition curves obtained by thermogravimetric analysis (TGA) indicate that the thermal stability of the nanocomposites has improved remarkably compared to neat chitosan films. Furthermore, these nanocomposites exhibited excellent UV barrier properties as identified by UV-visible spectrometry. Fourier-transform infrared (FTIR) spectroscopic results are evident in the presence of Fe-O bond in the wavenumber around 480-500 cm -1 , and the result also indicated that the nanofillers interact with the chitosan matrix via hydrogen bonding, which enhanced the physical properties of the nanocomposites. Incorporation of iron oxide nanoparticle varieties into chitosan has led to improvements of certain physical and chemical properties, which make chitosan a promising material for packaging applications.

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Section: Resultssupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Eco-Friendly, Green Packaging Materials from Akaganeite and Hematite Nanoparticle-Reinforced Chitosan Nanocomposite Films

Chandrakumara

Dissanayake

Mantilaka

et al. 2019

Journal of Nanomaterials

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“…Furthermore, the results of this study are consistent with Anderson et al who found that ovine‐derived peptides SMAP29 induced cell death of S. aureus through cell wall destruction. On the other hand, Rajendran et al reported that HNPs (up to 25 mg mL −1 ) did not show straightforward inhibitory effect on the bacteria, which makes these results advantageous.…”

Section: Resultsmentioning

confidence: 99%

Study on the Antagonistic Potential of Biosynthesized Hematite Nanoparticles During Water and Wastewater Treatment

Eltarahony

Zaki

Kheiralla

et al. 2019

CLEAN Soil Air Water

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Microbial pollution of water is one of the hazardous factors that threaten public health and the surrounding ecosystem. Therefore, the development of environmentally benign nanoparticles with exceptional properties has increased the drive toward improvement of water/wastewater disinfection. Accordingly, we aim to address the antagonistic effect of biogenic hematite nanoparticles (HNPs) against a broad spectrum of microorganisms and in water/wastewater disinfection systems. The minimum inhibitory concentration of HNPs at a range of 0.075–9.6 mg mL−1 is examined. The results demonstrate that Gram‐positive bacteria are more susceptible to HNPs than Gram‐negative ones. In addition, the growth of Candida albicans and Aspergillus brasiliensis is inhibited by applying 1.2 mg mL−1 of HNPs, which indicates antifungal activity. Moreover, HNPs (0.3 mg mL−1) inhibits 58.7, 50.5, and 86.3% of the growth of Staphylococcus aureus, Pseudomonas aeruginosa biofilms, and Chlorella vulgaris, respectively. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) of untreated and HNPs‐treated cells of Escherichia coli, Staphylococcus aureus, Clostridium perfringens, Candida albicans, and Chlorella vulgaris are studied, and the ultrastructure micrographs show ultrastructure deformities caused by HNPs. Remarkable disinfection strength reaches up to 99.8%, mainly with increasing dose and contact time. The current study highlights the efficiency of HNPs as a biocide, which could contribute to water/wastewater treatment as an alternative for chlorine.

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“…Similar result was observed on the same HEK-293 cell line by Kavya et al where iron oxide nanoparticle was prepared using agrowastes of various plants [ 41 ]. The cytotoxicity of bacterial enzymatic synthesis ferric oxide nanoparticles was evaluated against the cancer cell lines and normal vero cell line and observed that the biologically synthesized iron oxide nanoparticles are non-toxic to normal cells but were potentially lethal to the cancer cells [ 42 ]. The cytotoxicity of the chemically synthesized MgO nanoparticles was observed by Mahmoud et al [ 43 ] where the LC 50 was attained at less than 300 μg/mL.…”

Section: Resultsmentioning

confidence: 99%

Surface modification of Fe2O3 and MgO nanoparticles with agrowastes for the treatment of chlorosis in Glycine max

Nazeer¹,

Udhayakumar²,

Mani³

et al. 2018

Nano Convergence

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Surface modification of nanoparticles for biological applications is receiving enormous interest among the research community due to the ability to alchemy the toxic nanoparticles into biocompatible compounds. In this study, the agrowastes of Moringa oleifera and Coriandrum sativum were used to surface modify the magnesium oxide nanoparticles and ferric oxide nanoparticles respectively. The agrowaste amended magnesium oxide nano particles (AMNP) and agrowaste amended ferric oxide nanoparticles (AFNP) were characterized using scanning electron microscope, X-ray diffractometer, Fourier transformed-infra red spectroscope to justify the formation and surface modification of nanoparticles with the organic functional groups from the agro wastes. The surface modified nano particles were tested for their biocompatibility and ability to treat the chlorosis in Glycine max. On comparison between the two metal based nanoparticles, AMNP exhibited better chlorosis treating ability than the AFNP. Both the nano particles showed increased potency at minimal amount, 30 μg and the higher concentrations till 125 μg exhibited down run of the potency which was again enhanced from 250 μg of nanoparticle treatment to plants. Further the surface modified nanoparticles were assessed for biocompatibility on human embryonic kidney (HEK-293) cell line which proved that the cell lines are non-toxic to normal human cells. The size of the particles and the concentration is suggested to be responsible for the effective chlorosis treatment and the organic functional groups responsible for the reduction of toxicity of the particles to the plants.

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Evaluation of cytotoxicity of hematite nanoparticles in bacteria and human cell lines

Cited by 56 publications

References 66 publications

Eco-Friendly, Green Packaging Materials from Akaganeite and Hematite Nanoparticle-Reinforced Chitosan Nanocomposite Films

Eco-Friendly, Green Packaging Materials from Akaganeite and Hematite Nanoparticle-Reinforced Chitosan Nanocomposite Films

Study on the Antagonistic Potential of Biosynthesized Hematite Nanoparticles During Water and Wastewater Treatment

Surface modification of Fe2O3 and MgO nanoparticles with agrowastes for the treatment of chlorosis in Glycine max

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