Evaluation of cytotoxicity, genotoxicity, and zebrafish embryo toxicity of mixtures containing Hyssopus officinalis, Morus alba, Engraulis japonicus, and 27 other extracts for cosmetic safety assessment

Ha, Yuna; Kim, Young‐Jin; Choi, Jeongyeon; Hwang, In‐Chul; Ko, Ju-Young; Jeon, Hee Kyung; Kim, Youn-Jung

doi:10.1007/s13273-021-00128-7

Cited by 13 publications

(5 citation statements)

References 46 publications

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“…The growth and differentiation of HaCaT was conducted by previous method with slightly revise 15 . The immortalized HaCaT was divided from the tissue of a male aged >60 years old.…”

Section: Methodsmentioning

confidence: 99%

“…The growth and differentiation of HaCaT was conducted by previous method with slightly revise. 15 The immortalized HaCaT was divided from the tissue of a male aged >60 years old. The culture medium for HaCaT was composed of 89% DMEM, 10% of FBS, and 1% P/S with a low-calcium growth medium (0.03 mM of calcium).…”

Section: Human Immortalized Keratinocytes Cell (Hacat) Culture and Di...mentioning

confidence: 99%

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Bioconversion of retinol and its cell barrier function in human immortalized keratinocytes cells and artificial epidermis–dermis skin

Kim

et al. 2023

Experimental Dermatology

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“…The growth and differentiation of HaCaT was conducted by previous method with slightly revise 15 . The immortalized HaCaT was divided from the tissue of a male aged >60 years old.…”

Section: Methodsmentioning

confidence: 99%

Section: Human Immortalized Keratinocytes Cell (Hacat) Culture and Di...mentioning

confidence: 99%

Bioconversion of retinol and its cell barrier function in human immortalized keratinocytes cells and artificial epidermis–dermis skin

Kim

et al. 2023

Experimental Dermatology

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“…Exposome describes the totality of environmental exposure and its effects on health during the lifetime (Wild 2005). It helps to comprehend how unrecognizable but persistent environmental exposure in normal life (Ha et al 2021;Kim et al 2021) slowly affects our health through alteration of molecular processes (Rim and Kim 2020). Exposome is usually studied through cohort studies targeting specific population.…”

Section: Introductionmentioning

confidence: 99%

Sample management: a primary critical starting point for successful omics studies

Koh

Kim

Hwang

2022

Mol. Cell. Toxicol.

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Biological samples collected from cohort studies are widely utilized in molecular genetic studies and are typically stored long term for future applications, such as omics analyses. The extent of sample availability is determined by proper sample handling, and it is of primary importance for successful omics studies. However, questions on whether samples in long-term storage are properly available for omics experiments has been raised, because the quality and availability of such samples remain unknown until their actual utilization. In that perspective, several guidelines for proper sample management have been suggested. In addition, several researchers assessed how improper management damages sample using mock sample and suggested a set of requirements for sample handling. In this review, we present several considerations for sample handling eligible for omics studies. Focusing on birth cohorts, we describe the types of samples collected from which omics data were generated. This review ultimately aims to provide proper guidelines for sample handling for successful human omics studies.

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“…Toxicity assessment using zebrafish embryos has been suggested as a promising method to demonstrate the impact of environmental toxicants (An et al, 2021;Ha et al, 2021). Various studies have confirmed that reactivity to toxicants is highly similar between zebrafish and other fish species (Busquet et al, 2014;Birke and Scholz, 2019).…”

Section: Introductionmentioning

confidence: 99%

Norflurazon causes developmental defects including cardiovascular abnormalities in early-stage zebrafish (Danio rerio)

Park

Hong

et al. 2022

J Anim Reprod Biotechnol

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Norflurazon is widely used on agricultural lands and has a high potential to pollute water sources. However, its effects on fish have not been fully elucidated. The purpose of our study was to determine whether norflurazon adversely affects the developmental stage of zebrafish, which are frequently used as a model system to evaluate the environmental impact of pollutants. Norflurazon interfered with the hatching of zebrafish embryos and induced several sublethal deformities including body length reduction, increased yolk sac volume, and enlargement of the pericardial region. We further examined the cardiotoxicity of norflurazon in the flk1:eGFP transgenic zebrafish line. The vascular network, mainly in the brain region, was significantly disrupted in norflurazon-exposed zebrafish. In addition, due to the failure of cardiac looping, norflurazon-exposed zebrafish had an abnormal cardiac structure. These developmental abnormalities were related to the apoptotic process triggered by norflurazon. Overall, the present study demonstrated the non-target toxicity of norflurazon by analyzing the hazardous effects of norflurazon on developing zebrafish.

show abstract

Evaluation of cytotoxicity, genotoxicity, and zebrafish embryo toxicity of mixtures containing Hyssopus officinalis, Morus alba, Engraulis japonicus, and 27 other extracts for cosmetic safety assessment

Cited by 13 publications

References 46 publications

Bioconversion of retinol and its cell barrier function in human immortalized keratinocytes cells and artificial epidermis–dermis skin

Bioconversion of retinol and its cell barrier function in human immortalized keratinocytes cells and artificial epidermis–dermis skin

Sample management: a primary critical starting point for successful omics studies

Norflurazon causes developmental defects including cardiovascular abnormalities in early-stage zebrafish (Danio rerio)

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