Evaluation of Cytotoxic Potentials of Novel Cyclooxygenase-2 Inhibitor against ALL Lymphocytes and Normal Lymphocytes and Its Anticancer Effect through Mitochondrial Pathway

Salimi, Ahmad; Aghvami, Marjan; Movahed, Mahsa Azami; Zarei, Mohammad; Eshghi, Peyman; Zarghi, Afshin; Pourahmad, Jalal

doi:10.1080/07357907.2020.1808898

Cited by 2 publications

(3 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to our data, Vicent et al [46] also observed no expression of COX2 in blood samples taken from acute leukemia patients. However, in contrast to our findings, COX2 was reported as being up-regulated in ALL, and data concerning cancer cell lines, including leukemia cells, have revealed that COX2 inhibition reduces the growth of malignant cells [43,45]. Moreover, COX2 has been suggested to be a potential target for therapeutic intervention to suppress pediatric ALL and improve OS [43,47].…”

Section: Potential Biomarkers For Diagnosis and Prognosiscontrasting

confidence: 99%

“…However, in contrast to our findings, COX2 was reported as being up-regulated in ALL, and data concerning cancer cell lines, including leukemia cells, have revealed that COX2 inhibition reduces the growth of malignant cells [43,45]. Moreover, COX2 has been suggested to be a potential target for therapeutic intervention to suppress pediatric ALL and improve OS [43,47]. It is well known that COX2 is a pleiotropic protein, and no data from adults with ALL are available; thus, the relationship between COX2 gene and ALL remains undeciphered.…”

Section: Potential Biomarkers For Diagnosis and Prognosiscontrasting

confidence: 99%

“…In relation to down-regulated genes, PTGS2 and PPBP showed a very low expression in cases against controls. The overexpression of both genes has been associated with several human cancer types [42][43][44][45]. PTGS2 or cyclooxygenase 2 (COX2) encodes prostaglandinendoperoxide synthase, which is a relevant protein in oncogenic processes and has been shown to have a controversial association with ALL.…”

Section: Potential Biomarkers For Diagnosis and Prognosismentioning

confidence: 99%

See 2 more Smart Citations

Transcriptome Analysis in Mexican Adults with Acute Lymphoblastic Leukemia

Cruz-Miranda,

Olarte-Carrillo,

Bárcenas-López

et al. 2024

IJMS

View full text Add to dashboard Cite

Acute lymphoblastic leukemia (ALL) represents around 25% of adult acute leukemias. Despite the increasing improvement in the survival rate of ALL patients during the last decade, the heterogeneous clinical and molecular features of this malignancy still represent a major challenge for treatment and achieving better outcomes. To identify aberrantly expressed genes in bone marrow (BM) samples from adults with ALL, transcriptomic analysis was performed using Affymetrix Human Transcriptome Array 2.0 (HTA 2.0). Differentially expressed genes (DEGs) (±2-fold change, p-value < 0.05, and FDR < 0.05) were detected using the Transcriptome Analysis Console. Gene Ontology (GO), Database for Annotation, Visualization, and Integrated Discovery (DAVID), and Ingenuity Pathway Analysis (IPA) were employed to identify gene function and define the enriched pathways of DEGs. The protein–protein interactions (PPIs) of DEGs were constructed. A total of 871 genes were differentially expressed, and DNTT, MYB, EBF1, SOX4, and ERG were the top five up-regulated genes. Meanwhile, the top five down-regulated genes were PTGS2, PPBP, ADGRE3, LUCAT1, and VCAN. An association between ERG, CDK6, and SOX4 expression levels and the probability of relapse and death was observed. Regulation of the immune system, immune response, cellular response to stimulus, as well as apoptosis signaling, inflammation mediated by chemokines and cytokines, and T cell activation were among the most altered biological processes and pathways, respectively. Transcriptome analysis of ALL in adults reveals a group of genes consistently associated with hematological malignancies and underscores their relevance in the development of ALL in adults.

show abstract

Section: Potential Biomarkers For Diagnosis and Prognosiscontrasting

confidence: 99%

Section: Potential Biomarkers For Diagnosis and Prognosiscontrasting

confidence: 99%

Section: Potential Biomarkers For Diagnosis and Prognosismentioning

confidence: 99%

See 1 more Smart Citation

Transcriptome Analysis in Mexican Adults with Acute Lymphoblastic Leukemia

Cruz-Miranda,

Olarte-Carrillo,

Bárcenas-López

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

Cyclooxygenase-2 deficiency attenuates lipopolysaccharide-induced inflammation, apoptosis, and acute lung injury in adult mice

Nelin

Jin

Chen

et al. 2022

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Many lung diseases are caused by an excessive inflammatory response, and inflammatory lung diseases are often modeled using lipopolysaccharide (LPS) in mice. Cyclooxygenase-2 (COX-2) encoded by the Ptgs2 gene is induced in response to inflammatory stimuli including lipopolysaccharide (LPS). The objective of this study was to test the hypothesis that mice deficient in COX-2 (Ptgs2-/-) will be protected from LPS-induced lung injury. Wild type (WT, CD1 mice) and Ptgs2-/- mice (on a CD1 background) were treated with LPS or vehicle for 24 hours. LPS-treatment resulted in histological evidence of lung injury, which was attenuated in the Ptgs2-/- mice. LPS-treatment increased the mRNA levels for tumor necrosis factor (TNF)-α, interleukin (IL)-10, and monocyte chemoattractant protein (MCP)-1 in the lungs of WT mice, and the LPS-induced increases in these levels were attenuated in the Ptgs2-/- mice. The protein levels of active caspase-3 and caspase-9 were lower in the LPS-treated lungs of Ptgs2-/- mice than in LPS-treated WT mice, as were the number of TUNEL positive cells in lung sections. LPS exposure resulted in greater lung wet-to-dry weight ratio (W/D) in WT mice, suggestive of pulmonary edema; while in LPS-treated Ptgs2-/- mice the W/D was not different from controls and less than in LPS-treated WT mice. These results demonstrate that COX-2 is involved in the inflammatory response to LPS, and suggest that COX-2 not only acts as a downstream participant in the inflammatory response, but also acts as a regulator of the inflammatory response likely through a feed-forward mechanism following LPS stimulation.

show abstract

Evaluation of Cytotoxic Potentials of Novel Cyclooxygenase-2 Inhibitor against ALL Lymphocytes and Normal Lymphocytes and Its Anticancer Effect through Mitochondrial Pathway

Cited by 2 publications

References 42 publications

Transcriptome Analysis in Mexican Adults with Acute Lymphoblastic Leukemia

Transcriptome Analysis in Mexican Adults with Acute Lymphoblastic Leukemia

Cyclooxygenase-2 deficiency attenuates lipopolysaccharide-induced inflammation, apoptosis, and acute lung injury in adult mice

Contact Info

Product

Resources

About