Evaluation of cytotoxic potential, oral toxicity, genotoxicity, and mutagenicity of organic extracts of<i>Pityrocarpa moniliformis</i>

Purpose Despite wide research on bioremediation of hydrocarbon-contaminated soil, the mechanisms of surfactant-enhanced bioavailability of the contaminants are still unclear. The presented study was focused on the in-depth description of relationships between hydrocarbons, bacteria, and surfactants. In order to that, the biodegradation experiments and cell viability measurements were conducted, and the properties of cell surface were characterized. Methods MTT assay was employed to measure plant extracts toxicity to microbes. Then, membrane permeability changes were evaluated, followed by diesel oil biodegradation in the presence of surfactants measurements by GCxGC-TOFMS and PCR-RAPD analysis. Results Our study undoubtedly proves that different surfactants promote assimilation of different groups of hydrocarbons and modify cell surface properties in different ways. Increased biodegradation of diesel oil was observed when cultures with Acinetobacter calcoaceticus M1B were supplemented with Saponaria officinalis and Verbascum nigrum extracts. Interestingly, these surfactants exhibit different influences on cell surface properties and their viability in contrast to the other surfactants. Moreover, the preliminary analyses have shown changes in the genome caused by exposure to surfactants. Conclusions The results indicated that the benefits of surfactant use may be related to deep modification at the omics level, not only that of cell surface properties and confirms the complexity of the interactions between bacterial cells, pollutants and surfactants.

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Evaluation of the cytotoxicity, oral toxicity, genotoxicity, and mutagenicity of the latex extracted from Himatanthus drasticus (Mart.) Plumel (Apocynaceae)

Moura

Rocha

Barros

et al. 2020

Journal of Ethnopharmacology

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Evaluation of cytotoxic potential, oral toxicity, genotoxicity, and mutagenicity of organic extracts ofPityrocarpa moniliformis

Cited by 18 publications

References 58 publications

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Evaluation of the cytotoxicity, oral toxicity, genotoxicity, and mutagenicity of the latex extracted from Himatanthus drasticus (Mart.) Plumel (Apocynaceae)

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