Evaluation of cytotoxic activity of live toxoplasma gondii tachyzoites and toxoplasma antigen on MCF-7 human breast cancer cell line

Eissa, Maha M.; Gaafar, Maha R.; Younis, Layla K.; Ismail, Cherine A.; Skhawy, Nahla El

doi:10.21303/2504-5695.2022.002409

Cited by 1 publication

(1 citation statement)

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“…According to the recent research progress, it is worth mentioning that the components of T. gondii have good potential for anti-tumor applications. Eissa et al demonstrated that mice immunized with autoclaved Toxoplasma vaccine (ATV) produced 13.3% inhibition of Ehrlich solid carcinoma (ESC) genesis and confirmed the existence of at least four pairs of common antigens between ATV and ESC (Eissa et al, 2023). Subsequent results showed that ATV and cyclophosphamide synergistically exerted a stronger tumor immune response and anti-angiogenesis effect in ESC-bearing mice, indicating that ATV has the potential to be a tumor vaccine or cancer drug adjuvant (Ismail et al, 2023).…”

Section: Anti-tumor Potential Of T Gondii Componentsmentioning

confidence: 98%

A novel enemy of cancer: recent investigations into protozoan anti-tumor properties

Zheng,

Lu,

Zhou

et al. 2024

Front. Cell. Infect. Microbiol.

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Cancer remains a significant global health issue, despite advances in screening and treatment. While existing tumor treatment protocols such as surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy have proven effective in enhancing the prognosis for some patients, these treatments do not benefit all patients. Consequently, certain types of cancer continue to exhibit a relatively low 5-year survival rate. Therefore, the pursuit of novel tumor intervention strategies may help improve the current effectiveness of tumor treatment. Over the past few decades, numerous species of protozoa and their components have exhibited anti-tumor potential via immune and non-immune mechanisms. This discovery introduces a new research direction for the development of new and effective cancer treatments. Through in vitro experiments and studies involving tumor-bearing mice, the anti-tumor ability of Toxoplasma gondii, Plasmodium, Trypanosoma cruzi, and other protozoa have unveiled diverse mechanisms by which protozoa combat cancer, demonstrating encouraging prospects for their application. In this review, we summarize the anti-tumor ability and anti-tumor mechanisms of various protozoa and explore the potential for their clinical development and application.

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Section: Anti-tumor Potential Of T Gondii Componentsmentioning

confidence: 98%