Evaluation of Cytotoxic Activity of<i>Schisandra chinensis</i>Lignans

Šmejkal, Karel; Šlapetová, Tereza; Krmenčík, Pavel; Babula, Petr; Dall’Acqua, Stefano; Innocenti, Gabbriella; Vančo, Ján; Casarin, Elisabetta; Carrara, Maria; Kalvarová, Karolína; Dvorská, Margita; Slanina, Jiřı́; Kramárová, E; Julínek, Ondřej; Urbanová, Marie

doi:10.1055/s-0030-1249861

Cited by 33 publications

(22 citation statements)

References 22 publications

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“…Previously, tigloylgomisin P (2) had been reported to possess cytotoxicity against the Nicotiana BY-2 cell line (Smejkal et al, 2010) and schisanlactone B (8) was found to inhibit human cancer cell lines Bel-7402 and HL-60 (Wang et al, 2006). No prior literature had addressed the cytotoxicities of cagayanone (3), (À)-gomisin L 2 (4), micranoic acid B (5) and lancifodilactone H (6).…”

Section: Resultsmentioning

confidence: 99%

Cytotoxic and potential anticancer constituents from the stems ofSchisandra pubescens

Liu

et al. 2013

Pharmaceutical Biology

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Context: The diethyl ether extract of the stems of Schisandra pubescens Hemsl. et Wils. (Schisandraceae) was found to exhibit cytotoxic activity in vitro. However, investigations of the bioactive constituents of this plant have been very limited. Objective: Elucidation of the cytotoxic constituents of S. pubescens was performed. Methods: Repeated silica gel column chromatography and preparative TLC were used for the chemical investigation of the diethyl ether extract of S. pubescens stems. All isolates were evaluated for their in vitro cytotoxicity against A549, PC-3, KB and KBvin human cancer cell lines. Results: Nine known compounds were obtained, including four lignans, epischisandrone (1), tigloylgomisin P (2), cagayanone (3) and (À)-gomisin L 2 (4), together with five triterpenoids, micranoic acid B (5), lancifodilactone H (6), coccinic acid (7), schisanlactone B (8) and anwuweizonic acid (9). Compounds 2-6 and 8 showed moderate to marginal cytotoxicity, with GI 50 values of 11.83-35.65 mM. Conclusion: The isolation of 1-9 from S. pubescens and the cytotoxicities of 3-6 are first reported. Compounds 2-6 and 8 could be the active principles responsible for the anticancer effects of S. pubescens.

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Section: Resultsmentioning

confidence: 99%

Cytotoxic and potential anticancer constituents from the stems ofSchisandra pubescens

Liu

et al. 2013

Pharmaceutical Biology

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“…Recently a group from Johns Hopkins isolated lignans from Schisandra chinensis and demonstrated its anti-proliferative activity in human colorectal carcinoma (Gnabre et al, 2010) and cytotoxicity against colon cancer cell line LoVo (Smejkal et al, 2010). Their effects were reported on structure-activity relationships (Gnabre et al, 2010).…”

Section: Anti-cancermentioning

confidence: 99%

Panax ginsengRhodiola roseaandSchisandra chinensis

Chan

2011

International Journal of Food Sciences and Nutrition

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Panax ginseng (Ginseng), Rhodiola rosea (Hong Jing Tian) and Schisandra chinensis (Wu Wei Zi) are well-known herbs in traditional Chinese medicine (TCM). Recently, there have been a number of studies on these 3 herbs. This review discusses their active components and major pharmacological effects. For Panax ginseng, it has been shown to have an anti-inflammatory activity, affects pulmonary function and erectile dysfunction, improves cognition in patients with Alzheimer's disease and promotes sexual arousal in menopausal women as well as prevent cancer. For Rhodiola rosea, its effectiveness on alleviating depression and reducing fatigue are summarized in this review.Additionally, anti-cancer and other clinical effects of Schisandra chinensis are also discussed. These 3 herbs are considered as adaptogens as they bear multiple functions and their effects were found to be very different in subjects depending on the circumstances (age, gender, environment, diet, season, etc.). Thus, in most cases, the art of the TCM practitioner is to prescribe these herbs after a complete evaluation of patients' overall heath status.

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“…G.A has multiple biological activities including memory improving and hepatoprotective, antihypertensive, antidiabetic, and anti-inflammatory effects (Kim et al, 2006; Kwon et al, 2011; Park et al, 2012; Wang et al, 2014; Jiang et al, 2015). G.A also inhibits hepatocarcinogenesis and shows cytotoxicity against human CRC cell lines (LoVo, HCT116) and A2780 human ovarian cancer cells (Ohtaki et al, 1996; Smejkal et al, 2010; Hwang et al, 2011; Jeong et al, 2017). However, the effects of G.A on the metastatic phenotype and metastasis of CRC cells have not been elucidated using in vivo models.…”

Section: Introductionmentioning

confidence: 99%

Gomisin A Suppresses Colorectal Lung Metastasis by Inducing AMPK/p38-Mediated Apoptosis and Decreasing Metastatic Abilities of Colorectal Cancer Cells

et al. 2018

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Gomisin A (G.A) is a dietary lignan compound from Schisandra chinensis. In this study, the effect of G.A on the proliferation and metastasis of colorectal cancer (CRC) cells was investigated using several CRC cell lines and a lung metastasis mouse model. Both oral and intraperitoneal administration of G.A (50 mg/kg) inhibited lung metastasis of CT26 cells. Various concentrations of G.A were incubated with CRC cell lines and their viability was determined using a cell counting kit-8 assay. G.A significantly decreased the viability of various CRC cell lines, whereas it did not change the proliferation of normal colon cells. G.A induced G0/G1 phase arrest and apoptosis of CT26 and HT29 cells by regulating cyclin D1/cyclin-dependent kinase 4 (CDK4) expression and apoptotic proteins such as caspases and B-cell lymphoma-2 (Bcl-2) family proteins, respectively. G.A-induced apoptosis was mediated by AMPK/p38 activation in CRC cells. A non-cytotoxic concentration of G.A inhibited epithelial–mesenchymal transition of CRC cells by modulating E-cadherin and N-cadherin expression levels. Moreover, the migration and invasion of CRC cells were reduced by G.A treatment. Especially, G.A decreased matrix metalloproteinase (MMP)-2 and MMP-9 expressions and activities. G.A ameliorated lung metastasis of CRC cells by decreasing cell survival and metastatic abilities of CRC cells. Thus, G.A might be a potential novel therapeutic agent for metastatic CRC.

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Evaluation of Cytotoxic Activity ofSchisandra chinensisLignans

Cited by 33 publications

References 22 publications

Cytotoxic and potential anticancer constituents from the stems ofSchisandra pubescens

Cytotoxic and potential anticancer constituents from the stems ofSchisandra pubescens

Panax ginsengRhodiola roseaandSchisandra chinensis

Gomisin A Suppresses Colorectal Lung Metastasis by Inducing AMPK/p38-Mediated Apoptosis and Decreasing Metastatic Abilities of Colorectal Cancer Cells

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