Evaluation of cytokines (MIG, IFN-γ, TNF-α, IL-4, IL-5, and IL-10) during the different evolutive phases of chagasic esophagopathy

Crema, Eduardo; Monteiro, Isabela de Oliveira; Gomes, Marília Gabriela Zanier; Silva, Alex Augusto; Júnior, Virmondes Rodrigues

doi:10.1016/j.clim.2005.12.011

Cited by 16 publications

(14 citation statements)

References 20 publications

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“…An association between brain atrophy and systemic inflammation (high IL-6 and TNF-alfa levels) has been reported [7]. Both IL-6 and TNF-alfa production are associated with chronic Chagas disease [4,5]. Thus, we hypothesize that chronic inflammation in Chagas disease may underlie the mechanism for a progressive form of brain atrophy [8].…”

Section: Discussionmentioning

confidence: 85%

Chagas disease is independently associated with brain atrophy

et al. 2009

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Chagas disease (CD) remains a major cause of cardiomyopathy and stroke in developing countries. Brain involvement in CD has been attributed to left ventricular dysfunction, resulting in chronic brain ischemia due to hypoperfusion and/or embolic infarcts. However, cognitive impairment in CD may occur independently of cardiac disease. Therefore, we aimed to investigate head computed tomography (CT) findings in patients with Chagas disease cardiomyopathy (CDC) in comparison with other cardiomyopathies (OC). We studied 73 patients with CDC (n = 41) or OC (n = 32) matched for age and gender. These patients underwent head CT, rated by an investigator blinded to all clinical information. Head CT was rated for the presence of lacunar or territorial infarcts, as well as for measuring the total volumes of the brain, cerebellum and ventricles. Total brain volume was smaller in CDC as compared to OC patients (1,135 +/- 150 vs. 1,332 +/- 198 cm(3), P < 0.001). Cerebellar and ventricular volumes did not differ between the groups. The prevalence of brain infarcts did not differ significantly between the groups. Chagas disease was the only independent predictor of brain atrophy in the multivariable analysis (OR = 1.38; 95% CI = 1.06-1.79, P = 0.017). Chagas disease is associated with brain atrophy independent of structural cardiac disease related to cardiomyopathy. Brain atrophy, rather than multiple infarcts, may represent the main anatomical substrate of cognitive impairment in Chagas disease.

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Section: Discussionmentioning

confidence: 85%

Chagas disease is independently associated with brain atrophy

et al. 2009

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“…It has been hypothesized that alterations in the immune response are more likely to be involved in the pathogenesis of Chagas disease and that the chronic forms result from multifactorial immunological mechanisms. An impaired cytokine network has been pointed out as one of the determining factors in disease morbidity [5], [8], [15].…”

Section: Discussionmentioning

confidence: 99%

Plasma Cytokine Expression Is Associated with Cardiac Morbidity in Chagas Disease

et al. 2014

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The expression of immune response appears to be associated with morbidity in Chagas disease. However, the studies in this field have usually employed small samples of patients and statistical analyses that do not consider the wide dispersion of cytokine production observed in these patients. The aim of this study was to evaluate the plasma cytokine levels in well-defined clinical polar groups of chagasic patients divided into categories that better reflect the wide cytokine profile and its relationship with morbidity. Patients infected with Trypanosoma cruzi (T. cruzi) were grouped as indeterminate (IND) and cardiac (CARD) forms ranging from 23 to 69 years of age (mean of 45.6±11.25). The IND group included 82 individuals, ranging from 24 to 66 years of age (mean of 39.6±10.3). The CARD group included 94 patients ranging from 23 to 69 years of age (mean of 48±12.52) presenting dilated cardiomyopathy. None of the patients have undergone chemotherapeutic treatment, nor had been previously treated for T. cruzi infection. Healthy non-chagasic individuals, ranging from 29 to 55 years of age (mean of 42.6±8.8) were included as a control group (NI). IND patients have a higher intensity of interleukin 10 (IL-10) expression when compared with individuals in the other groups. By contrast, inflammatory cytokine expression, such as interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and interleukin 1 beta (IL-1β), proved to be the highest in the CARD group. Correlation analysis showed that higher IL-10 expression was associated with better cardiac function, as determined by left ventricular ejection fraction and left ventricular diastolic diameter values. Altogether, these findings reinforce the concept that a fine balance between regulatory and inflammatory cytokines represents a key element in the establishment of distinct forms of chronic Chagas disease.

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“…In humans and in experimental models, T. cruzi infection has been associated with immunosuppression, which may function as a mechanism of parasite escape or, conversely, to prevent tissue damage (de Barros-Mazon et al 2004;Crema et al 2006). In the present study, we observed that the Th-1-type cytokines were significantly decreased in the tongue of patients with Chagas' disease.…”

Section: Discussionmentioning

confidence: 99%

Expression of cytokines and chemokines and microvasculature alterations of the tongue from patients with chronic Chagas’ disease

et al. 2009

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Chagas' disease is caused by the protozoan Trypanosoma cruzi and continues to be a significant public health problem, since 10 million people are still infected in Latin America. The purpose of this study was to analyze the microvasculature alterations as well the expression of cytokines and chemokines in the tongues from patients with chronic Chagas' disease (CC; n = 18), comparatively with a non-chagasic group (NC; n = 22). We observed several vascular alterations in the tongue of CC such as a greater vascular diameter, increased vascular wall area, high density of the blood vessels, and increased thickening of the capillary basement membrane. The expression of cytokines interferon gamma and tumor necrosis factor alpha and chemokine macrophage inflammatory protein 1alpha were significantly down-regulated in the tongue of CC group. These results demonstrated that, in the tongue of chagasic patients, a microvascular abnormality and immunological impairment occurs, probably due to chronic inflammation evoked by T. cruzi antigens.

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Evaluation of cytokines (MIG, IFN-γ, TNF-α, IL-4, IL-5, and IL-10) during the different evolutive phases of chagasic esophagopathy

Cited by 16 publications

References 20 publications

Chagas disease is independently associated with brain atrophy

Chagas disease is independently associated with brain atrophy

Plasma Cytokine Expression Is Associated with Cardiac Morbidity in Chagas Disease

Expression of cytokines and chemokines and microvasculature alterations of the tongue from patients with chronic Chagas’ disease

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