Evaluation of Cyavanaprāśa on health and immunity related parameters in healthy children: A two arm, randomized, open labeled, prospective, multicenter, clinical study

Gupta, Arun Kumar; Kumar, Sunil; Dole, S; Deshpande, Shailesh; Deshpande, Vaishali; Singh, Sudha; Vedula, Sasibhushan

doi:10.4103/asl.asl_8_17

Cited by 23 publications

(15 citation statements)

References 12 publications

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“…Although several types of research have been published on Chyawanprash to report its health benefits against various ailments, the study reports antioxidant ( Anil and Suresh, 2011 ) free radical scavenging ( Bhattacharya et al, 2002 ) antibacterial, antiviral, anti-inflammatory, antiallergic, and antithrombotic effects ( Gupta et al, 2017 ). In a randomized controlled trial, it was found effective for pulmonary tuberculosis as an adjunct to antitubercular drugs.…”

Section: Ayush Recommendations For Management Of Covid-19mentioning

confidence: 99%

Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research

et al. 2021

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The cases of COVID-19 are still increasing day-by-day worldwide, even after a year of its first occurrence in Wuhan city of China. The spreading of SARS-CoV-2 infection is very fast and different from other SARS-CoV infections possibly due to structural differences in S proteins. The patients with severe diseases may die due to acute respiratory distress syndrome (ARDS) caused by systemic inflammatory reactions due to the excessive release of pro-inflammatory cytokines and chemokines by the immune effector cells. In India too, it is spreading very rapidly, although the case fatality rate is below 1.50% (https://www.statista.com), which is markedly less than in other countries, despite the dense population and minimal health infrastructure in rural areas. This may be due to the routine use of many immunomodulator medicinal plants and traditional AYUSH formulations by the Indian people. This communication reviews the AYUSH recommended formulations and their ingredients, routinely used medicinal plants and formulations by Indian population as well as other promising Indian medicinal plants, which can be tested against COVID-19. Special emphasis is placed on Indian medicinal plants reported for antiviral, immunomodulatory and anti-allergic/anti-inflammatory activities and they are categorized for prioritization in research on the basis of earlier reports. The traditional AYUSH medicines currently under clinical trials against COVID-19 are also discussed as well as furtherance of pre-clinical and clinical testing of the potential traditional medicines against COVID-19 and SARS-CoV-2. The results of the clinical studies on AYUSH drugs will guide the policymakers from the AYUSH systems of medicines to maneuver their policies for public health, provide information to the global scientific community and could form a platform for collaborative studies at national and global levels. It is thereby suggested that promising AYUSH formulations and Indian medicinal plants must be investigated on a priority basis to solve the current crisis.

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Section: Ayush Recommendations For Management Of Covid-19mentioning

confidence: 99%

Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research

et al. 2021

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“…In a 6-month-long randomized, open labelled, prospective, multicenter, clinical study in children (5–12 years), CP was shown to lead to significant improvement in immunity, energy levels, physical strength, vigor, and quality of life assessed through KIDSCREEN QOL-27 questionnaires in children [116].…”

Section: Health Benefitsmentioning

confidence: 99%

Chyawanprash: A Traditional Indian Bioactive Health Supplement

et al. 2019

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Chyawanprash (CP) is an Ayurvedic health supplement which is made up of a super-concentrated blend of nutrient-rich herbs and minerals. It is meant to restore drained reserves of life force (ojas) and to preserve strength, stamina, and vitality, while stalling the course of aging. Chyawanprash is formulated by processing around 50 medicinal herbs and their extracts, including the prime ingredient, Amla (Indian gooseberry), which is the world’s richest source of vitamin C. Chyawanprash preparation involves preparing a decoction of herbs, followed by dried extract preparation, subsequent mixture with honey, and addition of aromatic herb powders (namely clove, cardamom, and cinnamon) as standard. The finished product has a fruit jam-like consistency, and a sweet, sour, and spicy flavor. Scientific exploration of CP is warranted to understand its therapeutic efficacy. Scattered information exploring the therapeutic potential of CP is available, and there is a need to assemble it. Thus, an effort was made to compile the scattered information from ancient Ayurvedic texts and treatises, along with ethnobotanical, ethnopharmacological, and scientifically validated literature, that highlight the role of CP in therapeutics. Citations relevant to the topic were screened.

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“…It is well known to have antiinflammatory and immunomodulatory properties and is being studied for COVID-19 [12,13]. Chyavanprash has also being tried in some trials as it boosts host's immunity [14,15] Similarly, Arsenic album which is found to be effective in flu-like illnesses is also one the most studied preparation amongst the homeopathic trials [16].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic clinical trials to combat COVID-19 pandemic in India: analysis from trial registry

Batta

Khirasaria²,

Kapoor

et al. 2020

Journal of Basic and Clinical Physiology and Pharmacology

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ObjectivesWith the emergence of Novel corona virus, hunt for finding a preventive and therapeutic treatment options has already begun at a rapid pace with faster clinical development programs. The present study was carried out to give an insight of therapeutic interventional trials registered under clinical trial registry of India (CTRI) for COVID-19 pandemic.MethodsAll trials registered under CTRI were evaluated using keyword “COVID” from its inception till 9th June 2020. Out of which, therapeutic interventional studies were chosen for further analysis. Following information was collected for each trial: type of therapeutic intervention (preventive/therapeutic), treatment given, no. of centers (single center/multicentric), type of institution (government/private), study design (randomized/single-blinded/double-blinded) and sponsors (Government/private). Microsoft Office Excel 2007 was used for tabulation and analysis.ResultsThe search yielded total of 205 trials, out of which, 127 (62%) trials were interventional trials. Out of these, 71 (56%) were AYUSH interventions, 36 (28.3%) tested drugs, 9 (7%) tested a nondrug intervention, rest were nutraceuticals and vaccines. About 66 (56%) were therapeutic trials. Majority were single-centered trials, i.e. 87 (73.7%). Trials were government funded in 57 (48.3%) studies. Majority were randomized controlled trials, i.e. 67 (56.8%). AYUSH preparations included AYUSH-64, Arsenic Album, SamshamaniVati etc.ConclusionsThe number of therapeutic interventional clinical trials was fair in India. A clear-cut need exists for an increase in both quantity and quality of clinical trials for COVID-19. Drug repurposing approach in all systems of medicine can facilitate prompt clinical decisions at lower costs than de novo drug development.

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Evaluation of Cyavanaprāśa on health and immunity related parameters in healthy children: A two arm, randomized, open labeled, prospective, multicenter, clinical study

Cited by 23 publications

References 12 publications

Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research

Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research

Chyawanprash: A Traditional Indian Bioactive Health Supplement

Therapeutic clinical trials to combat COVID-19 pandemic in India: analysis from trial registry

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