Evaluation of cutaneous drug reactions in patients visiting out patient departments of Indira Gandhi Government Medical College and Hospital (IGGMC and H), Nagpur

Abstract

Objectives:To detect cutaneous drug reactions through spontaneous reporting system in IGGMCand H, Nagpur and analyze them using standard assessment scales.Materials and Methods:An observational, prospective study was performed in patients attending dermatology OPD of IGGMC and H, Nagpur from 1st June 05 to 31st May 09. Patients were examined for cutaneous drug reactions (CDRs) by spontaneous Adverse Drug Reaction reporting system.Results:Among 2693 total ADRs reported, 872 (33.04%) were CDRs. Antimicrobials (55.5%) were the main drugs involved followed by NSAIDs (18.56%) and steroids (12.61%). Maculopapular rash (37.73%) followed by fixed drug eruption (17.2%) and urticaria (14.56%) were the most frequently observed CDRs. The common drugs causing CDRs were cotrimoxazole (20.41%), topical steroids (betamethasone), ibuprofen (7.91%), ampicillin (6.54%), diclofenac (4.7%) and iron dextran (3.44%).Conclusion:It was observed that commonly used drugs like antibiotics and NSAIDs lead to maximum number of CDRs. Hence strict vigilance is required while using them. This study provides a database of ADRs due to common drugs, which will help clinicians in safe use of these drugs.

Dermatological adverse drug reactions in tertiary care hospital: an analysis of causality and severity

“…This finding is less than that of 55.5%, 50.9% and 39.1% as reported by other groups. [18][19][20] It is approximately near (34.10%) to study done by Chatterjee. S, et al, and Ghosh.…”

“…Therefore, the frequency and proportions of dermatological ADRs from Indian System of Reporting cannot be matched (compared) with data from other reporting systems. 18,19,21 In this study, authors found out that, Oral and Injectable Antimicrobials (35%) are the leading cause of the dermatological ADRs. This finding is less than that of 55.5%, 50.9% and 39.1% as reported by other groups.…”

“…6 Very few studies related with dermatological manifestations of Adverse Drug Reactions have been carried out in India until date, hence, we decided to carry out this study in population from central India. [15][16][17][18][19][20][21][22] Different studies have reported different incidence rates, which vary from 2% to 30%. [11][12][13] In this study, authors did not try to find out incidence, as the data regarding total number of ADRs at our Hospital was not available.…”

Adverse drug reactions to ibuprofen: a case report

“…1,7,12 This patient developed allergic bronchial asthma & angioedema after taking one tablet of ibuprofen. He presented with swelling over lip, orbital area, throat and severe breathing difficulty.…”

Rabeprazole induced Fixed Drug Eruption: A rare case report

“…Most common among them is cutaneous adverse drug reactions [1] with fixed drug eruption being the most common cutaneous drug reaction among the Indian population [2]. The drugs most commonly implicated in fixed drug eruption are analgesics and antibiotics [2].…”