Evaluation of Curcumin's effect on inflammation in hemodialysis patients

Samadian, Fariba; Dalili, Nooshin; Gholi, Fatemeh Poor reza; Fattah, Mahtab; Malih, Narges; Nafar, Mohsen; Firoozan, Ahmad; Ahmadpoor, Pedram; Samavat, Shiva; Ziaie, Shadi

doi:10.1016/j.clnesp.2017.09.006

Cited by 39 publications

(36 citation statements)

References 15 publications

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“…The results of our randomized trial suggest that, in hemodialysis patients, a 12‐week period of supplementation with nanocurcumin is associated with substantial and statistically significant reductions in both the serum level and gene expression of two cytokines that have been linked to inflammation: TNF‐α and IL‐6. Our results support and extend the findings of Samadian et al showing that turmeric ingestion can significantly reduce IL‐6 and TNF‐α levels in the hemodialysis patients 16 …”

Section: Discussionsupporting

confidence: 92%

“…In the study or curcumin administration to dialysis patients conducted by Samadian et al, the levels of IL‐6 and TNF‐α were significantly decreased at the end of the study period in the group that received curcumin, but there was no difference between the curcumin and placebo groups in end‐of‐study cytokine levels 16 . In the present study, we did find differences, not only in the change in cytokine levels from baseline to 12 weeks, but in end‐of‐study serum cytokine levels.…”

Section: Discussionmentioning

confidence: 96%

“…Our results support and extend the findings of Samadian et al showing that turmeric ingestion can significantly reduce IL-6 and TNF-α levels in the hemodialysis patients. 16 In the present study, a nanomicelle formulation of curcumin was used, which has been shown to increase the absorption of curcumin up to 60 times compared with regular dosage forms. 14 Curcumin is known to have a low bioavailability due to its limited water solubility.…”

Section: Discussionmentioning

confidence: 99%

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The effects of nanocurcumin supplementation on inflammation in hemodialysis patients: A randomized controlled trial

Vafadar-Afshar

Rasmi

Yaghmaei

et al. 2021

Hemodialysis International

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Introduction: Serum levels of several pro-inflammatory cytokines are higher in hemodialysis patients compared to healthy people. Curcumin has been shown to be able to decrease cytokines levels in nonuremic subjects. Our goal was to evaluate the effect of nanocurcumin administration on cytokines levels in hemodialysis patients. Methods:The study was performed over a 3 months period on 54 hemodialysis patients who had been randomized to receive either nanocurcumin or placebo. Serum levels and gene expressions of tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) were evaluated using enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (RT-PCR).Findings: Serum levels of IL-6 and TNF-α were similar in the two groups at baseline but were lower after 12 weeks of treatment with nanocurcumin compared to placebo (P = 0.024 for IL-6 and 0.02 for TNF). In the group given nanocurcumin, serum levels of both cytokines decreased substantially (P < 0.001 for each), whereas they were unchanged in the group given placebo. Gene expression for each cytokine in peripheral blood mononuclear cells (PBMCs) was reduced at 12 weeks vs. baseline in the group given nanocurcumin, and changes in gene expression correlated with changes in serum level for each of the two cytokines. Discussion:The results indicate that nanocurcumin supplementation reduces both serum levels and gene expression of IL-6 and TNF-α in hemodialysis patients. The feasibility and potential clinical benefits of nanocurcumin treatment to reduce inflammation in hemodialysis patients warrant further study.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effects of nanocurcumin supplementation on inflammation in hemodialysis patients: A randomized controlled trial

Vafadar-Afshar

Rasmi

Yaghmaei

et al. 2021

Hemodialysis International

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“…Besides it, the protective effect of turmeric on the intestinal epithelium may be promising for patients with inflammatory bowel disease [78]. Also, it has been shown that turmeric significantly lowers the level of high-sensitivity C-reactive protein (as an acute-phase protein) in a number of clinical trials [79,80].…”

Section: Antioxidant and Anti-inflammatory Activitymentioning

confidence: 99%

Biochemistry, Safety, Pharmacological Activities, and Clinical Applications of Turmeric: A Mechanistic Review

Ahmad

Hussain

Sultan³

et al. 2020

Evidence-Based Complementary and Alternative Medicine

102

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Turmeric (Curcuma longa L.) is a popular natural drug, traditionally used for the treatment of a wide range of diseases. Its root, as its most popular part used for medicinal purposes, contains different types of phytochemicals and minerals. This review summarizes what is currently known on biochemistry, safety, pharmacological activities (mechanistically), and clinical applications of turmeric. In short, curcumin is considered as the fundamental constituent in ground turmeric rhizome. Turmeric possesses several biological activities including anti-inflammatory, antioxidant, anticancer, antimutagenic, antimicrobial, antiobesity, hypolipidemic, cardioprotective, and neuroprotective effects. These reported pharmacologic activities make turmeric an important option for further clinical research. Also, there is a discussion on its safety and toxicity.

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“…48 This same mechanism (a dissociation of the raptor protein from mTOR) is also responsible for rapamycin's inhibitory effects. 49 While numerous clinical trials have been conducted on curcumin supplementation, demonstrating anti-inflammatory or anticancer effects, [50][51][52][53][54][55][56] no human trials investigating a direct effect of curcumin on mTOR have been performed.…”

Section: Curcuminmentioning

confidence: 99%

Botanical Medicine and Phytochemicals in Healthy Aging and Longevity—Part 1

Lucius

2020

Alternative and Complementary Therapies

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Evaluation of Curcumin's effect on inflammation in hemodialysis patients

Cited by 39 publications

References 15 publications

The effects of nanocurcumin supplementation on inflammation in hemodialysis patients: A randomized controlled trial

The effects of nanocurcumin supplementation on inflammation in hemodialysis patients: A randomized controlled trial

Biochemistry, Safety, Pharmacological Activities, and Clinical Applications of Turmeric: A Mechanistic Review

Botanical Medicine and Phytochemicals in Healthy Aging and Longevity—Part 1

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