Evaluation of Cupric Sulphate as an Acaricide Against<i>Varroa Jacobsoni O</i>.

Guiraud, Georges; Nectoux, M.; Andre, J.-E.; Bounias, M.; Popeskovic, D.

doi:10.1080/00218839.1989.11101185

Journal of Apicultural Research

1989

DOI: 10.1080/00218839.1989.11101185

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Evaluation of Cupric Sulphate as an Acaricide AgainstVarroa Jacobsoni O.

Georges Guiraud

M. Nectoux

J.-E. Andre³

et al.

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Cited by 3 publications

(2 citation statements)

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“…Cupric salts (e.g. cupric gluconate, cupric aspartate, cupric isoleucinate) are a potential treatment for Varroa mite, a parasite of honey bees . Although it is toxic to bees at high doses, low doses of cupric gluconate in pollen diets resulted in a significant increase ( P < 0.001) in the lifespan of adult worker bees .…”

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“…cupric gluconate, cupric aspartate, cupric isoleucinate) are a potential treatment for Varroa mite, a parasite of honey bees. 29,30 Although it is toxic to bees at high doses, low doses of cupric gluconate in pollen diets resulted in a significant increase (P < 0.001) in the lifespan of adult worker bees. 31 In laboratory experiments with the bumblebee Bombus impatiens Cresson, topical applications of a formulation of the biopesticide Bacillus subtilis (a gram-positive bacterium that has fungicidal activity) at concentrations less than the recommended field rate resulted in significantly increased progeny production.…”

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Can poisons stimulate bees? Appreciating the potential of hormesis in bee-pesticide research

Cutler

Rix

2015

Pest. Manag. Sci.

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Hormesis, a biphasic dose response whereby exposure to low doses of a stressor can stimulate biological processes, has been reported in many organisms, including pest insects when they are exposed to low doses of a pesticide. However, awareness of the hormesis phenomenon seems to be limited among bee researchers, in spite of the increased emphasis of late on pollinator toxicology and risk assessment. In this commentary, we show that there are several examples in the literature of substances that are toxic to bees at high doses but stimulatory at low doses. Appreciation of the hormetic dose response by bee researchers will improve our fundamental understanding of how bees respond to low doses of chemical stressors, and may be useful in pollinator risk assessment.

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confidence: 99%

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confidence: 99%

Can poisons stimulate bees? Appreciating the potential of hormesis in bee-pesticide research

Cutler

Rix

2015

Pest. Manag. Sci.

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Toxicology of cupric salts on honeybees IV — gluconate and sulfate action on hemolymph trehalose activity in vivo and in vitro

Nectoux

Bounias

Popeskovic

1995

J. Biochem. Toxicol.

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A biphasic increase of hemolymph glucose levels was observed following injection to bees of cupric gluconate or sulfate, both potent agents for the control of Varroa jacobsoni, a parasitic mite of hives. The simultaneous injection to bees of 0.3 microM BAYg5421 (an inhibitor of alpha-glucosidases) quenched the response, suggesting a direct effect of 2 nmol/bee cupric ions on trehaloses' activity. One nanomol of injected cupric gluconate increased the trehalose (Tre) activity by 233% in crude hemolymph extracts at 1 mM trehalose concentration, and exhibited biphasic dose-related effects with a maximum 15% increase at 0.5 mM cupric ion and a stabilized 20% inhibition from 4 mM, regardless of the anionic moiety. Upon partial purification of the enzyme complex, two fractions (FI = 75% and FII = 25% of total activity) were isolated that exhibited, respectively, less and more marked positive cooperatively than crude extract. Form I showed almost no susceptibility to either cupric derivatives, which indicated form II as the most likely target, with 68% and 72% increases with 0.25 mM cupric sulfate and 0.5 mM cupric gluconate, in presence of 16 mM trehalose.

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Synergistic and molecular interactions between the formamidine amitraz and copper(II) sulfate, used against the mite Varroa jacobsoni O., a parasite of the honeybee Apis mellifera L.

Bounias

Andre²,

Kruk

1993

Biometals

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Toxicological field assays have shown that the shock-treatment efficacy of the formamidine pesticide amitraz, used against the parasitic mite Varroajacobsoni, is synergistically improved by the administration of copper(II) sulfate through feeding of the honeybees. Amitraz is autoxidized and this process is accompanied by chemiluminescence. The emission is enhanced in the presence of low concentrations of H202. A dose-related inhibition of the chemiluminescence by CuSO4 was observed; consistent with the formation of copper-amitraz complexes evidenced in vitro. The results suggest the possibility that a protection of amitraz by cupric ions might be at the origin of the enhancement of its toxicity and thus makes a contribution to the observed synergy.

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Evaluation of Cupric Sulphate as an Acaricide AgainstVarroa Jacobsoni O.

Cited by 3 publications

References 11 publications

Can poisons stimulate bees? Appreciating the potential of hormesis in bee-pesticide research

Can poisons stimulate bees? Appreciating the potential of hormesis in bee-pesticide research

Toxicology of cupric salts on honeybees IV — gluconate and sulfate action on hemolymph trehalose activity in vivo and in vitro

Synergistic and molecular interactions between the formamidine amitraz and copper(II) sulfate, used against the mite Varroa jacobsoni O., a parasite of the honeybee Apis mellifera L.

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